دورية أكاديمية
MRI detection of suspected nasopharyngeal carcinoma: a systematic review and meta-analysis.
| العنوان: | MRI detection of suspected nasopharyngeal carcinoma: a systematic review and meta-analysis. |
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| المؤلفون: | Gorolay VV; Department of Radiology, Royal Price Alfred Hospital, University of Sydney, Sydney, NSW, Australia., Niles NN; Department of Ear, Nose and Throat Surgery, Concord Hospital, Concord, NSW, Australia., Huo YR; Department of Radiology, Hospital Road, Concord Repatriation and General Hospital, University of Sydney, Concord, NSW, 2139, Australia., Ahmadi N; Department of Ear, Nose and Throat Surgery, Royal Prince Alfred Hospital, University of New South Wales, Sydney, NSW, Australia., Hanneman K; Department of Medical Imaging, Peter Munk Cardiac Center, University Health Network, University of Toronto, Toronto, ON, Canada., Thompson E; Department of Radiology, Royal Price Alfred Hospital, University of Sydney, Sydney, NSW, Australia., Chan MV; Department of Radiology, Hospital Road, Concord Repatriation and General Hospital, University of Sydney, Concord, NSW, 2139, Australia. michaelvchan@gmail.com. |
| المصدر: | Neuroradiology [Neuroradiology] 2022 Aug; Vol. 64 (8), pp. 1471-1481. Date of Electronic Publication: 2022 Apr 30. |
| نوع المنشور: | Journal Article; Meta-Analysis; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 1302751 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1920 (Electronic) Linking ISSN: 00283940 NLM ISO Abbreviation: Neuroradiology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging*/methods , Nasopharyngeal Neoplasms*/diagnostic imaging, Case-Control Studies ; Humans ; Nasopharyngeal Carcinoma/diagnostic imaging ; Retrospective Studies ; Sensitivity and Specificity |
| مستخلص: | Purpose: Endoscopic biopsy is recommended for diagnosis of nasopharyngeal carcinoma (NPC). A proportion of lesions are hidden from endoscopic view but detected with magnetic resonance imaging (MRI). This systematic review and meta-analysis investigated the diagnostic performance of MRI for detection of NPC. Methods: An electronic search of twelve databases and registries was performed. Studies were included if they compared the diagnostic accuracy of MRI to a reference standard (histopathology) in patients suspected of having NPC. The primary outcome was accuracy for detection of NPC. Random-effects models were used to pool outcomes for sensitivity, specificity, and positive and negative likelihood ratio (LR). Bias and applicability were assessed using the modified QUADAS-2 tool. Results: Nine studies were included involving 1736 patients of whom 337 were diagnosed with NPC. MRI demonstrated a pooled sensitivity of 98.1% (95% CI 95.2-99.3%), specificity of 91.7% (95% CI 88.3-94.2%), negative LR of 0.02 (95% CI 0.01-0.05), and positive LR of 11.9 (95% CI 8.35-16.81) for detection of NPC. Most studies were performed in regions where NPC is endemic, and there was a risk of selection bias due to inclusion of retrospective studies and one case-control study. There was limited reporting of study randomization strategy. Conclusion: This study demonstrates that MRI has a high pooled sensitivity, specificity, and negative predictive value for detection of NPC. MRI may be useful for lesion detection prior to endoscopic biopsy and aid the decision to avoid biopsy in patients with a low post-test probability of disease. (© 2022. The Author(s).) |
| التعليقات: | Comment in: Neuroradiology. 2023 Jan;65(1):1-2. (PMID: 36350360) Comment in: Neuroradiology. 2023 Jan;65(1):3. (PMID: 36371510) |
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| فهرسة مساهمة: | Keywords: Biopsy; MRI; Nasopharyngeal carcinoma |
| تواريخ الأحداث: | Date Created: 20220502 Date Completed: 20220712 Latest Revision: 20230803 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9271105 |
| DOI: | 10.1007/s00234-022-02941-w |
| PMID: | 35499636 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-1920 |
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| DOI: | 10.1007/s00234-022-02941-w |