تقرير
A case of acute endothelial corneal transplant rejection following immunization with ChAdOx1 nCoV-19 coronavirus vaccine.
| العنوان: | A case of acute endothelial corneal transplant rejection following immunization with ChAdOx1 nCoV-19 coronavirus vaccine. |
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| المؤلفون: | Nahata H; Department of Cornea and External Diseases of the Eye, Narayana Nethralaya, Bengaluru, Karnataka, India., Nagaraja H; Department of Cornea and External Diseases of the Eye, Narayana Nethralaya, Bengaluru, Karnataka, India., Shetty R; Department of Cornea and External Diseases of the Eye, Narayana Nethralaya, Bengaluru, Karnataka, India. |
| المصدر: | Indian journal of ophthalmology [Indian J Ophthalmol] 2022 May; Vol. 70 (5), pp. 1817-1818. |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medknow Publications Country of Publication: India NLM ID: 0405376 Publication Model: Print Cited Medium: Internet ISSN: 1998-3689 (Electronic) Linking ISSN: 03014738 NLM ISO Abbreviation: Indian J Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Mumbai : Medknow Publications Original Publication: Bombay : All-India Ophthalmological Society |
| مواضيع طبية MeSH: | COVID-19* , Corneal Diseases*/surgery , Corneal Transplantation*/adverse effects, Adult ; COVID-19 Vaccines/adverse effects ; ChAdOx1 nCoV-19 ; Endothelium ; Female ; Graft Rejection/diagnosis ; Humans ; Immunization ; Postoperative Complications ; Steroids ; Vaccination ; Visual Acuity |
| مستخلص: | A 28-year-old female who underwent an uneventful femtosecond laser enabled keratoplasty (FLEK) in her left eye presented with pain, redness, and blurring of vision in the operated eye two weeks after getting immunized with COVID-19 vector vaccine (ChAdOx1 nCoV19 Vaccine Recombinant COVISHIELD, AstraZeneca). Slit-lamp examination showed donor stromal edema with Descemet's membrane folds and Khodadoust line (KP's on endothelium) with anterior chamber cells and flare. The patient was diagnosed with acute corneal graft rejection and advised hourly topical steroids with cycloplegics and oral steroids. The patient responded to treatment and there was progressive reversal of graft rejection with the patient achieving best spectacle-corrected visual acuity (BSCVA) of 20/30 after five weeks of treatment. Our case highlights possible immune corneal graft rejection after COVID19 vaccination and the need to step up topical steroids before vaccination. Competing Interests: None |
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| فهرسة مساهمة: | Keywords: COVID-19; Khodadoust line; graft rejection; keratoplasty; vaccination |
| المشرفين على المادة: | 0 (COVID-19 Vaccines) 0 (Steroids) B5S3K2V0G8 (ChAdOx1 nCoV-19) |
| تواريخ الأحداث: | Date Created: 20220503 Date Completed: 20220504 Latest Revision: 20220731 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9332947 |
| DOI: | 10.4103/ijo.IJO_66_22 |
| PMID: | 35502082 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1998-3689 |
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| DOI: | 10.4103/ijo.IJO_66_22 |