دورية أكاديمية
أعرض في EDS

Development of an Inflammatory Bowel Disease-Specific Medication Adherence Instrument and Reasons for Non-adherence.

التفاصيل البيبلوغرافية
العنوان: Development of an Inflammatory Bowel Disease-Specific Medication Adherence Instrument and Reasons for Non-adherence.
المؤلفون: Brenner EJ; Department of Pediatric Gastroenterology, University of North Carolina, 333 S. Columbia Street, 247 MacNider Hall, CB# 7229, Chapel Hill, NC, 27599, USA. Erica.Brenner@unchealth.unc.edu., Long MD; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Kappelman MD; Department of Pediatric Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Zhang X; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Sandler RS; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Barnes EL; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA.
المصدر: Digestive diseases and sciences [Dig Dis Sci] 2023 Jan; Vol. 68 (1), pp. 58-64. Date of Electronic Publication: 2022 May 03.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : New York, NY : Springer Science + Business Media
Original Publication: New York, Plenum Pub. Corp.
مواضيع طبية MeSH: Inflammatory Bowel Diseases*/drug therapy, Adult ; Humans ; Female ; Middle Aged ; Male ; Medication Adherence ; Smoking ; Emotions
مستخلص: Background: Medication adherence impacts disease control in inflammatory bowel disease (IBD). Existing adherence measures such as the Morisky Medication Adherence Scale 8 © are often costly, non-medication-specific, and time-consuming.
Aims: We aimed to develop a non-proprietary, IBD-specific medication adherence instrument and to assess reasons for suboptimal medication adherence.
Methods: We developed the IBD Medication Adherence Tool to assess frequency of adherence and indications for missed or delayed medication doses. We co-administered the IBD Medication Adherence Tool and the Morisky Medication Adherence Scale 8 © (licensed for use) to participants enrolled in an internet-based cohort of adults with IBD and taking least one daily, oral IBD medication. We used Spearman's correlation to evaluate associations between the IBD Medication Adherence Tool and Morisky Medication Adherence Scale 8 © . We then categorized patients as sub-optimally adherent (IBD Medication Adherence Tool score 1-4) and highly adherent (score 5) and evaluated factors associated with and reasons for suboptimal adherence using multivariable analysis.
Results: We evaluated 514 patients (73% female, mean age 49), of whom 21.4% had suboptimal adherence. IBD Medication Adherence Tool scores were moderately correlated with Morisky Medication Adherence Scale 8 © (r = 0.56, p < 0.001). The most commonly reported reasons for suboptimal adherence were forgetting, feeling well, and cost. Younger age and current smoking were associated with suboptimal adherence.
Conclusions: We developed a non-proprietary, IBD-specific tool to assess adherence to IBD medications, validated in a cohort of patients with IBD on daily, oral medications. Common reasons for suboptimal IBD medication adherence include forgetting, feeling well, and cost.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
References: Chan W, Chen A, Tiao D, Selinger C, Leong R. Medication adherence in inflammatory bowel disease. Intest Res. 2017;15:434–445. (PMID: 10.5217/ir.2017.15.4.434)
Kane SV, Robinson A. Review article: understanding adherence to medication in ulcerative colitis—innovative thinking and evolving concepts. Aliment Pharmacol Ther. 2010;32:1051–1058. (PMID: 10.1111/j.1365-2036.2010.04445.x)
Severs M, Zuithoff PN, Mangen MJ et al. Assessing self-reported medication adherence in inflammatory bowel disease: a comparison of tools. Inflamm Bowel Dis. 2016;22:2158–2164. (PMID: 10.1097/MIB.0000000000000853)
Trindade AJ, Ehrlich A, Kornbluth A, Ullman TA. Are your patients taking their medicine? Validation of a new adherence scale in patients with inflammatory bowel disease and comparison with physician perception of adherence. Inflamm Bowel Dis. 2011;17:599–604. (PMID: 10.1002/ibd.21310)
Brady JE, Stott-Miller M, Mu G, Perera S. Treatment patterns and sequencing in patients with inflammatory bowel disease. Clin Ther. 2018;40:1509-1521.e1505. (PMID: 10.1016/j.clinthera.2018.07.013)
Abraham BP, Ahmed T, Ali T. Inflammatory bowel disease: pathophysiology and current therapeutic approaches. In: Greenwood-Van Meerveld B, ed. Berlin: Springer; 2017; 115–146. (PMID: 10.1007/164_2016_122)
Na S-Y, Moon W. Perspectives on current and novel treatments for inflammatory bowel disease. Gut Liver 2019;13:604–616. (PMID: 10.5009/gnl19019)
Goh SSL, Lai PSM, Liew S-M, Tan KM, Chung WW, Chua SS. Development of a PATIENT-medication adherence instrument (P-MAI) and a HEALTHCARE PROFESSIONAL-medication adherence instrument (H-MAI) using the nominal group technique. PLoS ONE 2020;15:e0242051–e0242051. (PMID: 10.1371/journal.pone.0242051)
Long MD, Kappelman MD, Martin CF et al. Development of an internet-based cohort of patients with inflammatory bowel diseases (CCFA Partners): methodology and initial results. Inflamm Bowel Dis. 2012;18:2099–2106. (PMID: 10.1002/ibd.22895)
Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008;10:348–354. (PMID: 10.1111/j.1751-7176.2008.07572.x)
Krousel-Wood M, Islam T, Webber LS, Re RN, Morisky DE, Muntner P. New medication adherence scale versus pharmacy fill rates in seniors with hypertension. Am J Manag Care. 2009;15:59–66.
Kane S, Becker B, Harmsen WS, Kurian A, Morisky DE, Zinsmeister AR. Use of a screening tool to determine nonadherent behavior in inflammatory bowel disease. Am J Gastroenterol. 2012;107:154–160. (PMID: 10.1038/ajg.2011.317)
Trindade AJ, Tinsley A, Kornbluth A, Ullman TA. The MMAS-8, a screening tool for determining nonadherent behavior, should not be dismissed in IBD. Am J Gastroenterol. 2012;107:951–952; author reply 952.
Scale MMA. Student Pricing. http://www.moriskyscale.com/student-pricing.html . Accessed May 4th, 2021.
Services POoR. Consider Alternatives to the Morisky Medication Adherence Scale (MMAS-4 and MMAS-8). https://researchservices.upenn.edu/2020/02/24/consider-alternatives-to-the-morisky-medication-adherence-scale-mmas-4-and-mmas-8/ . Accessed May 4th, 2021.
Watch R. If you use this research tool without permission, you'll hear about it. https://retractionwatch.com/2017/01/26/use-research-tool-without-permission-youll-hear/ . Accessed May 4th, 2021.
Yu H, MacIsaac D, Wong JJ et al. Market share and costs of biologic therapies for inflammatory bowel disease in the USA. Aliment Pharmacol Ther. 2018;47:364–370. (PMID: 10.1111/apt.14430)
Domènech E, Mañosa M, Navarro M et al. Long-term methotrexate for Crohn’s disease: safety and efficacy in clinical practice. J Clin Gastroenterol. 2008;42:395–399. (PMID: 10.1097/MCG.0b013e31802e6875)
Ghadir MR, Bagheri M, Vahedi H et al. Nonadherence to medication in inflammatory bowel disease: rate and reasons. Middle East J Dig Dis. 2016;8:116–121. (PMID: 10.15171/mejdd.2016.16)
Lasa J, Correa G, Fuxman C et al. Treatment adherence in inflammatory bowel disease patients from Argentina: a multicenter study. Gastroenterol Res Pract. 2020;2020:4060648. (PMID: 10.1155/2020/4060648)
Irwin DE, Stucky BD, Thissen D et al. Sampling plan and patient characteristics of the PROMIS pediatrics large-scale survey. Qual Life Res. 2010;19:585–594. (PMID: 10.1007/s11136-010-9618-4)
معلومات مُعتمدة: T32 DK007634 United States NH NIH HHS; K23 DK127157 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Compliance; Crohn’s disease; Inflammatory bowel disease; Medication adherence; Ulcerative colitis
SCR Disease Name: Inflammatory Bowel Disease 4
تواريخ الأحداث: Date Created: 20220503 Date Completed: 20230131 Latest Revision: 20230313
رمز التحديث: 20230313
DOI: 10.1007/s10620-022-07517-5
PMID: 35503483
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-2568
DOI:10.1007/s10620-022-07517-5