دورية أكاديمية
Development of an Inflammatory Bowel Disease-Specific Medication Adherence Instrument and Reasons for Non-adherence.
العنوان: | Development of an Inflammatory Bowel Disease-Specific Medication Adherence Instrument and Reasons for Non-adherence. |
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المؤلفون: | Brenner EJ; Department of Pediatric Gastroenterology, University of North Carolina, 333 S. Columbia Street, 247 MacNider Hall, CB# 7229, Chapel Hill, NC, 27599, USA. Erica.Brenner@unchealth.unc.edu., Long MD; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Kappelman MD; Department of Pediatric Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Zhang X; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Sandler RS; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA., Barnes EL; Department of Gastroenterology, University of North Carolina, 130 Mason Farm Rd, Bioinformatics Building, Suite 4143, Chapel Hill, NC, 27514, USA. |
المصدر: | Digestive diseases and sciences [Dig Dis Sci] 2023 Jan; Vol. 68 (1), pp. 58-64. Date of Electronic Publication: 2022 May 03. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 7902782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2568 (Electronic) Linking ISSN: 01632116 NLM ISO Abbreviation: Dig Dis Sci Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Science + Business Media Original Publication: New York, Plenum Pub. Corp. |
مواضيع طبية MeSH: | Inflammatory Bowel Diseases*/drug therapy, Adult ; Humans ; Female ; Middle Aged ; Male ; Medication Adherence ; Smoking ; Emotions |
مستخلص: | Background: Medication adherence impacts disease control in inflammatory bowel disease (IBD). Existing adherence measures such as the Morisky Medication Adherence Scale 8 © are often costly, non-medication-specific, and time-consuming. Aims: We aimed to develop a non-proprietary, IBD-specific medication adherence instrument and to assess reasons for suboptimal medication adherence. Methods: We developed the IBD Medication Adherence Tool to assess frequency of adherence and indications for missed or delayed medication doses. We co-administered the IBD Medication Adherence Tool and the Morisky Medication Adherence Scale 8 © (licensed for use) to participants enrolled in an internet-based cohort of adults with IBD and taking least one daily, oral IBD medication. We used Spearman's correlation to evaluate associations between the IBD Medication Adherence Tool and Morisky Medication Adherence Scale 8 © . We then categorized patients as sub-optimally adherent (IBD Medication Adherence Tool score 1-4) and highly adherent (score 5) and evaluated factors associated with and reasons for suboptimal adherence using multivariable analysis. Results: We evaluated 514 patients (73% female, mean age 49), of whom 21.4% had suboptimal adherence. IBD Medication Adherence Tool scores were moderately correlated with Morisky Medication Adherence Scale 8 © (r = 0.56, p < 0.001). The most commonly reported reasons for suboptimal adherence were forgetting, feeling well, and cost. Younger age and current smoking were associated with suboptimal adherence. Conclusions: We developed a non-proprietary, IBD-specific tool to assess adherence to IBD medications, validated in a cohort of patients with IBD on daily, oral medications. Common reasons for suboptimal IBD medication adherence include forgetting, feeling well, and cost. (© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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معلومات مُعتمدة: | T32 DK007634 United States NH NIH HHS; K23 DK127157 United States DK NIDDK NIH HHS |
فهرسة مساهمة: | Keywords: Compliance; Crohn’s disease; Inflammatory bowel disease; Medication adherence; Ulcerative colitis |
SCR Disease Name: | Inflammatory Bowel Disease 4 |
تواريخ الأحداث: | Date Created: 20220503 Date Completed: 20230131 Latest Revision: 20230313 |
رمز التحديث: | 20230313 |
DOI: | 10.1007/s10620-022-07517-5 |
PMID: | 35503483 |
قاعدة البيانات: | MEDLINE |
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