دورية أكاديمية
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Isolation and characterization of novel acetylcholinesterase inhibitors from Ficus benghalensis L. leaves.

التفاصيل البيبلوغرافية
العنوان: Isolation and characterization of novel acetylcholinesterase inhibitors from Ficus benghalensis L. leaves.
المؤلفون: Hassan HA; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone New Minia City 61111 Egypt., Allam AE; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University Assiut 71524 Egypt aallam81@yahoo.co.uk., Abu-Baih DH; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Deraya University, Universities Zone New Minia City 61111 Egypt., Mohamed MFA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University 82524 Sohag Egypt., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone New Minia City 61111 Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University Minia 61519 Egypt., Shimizu K; Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Fukuoka 819-0395 Japan., Desoukey SY; Department of Pharmacognosy, Faculty of Pharmacy, Minia University Minia 61519 Egypt., Hayallah AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Universities Zone New Minia City 61111 Egypt.; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University Assiut 71526 Egypt., Elrehany MA; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Deraya University, Universities Zone New Minia City 61111 Egypt., Mohamed KM; Department of Pharmacognosy, Faculty of Pharmacy, Fayoum University Fayoum 63514 Egypt., Kamel MS; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone New Minia City 61111 Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University Minia 61519 Egypt.
المصدر: RSC advances [RSC Adv] 2020 Oct 07; Vol. 10 (60), pp. 36920-36929. Date of Electronic Publication: 2020 Oct 07 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cambridge [England] : Royal Society of Chemistry, [2011]-
مستخلص: Metabolic profiling of the crude methanolic extract of Ficus benghalensis leaves has revealed the presence of different phenolic and nitrogenous compounds including cerebrosides and tetrapyrrole pigments. A phytochemical study of the ethyl acetate fraction resulted in the identification of three known compounds, namely carpachromene (1), alpha amyrine acetate (2), and mucusoside (3) together with one new fatty acid glycoside, named 2- O -α-l-rhamnopyranosyl-hexacosanoate-β-d-glucopyranosyl ester (4). The compounds were identified using 1D, 2D NMR, and HR-ESIMS techniques as well as via comparison to other literature. Studies on the acetylcholinesterase inhibition potential and antioxidant activity were carried out on the total methanolic leaf extract, ethyl acetate fraction, and the isolated compounds. The results revealed the potent acetylcholinesterase inhibition of mucusoside alongside a new compound. Docking studies were also performed to confirm the possible interaction between the isolated compounds and acetylcholinesterase accompanying Alzheimer's disease progress.
Competing Interests: The authors declare there is no conflict of interest.
(This journal is © The Royal Society of Chemistry.)
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تواريخ الأحداث: Date Created: 20220506 Latest Revision: 20231102
رمز التحديث: 20231102
مُعرف محوري في PubMed: PMC9057082
DOI: 10.1039/d0ra06565j
PMID: 35517980
قاعدة البيانات: MEDLINE
الوصف
تدمد:2046-2069
DOI:10.1039/d0ra06565j