دورية أكاديمية
Chimeric Agonist of Galanin Receptor GALR2 Reduces Heart Damage in Rats with Streptozotocin-Induced Diabetes.
| العنوان: | Chimeric Agonist of Galanin Receptor GALR2 Reduces Heart Damage in Rats with Streptozotocin-Induced Diabetes. |
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| المؤلفون: | Studneva IM; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Veselova OM; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Dobrokhotov IV; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Serebryakova LI; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Palkeeva ME; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Molokoedov AS; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Azmuko AA; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Ovchinnikov MV; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Sidorova MV; National Medical Research Center for Cardiology, Moscow, 121552, Russia., Pisarenko OI; National Medical Research Center for Cardiology, Moscow, 121552, Russia. olpi@live.ru. |
| المصدر: | Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2022 Apr; Vol. 87 (4), pp. 346-355. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial, Veterinary |
| اللغة: | English |
| بيانات الدورية: | Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2007->: Moscow : MAIK Nauka/Interperiodica Original Publication: New York, Consultants Bureau [etc.] |
| مواضيع طبية MeSH: | Diabetes Mellitus, Experimental*/chemically induced , Diabetes Mellitus, Experimental*/drug therapy , Heart Injuries*, Adenosine Triphosphate ; Animals ; Lactates ; Peptides/pharmacology ; Rats ; Rats, Wistar ; Receptors, Galanin/agonists ; Receptors, Galanin/metabolism ; Streptozocin |
| مستخلص: | Neuropeptide galanin and its N-terminal fragments reduce the generation of reactive oxygen species and normalize metabolic and antioxidant states of myocardium in experimental cardiomyopathy and ischemia/reperfusion injury. The aim of this study was to elucidate the effect of WTLNSAGYLLGPβAH-OH (peptide G), a pharmacological agonist of the galanin receptor GalR2, on the cardiac injury induced by administration of streptozotocin (STZ) in rats. Peptide G was prepared by solid phase peptide synthesis using the Fmoc strategy and purified by preparative HPLC; its structure was confirmed by 1H-NMR spectroscopy and MALDI-TOF mass spectrometry. Experimental animals were randomly distributed into five groups: C, control; S, STZ-treated; SG10, STZ + peptide G (10 nmol/kg/day); SG50, STZ + peptide G (50 nmol/kg/day); G, peptide G (50 nmol/kg/day). Administration of peptide G prevented hyperglycemia in SG50 rats. By the end of the experiment, the ATP content, total pool of adenine nucleotides, phosphocreatine (PCr) content, and PCr/ATP ratio in the myocardium of animals of the SG50 group were significantly higher than in rats of the S group. In the SG50 and SG10 groups, the content of lactate and lactate/pyruvate ratio in the myocardium were reduced, while the glucose content was increased vs. the S group. Both doses of peptide G reduced the activation of creatine kinase-MB and lactate dehydrogenase, as well as the concentration of thiobarbituric acid reactive products in the blood plasma of STZ-treated rats to the control values. Taken together, these results suggest that peptide G has cardioprotective properties in type 1 diabetes mellitus. Possible mechanisms of peptide G action in the STZ-induced diabetes are discussed. |
| فهرسة مساهمة: | Keywords: cardiomyocyte membranes; galanin; heart; lipid peroxidation; myocardial metabolism; streptozotocin |
| المشرفين على المادة: | 0 (Lactates) 0 (Peptides) 0 (Receptors, Galanin) 5W494URQ81 (Streptozocin) 8L70Q75FXE (Adenosine Triphosphate) |
| تواريخ الأحداث: | Date Created: 20220509 Date Completed: 20220510 Latest Revision: 20220531 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1134/S0006297922040046 |
| PMID: | 35527373 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1608-3040 |
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| DOI: | 10.1134/S0006297922040046 |