دورية أكاديمية
أعرض في EDS

Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite.

التفاصيل البيبلوغرافية
العنوان: Preparation, characterization, in vitro drug release and anti-inflammatory of thymoquinone-loaded chitosan nanocomposite.
المؤلفون: Al-Qubaisi MS; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Al-Abboodi AS; Basic Science Branch, Faculty of Dentistry, University of Al-Qadisiyah, Al-Diwaniyah, Iraq., Alhassan FH; Department of Applied Chemistry and Technology, College of Science and Arts, Alkamel University of Jeddah, Jeddah 21589, Saudi Arabia., Hussein-Al-Ali S; Faculty of Pharmacy, Isra University, Amman 11622, Jordan., Flaifel MH; Department of Physics, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.; Basic & Applied Scientific Research Center, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia., Eid EEM; Department of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Saudi Arabia., Alshwyeh HA; Basic & Applied Scientific Research Center, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia., Hussein MZ; Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Alnasser SM; Department of Pharmacology and Toxicology, Unaizah College of Pharmacy, Qassim University, Saudi Arabia., Saeed MI; Faculty of Medical Laboratory Sciences, National Ribat University, Khartoum 11111, Sudan., Rasedee A; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.; Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia., Ibrahim WN; Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar.
المصدر: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2022 Apr; Vol. 30 (4), pp. 347-358. Date of Electronic Publication: 2022 Feb 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saudi Pharmaceutical Society Country of Publication: Saudi Arabia NLM ID: 9705695 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-0164 (Print) Linking ISSN: 13190164 NLM ISO Abbreviation: Saudi Pharm J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Riyadh : Saudi Pharmaceutical Society
Original Publication: Riyadh, Kingdom of Saudi Arabia : The Society,
مستخلص: In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their anti-inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the production of nitric oxide, prostaglandin E2, tumor necrosis factor-α, interleukin-6, and interleukin-1β. The physicochemical properties of TQ-NC were determined using different machines. TQ was fully incorporated in the highly thermal stable nanoparticles. The nanoparticles showed rapid release of TQ in the acidic medium of the gastric juice. In medium of pH 6.8, TQ-NC exhibited sustained release of TQ over a period of 100 h. The results suggest that TQ-NC nanoparticles have potential application as parenterally administered therapeutic compound. TQ-NC effectively reduce production of inflammatory cytokines by the LPS-stimulated RAW 264.7 cells, indicating that they have anti-inflammatory properties. In conclusion, TQ-NC nanoparticles have the characteristics of efficient carrier for TQ and an effective anti-inflammatory therapeutic compound.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 The Author(s).)
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فهرسة مساهمة: Keywords: Drug release; High-pressure homogenizer; Inflammatory mediators; Nanocomposite; RAW 264.7 cells; Thymoquinone
تواريخ الأحداث: Date Created: 20220509 Latest Revision: 20230916
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9068746
DOI: 10.1016/j.jsps.2022.02.002
PMID: 35527823
قاعدة البيانات: MEDLINE
الوصف
تدمد:1319-0164
DOI:10.1016/j.jsps.2022.02.002