دورية أكاديمية
The Evolving Role of Nucleotide-binding Oligomerisation Domain-like Receptor Pyrin Domain 3 Inflammasome Activation in Vascular Endothelial Cells: A Review.
العنوان: | The Evolving Role of Nucleotide-binding Oligomerisation Domain-like Receptor Pyrin Domain 3 Inflammasome Activation in Vascular Endothelial Cells: A Review. |
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المؤلفون: | Abas R; Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, United Kingdom.; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Basir R; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Mohd Thani S; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Salihan S; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Saat A; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Mohamad Zainal NH; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Mohamad Asri SF; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Ab Razak NI; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Mohd Nor NH; Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia., Kamaruddin NA; Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia. |
المصدر: | The Malaysian journal of medical sciences : MJMS [Malays J Med Sci] 2022 Apr; Vol. 29 (2), pp. 8-17. Date of Electronic Publication: 2022 Apr 21. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Universiti Sains Malaysia Press Country of Publication: Malaysia NLM ID: 101126308 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1394-195X (Print) Linking ISSN: 1394195X NLM ISO Abbreviation: Malays J Med Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: [Pulau Pinang, Malaysia] : Universiti Sains Malaysia Press Original Publication: [Kubang Kerian, Kelantan, Malaysia] : School of Medical Sciences, Universiti Sains Malaysia, |
مستخلص: | In the vascular wall, defence against pathogenic damage requires a group of monocytes, the endothelium, dendritic cells, macrophages and a subsequent involvement of pattern recognition receptors anticipating damage-associated molecular patterns (DAMPs) to initiate an innate immune response. The endothelium plays a crucial role in regulating the duration, location and extent of the inflammatory cascade to ensure a definitive immune defence. Molecular changes in the expression of chemokines and cell adhesion molecules ensure protective responses against infection and injury. The multiprotein oligomer complex nucleotide-binding oligomerisation domain (NOD)-like receptor pyrin domain 3 (NLRP3) inflammasome plays a key role in the activation of inflammatory processes in response to DAMPs and pattern-associated molecular patterns. As a result of NLRP3 inflammasome activation, caspase-1 is activated and interleukin-1β (IL-1β) is produced. Caspase-1 is the main mediator of inflammatory feedback to tissue injury, and it is engaged both in the initiation of the inflammatory response and in the induction of cell death. NLRP3 inflammasome promotes further inflammatory responses and pyroptosis in the vascular endothelium; thus, its optimum regulation is crucial in cardiovascular homeostasis. This review outlines our current perception of the role of NLRP3 in vascular endothelial cells. Competing Interests: Conflicts of Interest None. (© Penerbit Universiti Sains Malaysia, 2022.) |
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فهرسة مساهمة: | Keywords: NLRP3 inflammasome; endothelial cells; inflammation; vascular |
تواريخ الأحداث: | Date Created: 20220509 Latest Revision: 20220716 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9036936 |
DOI: | 10.21315/mjms2022.29.2.2 |
PMID: | 35528818 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1394-195X |
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DOI: | 10.21315/mjms2022.29.2.2 |