دورية أكاديمية
PET-based classification of corticobasal syndrome.
| العنوان: | PET-based classification of corticobasal syndrome. |
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| المؤلفون: | Nakano Y; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan; Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan; Department of Neurology, Chibaken Saiseikai Narashino Hospital, Narashino, Japan., Shimada H; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan; Department of Functional Neurology & Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan., Shinotoh H; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan; Neurology Clinic Chiba, Chiba, Japan., Hirano S; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan; Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan., Tagai K; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Sano Y; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Yamamoto Y; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Endo H; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Matsuoka K; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Takahata K; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Kubota M; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Takado Y; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Kimura Y; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan; National Center for Geriatrics and Gerontology, Obu, Japan., Ichise M; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Ono M; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Sahara N; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Kawamura K; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Zhang MR; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Kuwabara S; Department of Neurology, Chiba University Graduate School of Medicine, Chiba, Japan., Suhara T; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Higuchi M; National Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba, Japan. Electronic address: higuchi.makoto@qst.go.jp. |
| المصدر: | Parkinsonism & related disorders [Parkinsonism Relat Disord] 2022 May; Vol. 98, pp. 92-98. Date of Electronic Publication: 2022 Apr 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kidlington, Oxford, U.K. ; Tarrytown, NY : Elsevier Science, c1995- |
| مواضيع طبية MeSH: | Alzheimer Disease*/metabolism , Corticobasal Degeneration*, Fluorodeoxyglucose F18 ; Humans ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; tau Proteins/metabolism |
| مستخلص: | Introduction: Corticobasal degeneration (CBD) is the most common neuropathological substrate for clinically diagnosed corticobasal syndrome (CBS), while identifying CBD pathology in living individuals has been challenging. This study aimed to examine the capability of positron emission tomography (PET) to detect CBD-type tau depositions and neuropathological classification of CBS. Methods: Sixteen CBS cases diagnosed by Cambridge's criteria and 12 cognitively healthy controls (HCs) underwent PET scans with 11 C-PiB, 11 C-PBB3, and 18 F-FDG, along with T1-weighted magnetic resonance imaging. Amyloid positivity was assessed by visual inspection of 11 C-PiB retentions. Tau positivity was judged by quantitative comparisons of 11 C-PBB3 binding to HCs. Results: Sixteen CBS cases consisted of two cases (13%) with amyloid and tau positivities indicative of Alzheimer's disease (AD) pathologies, 11 cases (69%) with amyloid negativity and tau positivity, and three cases (19%) with amyloid and tau negativities. Amyloid(-), tau(+) CBS cases showed increased retentions of 11 C-PBB3 in the frontoparietal areas, basal ganglia, and midbrain, and reduced metabolism in the precentral gyrus and thalamus relative to HCs. The enhanced tau probe retentions in the frontal gray and white matters partially overlapped with metabolic deficits and atrophy and correlated with Clinical Dementia Rating scores. Conclusions: PET-based classification of CBS was in accordance with previous neuropathological reports on the prevalences of AD, non-AD tauopathies, and others in CBS. The current work suggests that 11 C-PBB3-PET may assist the biological classification of CBS and understanding of links between CBD-type tau depositions and neuronal deteriorations leading to cognitive declines. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: (11)C-PBB3; Amyloid; Corticobasal degeneration/syndrome (CBD/CBS); Positron emission tomography; Tau |
| المشرفين على المادة: | 0 (tau Proteins) 0Z5B2CJX4D (Fluorodeoxyglucose F18) |
| تواريخ الأحداث: | Date Created: 20220509 Date Completed: 20220614 Latest Revision: 20220624 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.parkreldis.2022.04.015 |
| PMID: | 35533530 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-5126 |
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| DOI: | 10.1016/j.parkreldis.2022.04.015 |