دورية أكاديمية
أعرض في EDS

Hepatic Regeneration in Cirrhosis.

التفاصيل البيبلوغرافية
العنوان: Hepatic Regeneration in Cirrhosis.
المؤلفون: Jindal A; Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi 110070, India., Jagdish RK; Consultant Hepatologist, Fortis Hospital, Noida, India., Kumar A; Department of Research, Institute of Liver and Biliary Sciences, New Delhi 110070, India.
المصدر: Journal of clinical and experimental hepatology [J Clin Exp Hepatol] 2022 Mar-Apr; Vol. 12 (2), pp. 603-616. Date of Electronic Publication: 2021 Sep 04.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: India NLM ID: 101574137 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0973-6883 (Print) Linking ISSN: 09736883 NLM ISO Abbreviation: J Clin Exp Hepatol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Gurgaon, India : Elsevier, 2011-
مستخلص: End-stage liver disease is characterized by massive hepatocyte death resulting in clinical decompensation and organ failures. Clinical consequences in cirrhosis are the results of the loss of functional hepatocytes and excessive scarring. The only curative therapy in advanced cirrhosis is orthotropic liver transplantation, but the clinical demand outweighs the availability of acceptable donor organs. Moreover, this also necessitates lifelong immunosuppression and carries associated risks. The liver has a huge capability for regeneration. Self-replication of quiescent differentiated hepatocytes and cholangiocytes occurs in patients with acute liver injury. Due to limited hepatocyte self-renewal capacity in advanced cirrhosis, great interest has therefore been shown in characterizing the possible role of hepatic progenitor cells and bone marrow-derived stem cells to therapeutically aid this process. Transplantation of cells from various sources that can be properly differentiated into functional liver cells or use of growth factors for ex-vivo expansion of progenitor cells is needed at utmost priority. Multiple researches over the last two decades have aided researchers in refining proliferation, differentiation, and storage techniques and understand the functionality of these cells for use in clinical practice. However, these cell-based therapies are still experimental and have to be used in trial settings.
(© 2021 Indian National Association for Study of the Liver. Published by Elsevier B.V. All rights reserved.)
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فهرسة مساهمة: Keywords: Ang2, angiopoietin 2; BM, Bone marrow; BM-MNCs, bone marrow mononuclear cells; BMSC, bone marrow stem cells; DAMPs, Damage associated molecular patterns; EPCs, endothelial progenitor cells; ESRP2, epithelial splicing regulatory protein 2; GCSF; HGF, hepatocyte growth factor; HPC, Hepatocyte progenitor cells; HSCs, hematopoietic stem cells; Hh, Hedgehog; HybHP, hybrid periportal hepatocytes; MMP, matrix metalloprotease; MSCs, mesenchymal stromal cells; OLT, Orthotropic liver transplantation; PAMPs, Pathogen associated molecular patterns; SAH, severe alcoholic hepatitis; SDF1, stromal-derived factor 1; TNFSF12, tumor necrosis factor ligand superfamily member 12; Terthigh, high Telomerase reverse transcriptase; [Hnf4a], Hepatocyte Nuclear Factor 4 Alpha; [Mfsd2a], Major Facilitator Superfamily Domain containing 2A; acute liver failure; chronic liver diseases; hepatocyte transplant; liver regeneration
تواريخ الأحداث: Date Created: 20220510 Latest Revision: 20230302
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9077225
DOI: 10.1016/j.jceh.2021.08.029
PMID: 35535091
قاعدة البيانات: MEDLINE
الوصف
تدمد:0973-6883
DOI:10.1016/j.jceh.2021.08.029