Matrix-assisted autologous chondrocyte transplantation for treatment of focal chondral lesions in the knee: the Hospital Israelita Albert Einstein experience.

التفاصيل البيبلوغرافية
العنوان:	Matrix-assisted autologous chondrocyte transplantation for treatment of focal chondral lesions in the knee: the Hospital Israelita Albert Einstein experience.
المؤلفون:	Zorzi AR; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Antonioli E; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Kaleka CC; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Cohen M; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Godoy JAP; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Kondo AT; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Kutner JM; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Lenza M; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil., Ferretti M; Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
المصدر:	Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2022 May 06; Vol. 20, pp. eAO6819. Date of Electronic Publication: 2022 May 06 (Print Publication: 2022).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Instituto de Ensino e Pesquisa Albert Einstein Country of Publication: Brazil NLM ID: 101281800 Publication Model: eCollection Cited Medium: Internet ISSN: 2317-6385 (Electronic) Linking ISSN: 16794508 NLM ISO Abbreviation: Einstein (Sao Paulo) Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: São Paulo, SP : Instituto de Ensino e Pesquisa Albert Einstein
مواضيع طبية MeSH:	Cartilage, Articular/injuries , Cartilage, Articular/surgery , Knee Injuries/diagnostic imaging , Knee Injuries/surgery, Chondrocytes ; Follow-Up Studies ; Hospitals ; Humans ; Knee Joint/surgery ; Transplantation, Autologous
مستخلص:	Objective: Phase 1 clinical trial to determine feasibility, safety, and efficacy of a new advanced cell therapy product for treatment of knee articular cartilage injuries. Methods: Three participants with knee focal chondral lesions were included, with no signs of osteoarthritis. Chondrocytes were obtained through knee arthroscopy, cultured in collagen membrane for 3 weeks at the laboratory, subjected to tests to release the cell therapy product, and implanted. All patients underwent a specific 3-month rehabilitation protocol, followed by assessments using functional and imaging scales. The main outcome was the incidence of severe adverse events. Results: Three participants were included and completed the 2-year follow-up. There was one severe adverse event, venous thrombosis of distal leg veins, which was no associated with therapy, was treated and left no sequelae. The clinical and radiological scales showed improvement in the three cases. Conclusion: The preliminary results, obtained with the described methodology, allow concluding that this product of advanced cell therapy is safe and feasible. ReBEC platform registration number: RBR-6fgy76.
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تواريخ الأحداث:	Date Created: 20220511 Date Completed: 20220516 Latest Revision: 20220716
رمز التحديث:	20231215
مُعرف محوري في PubMed:	PMC9070989
DOI:	10.31744/einstein_journal/2022AO6819
PMID:	35544896
قاعدة البيانات:	MEDLINE

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تدمد:	2317-6385
DOI:	10.31744/einstein_journal/2022AO6819