دورية أكاديمية
Risk factors of rejection after penetrating keratoplasty: a retrospective monocentric study.
| العنوان: | Risk factors of rejection after penetrating keratoplasty: a retrospective monocentric study. |
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| المؤلفون: | Debourdeau E; Department of Ophthalmology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, F-34000, Montpellier, France. eloidebourdeau@gmail.com.; Montpellier University, F-34000, Montpellier, France. eloidebourdeau@gmail.com.; Institute for Neurosciences of Montpellier INM, Univ. Montpellier, INSERM, F-34091, Montpellier, France. eloidebourdeau@gmail.com., Builles N; Department of Cell and Tissue Engineering, Univ. Montpellier, CHU Montpellier, Montpellier, France., Couderc G; Department of Cell and Tissue Engineering, Univ. Montpellier, CHU Montpellier, Montpellier, France., Boulhic J; Department of Ophthalmology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, F-34000, Montpellier, France.; Montpellier University, F-34000, Montpellier, France., Chamard C; Department of Ophthalmology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, F-34000, Montpellier, France.; Montpellier University, F-34000, Montpellier, France.; Institute for Neurosciences of Montpellier INM, Univ. Montpellier, INSERM, F-34091, Montpellier, France., Villain M; Department of Ophthalmology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, F-34000, Montpellier, France.; Montpellier University, F-34000, Montpellier, France., Babeau F; Department of Ophthalmology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, F-34000, Montpellier, France.; Montpellier University, F-34000, Montpellier, France., Daien V; Department of Ophthalmology, Gui de Chauliac Hospital, 80 avenue Augustin Fliche, F-34000, Montpellier, France. v-daien@chu-montpellier.fr.; Montpellier University, F-34000, Montpellier, France. v-daien@chu-montpellier.fr.; Institute for Neurosciences of Montpellier INM, Univ. Montpellier, INSERM, F-34091, Montpellier, France. v-daien@chu-montpellier.fr.; Sydney Medical School, The Save Sight Institute, The University of Sydney, Sydney, NSW, Australia. v-daien@chu-montpellier.fr. |
| المصدر: | Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2022 Nov; Vol. 260 (11), pp. 3627-3638. Date of Electronic Publication: 2022 May 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8205248 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-702X (Electronic) Linking ISSN: 0721832X NLM ISO Abbreviation: Graefes Arch Clin Exp Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin ; New York : Springer-Verlag, c1982- |
| مواضيع طبية MeSH: | Corneal Diseases*/diagnosis , Corneal Diseases*/surgery , Keratoconus*/surgery , Keratitis*, Humans ; Male ; Middle Aged ; Female ; Keratoplasty, Penetrating/methods ; Retrospective Studies ; Graft Survival ; Graft Rejection/diagnosis ; Graft Rejection/etiology ; Graft Rejection/surgery ; Risk Factors |
| مستخلص: | Purpose: To assess risk factors of rejection after penetrating keratoplasty (PKP). Methods: This retrospective monocentric study assessed risk factors for rejection in patients who underwent PKP at Montpellier University Hospital between June 2005 and September 2018. Graft and donor data were obtained from our tissue bank in Montpellier. Clinical data of recipients were recorded from medical files. Survival was estimated by the Kaplan-Meir method. Potential risk factors of rejection were assessed by multivariate Cox proportional hazards analysis, estimating hazard ratios (HR) and 95% confidence intervals (CI). Results: Among the 316 consecutive patients (59% male, mean SD] age 52 [17]), 360 eyes underwent PKP. Indications for PKP were bullous keratopathy (27%), infectious keratitis (20%), and keratoconus (15%). The median follow-up was 44 months (IQR 22-73). The overall graft survival and irreversible rejection rate at 5 years were 70% and 29%, respectively. Factors associated with risk of rejection were prior indication for graft rejection (SHR [CI 95%] = 7.8 [2.6-23.1]), trauma (SHR [CI 95%] = 3.6 [1.1-11.7]), and infectious keratitis (SHR [CI 95%] = 2.7 [1.2-11.1]), history of corneal neovascularization (SHR [CI 95%] = 2.1 [1.2-3.8]), hypertonia (SHR [CI 95%] = 2.8 [1.8-4.3]), and mixed sex matching (SHR [CI 95%] = 2.0 [1.01-4.0]). Conclusion: The significant risk factors of graft rejection after PKP found in this study agree with those from major international cohorts: prior indication for graft rejection, history of neovascularization and high intraocular pressure. Sex matching donor-recipient is a most recent parameter in the literature confirmed by the present analysis. Trial Registration: ClinicalTrials.gov Identifier: NCT04791696. (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Graft rejection; Graft survival; Keratoplasty; Penetrating; Risk factors; Tissue donors |
| سلسلة جزيئية: | ClinicalTrials.gov NCT04791696 |
| تواريخ الأحداث: | Date Created: 20220513 Date Completed: 20221021 Latest Revision: 20221021 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00417-022-05691-w |
| PMID: | 35546638 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1435-702X |
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| DOI: | 10.1007/s00417-022-05691-w |