Facile fabrication of water-dispersible nanocomposites based on hexa- peri -hexabenzocoronene and Fe 3 O 4 for dual mode imaging (fluorescent/MR) and drug delivery.

التفاصيل البيبلوغرافية
العنوان:	Facile fabrication of water-dispersible nanocomposites based on hexa- peri -hexabenzocoronene and Fe 3 O 4 for dual mode imaging (fluorescent/MR) and drug delivery.
المؤلفون:	Song MM; School of Basic Medical Sciences, Anhui Medical University 81 Meishan Road Hefei Anhui PR China liurui@ahmu.edu.cn shenyx@ahmu.edu.cn +86-551-65161138 +86-551-65113776.; Biopharmaceutical Research Institute, Anhui Medical University 81 Meishan Road Hefei Anhui PR China., Xiang HH; School of Basic Medical Sciences, Anhui Medical University 81 Meishan Road Hefei Anhui PR China liurui@ahmu.edu.cn shenyx@ahmu.edu.cn +86-551-65161138 +86-551-65113776.; The First Affiliated Hospital, Anhui Medical University 218 Jixi Road Hefei Anhui PR China., Fei MY; School of Basic Medical Sciences, Anhui Medical University 81 Meishan Road Hefei Anhui PR China liurui@ahmu.edu.cn shenyx@ahmu.edu.cn +86-551-65161138 +86-551-65113776.; The First Affiliated Hospital, Anhui Medical University 218 Jixi Road Hefei Anhui PR China., Lu DP; School of Pharmacy, Anhui Medical University 81 Meishan Road Hefei Anhui PR China., Jiang TC; School of Basic Medical Sciences, Anhui Medical University 81 Meishan Road Hefei Anhui PR China liurui@ahmu.edu.cn shenyx@ahmu.edu.cn +86-551-65161138 +86-551-65113776.; Biopharmaceutical Research Institute, Anhui Medical University 81 Meishan Road Hefei Anhui PR China., Yu YQ; The First Affiliated Hospital, Anhui Medical University 218 Jixi Road Hefei Anhui PR China., Liu R; School of Basic Medical Sciences, Anhui Medical University 81 Meishan Road Hefei Anhui PR China liurui@ahmu.edu.cn shenyx@ahmu.edu.cn +86-551-65161138 +86-551-65113776., Shen YX; School of Basic Medical Sciences, Anhui Medical University 81 Meishan Road Hefei Anhui PR China liurui@ahmu.edu.cn shenyx@ahmu.edu.cn +86-551-65161138 +86-551-65113776.; Biopharmaceutical Research Institute, Anhui Medical University 81 Meishan Road Hefei Anhui PR China.
المصدر:	RSC advances [RSC Adv] 2018 Dec 05; Vol. 8 (71), pp. 40554-40563. Date of Electronic Publication: 2018 Dec 05 (Print Publication: 2018).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: Cambridge [England] : Royal Society of Chemistry, [2011]-
مستخلص:	The facile fabrication of multifunctional nanocomposites (Fe 3 O 4 /HBC@F127) consisting of superparamagnetic Fe 3 O 4 nanoparticles and fluorescent organic hexa- peri -hexabenzocoronene (HBC) molecules incorporated in block copolymer diacylphospholipid-polyethyleneglycol F127 have been demonstrated for dual mode imaging (fluorescent/MR) and drug delivery. The obtained nanocomposites were water-dispersible, stable and biocompatible, as confirmed by dynamic light scattering (DLS) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Relativity measurements showed a T 2 relaxivity ( r 2 ) of 214.61 mM ^-1 s ^-1 , which may be used as T 2 -weighted MR imaging agents. In vitro imaging studies indicated that the nanocomposites had good MR and fluorescence imaging effects with low cytotoxicity. Besides, the developed nanocomposites could also be applied as drug delivery vehicles. Doxorubicin (DOX) loaded Fe 3 O 4 /HBC@F127 nanocomposites significantly inhibited the growth of human hepatoma cells (HepG2). These findings suggested that the facile synthesized multifunctional nanocomposites may be used as a platform for dual mode imaging (both MR and fluorescence) and drug delivery. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
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تواريخ الأحداث:	Date Created: 20220513 Latest Revision: 20220519
رمز التحديث:	20221213
مُعرف محوري في PubMed:	PMC9091618
DOI:	10.1039/c8ra08425d
PMID:	35557926
قاعدة البيانات:	MEDLINE

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تدمد:	2046-2069
DOI:	10.1039/c8ra08425d