دورية أكاديمية
أعرض في EDS

Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon.

التفاصيل البيبلوغرافية
العنوان: Common BMI and diabetes-related genetic variants: A pilot study among indigenous people in the Brazilian Amazon.
المؤلفون: Diniz IG; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil., Noce RRD; Universidade Federal do Pará, Instituto de Ciências da Saúde, Faculdade de Nutrição, Belém, PA, Brazil., Pereira AP; Universidade Federal do Pará, Instituto de Ciências da Saúde, Faculdade de Nutrição, Belém, PA, Brazil., Silva ANLMD; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil., Sacuena ERP; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil., Lemes RB; Universidade de São Paulo, Departamento de Genética e Biologia Evolutiva, São Paulo, SP, Brazil., Cardoso-Costa GL; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil., Araújo GS; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil., Machado JLP; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil., Figueiredo FAPL; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil., Hümemeier T; Universidade de São Paulo, Departamento de Genética e Biologia Evolutiva, São Paulo, SP, Brazil., Guerreiro JF; Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
المصدر: Genetics and molecular biology [Genet Mol Biol] 2022 May 11; Vol. 45 (2), pp. e20210153. Date of Electronic Publication: 2022 May 11 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sociedade Brasileira de Genética Country of Publication: Brazil NLM ID: 100883590 Publication Model: eCollection Cited Medium: Print ISSN: 1415-4757 (Print) Linking ISSN: 14154757 NLM ISO Abbreviation: Genet Mol Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Ribeirão Preto, SP, Brazil : Sociedade Brasileira de Genética, 1998-
مستخلص: This study was carried out to investigate the frequency of genetic variants related to body mass index (BMI) and type 2 diabetes (T2D) and evaluating the potential impact of risk alleles on susceptibility to these disorders in six indigenous peoples from Brazilian Amazon region. The majority of Fst values for pairwise population comparisons among the indigenous groups are low or moderate. The indigenous people show high values of differentiation with Africans, Europeans and Southeast Asians and moderate values with East Asian and American populations, as expected. The allelic frequencies among indigenous indicate that the majority of associations observed with T2D in continental populations can be replicated in native Amazonians. The genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians, while the estimates obtained for obesity are low, probably due to the low frequencies of the risk allele of the FTO gene found in our samples. ADRB3-rs4994 and ABCC8-rs1799854 genes showed a significant association with BMI and waist circumference, and the KCNJ11-rs5219 gene with hyperglycemia. These results emphasize the importance of knowing the genetic variability underlying complex genetic diseases in indigenous peoples and the search for particular or rare variants.
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تواريخ الأحداث: Date Created: 20220513 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9104643
DOI: 10.1590/1678-4685-GMB-2021-0153
PMID: 35560161
قاعدة البيانات: MEDLINE
الوصف
تدمد:1415-4757
DOI:10.1590/1678-4685-GMB-2021-0153