دورية أكاديمية
Exosomal miRNAs as a Promising Source of Biomarkers in Colorectal Cancer Progression.
العنوان: | Exosomal miRNAs as a Promising Source of Biomarkers in Colorectal Cancer Progression. |
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المؤلفون: | Bakhsh T; Department of Biology, Faculty of Science, Jeddah University, Jeddah 21589, Saudi Arabia., Alhazmi S; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alburae NA; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Farsi A; Department of Surgry, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Alzahrani F; King Fahd Medical Research Center, Embryonic Stem Cells Unit, Department of Biochemistry, Faculty of Science, King AbdulAziz University, Jeddah 21589, Saudi Arabia.; Centre of Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Choudhry H; Centre of Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Bahieldin A; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2022 Apr 27; Vol. 23 (9). Date of Electronic Publication: 2022 Apr 27. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Colorectal Neoplasms*/diagnosis , Colorectal Neoplasms*/genetics , Exosomes*/genetics , Exosomes*/pathology , Extracellular Vesicles*/pathology , MicroRNAs*/genetics, Biomarkers, Tumor/genetics ; Female ; Humans ; Male ; Tumor Microenvironment/genetics |
مستخلص: | Colorectal cancer (CRC) is the third most common type of cancer worldwide amongst males and females. CRC treatment is multidisciplinary, often including surgery, chemotherapy, and radiotherapy. Early diagnosis of CRC can lead to treatment initiation at an earlier stage. Blood biomarkers are currently used to detect CRC, but because of their low sensitivity and specificity, they are considered inadequate diagnostic tools and are used mainly for following up patients for recurrence. It is necessary to detect novel, noninvasive, specific, and sensitive biomarkers for the screening and diagnosis of CRC at earlier stages. The tumor microenvironment (TME) has an essential role in tumorigenesis; for example, extracellular vesicles (EVs) such as exosomes can play a crucial role in communication between cancer cells and different components of TME, thereby inducing tumor progression. The importance of miRNAs that are sorted into exosomes has recently attracted scientists' attention. Some unique sequences of miRNAs are favorably packaged into exosomes, and it has been illustrated that particular miRNAs can be directed into exosomes by special mechanisms that occur inside the cells. This review illustrates and discusses the sorted and transported exosomal miRNAs in the CRC microenvironment and their impact on CRC progression as well as their potential use as biomarkers. |
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فهرسة مساهمة: | Keywords: biomarkers; colorectal cancer; exosomes; extracellular vesicles; miRNAs; tumor microenvironment |
المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (MicroRNAs) |
تواريخ الأحداث: | Date Created: 20220514 Date Completed: 20220517 Latest Revision: 20220716 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9103063 |
DOI: | 10.3390/ijms23094855 |
PMID: | 35563246 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
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DOI: | 10.3390/ijms23094855 |