دورية أكاديمية
أعرض في EDS

Beta interferons from the extant camelids: Unique among eutherian mammals.

التفاصيل البيبلوغرافية
العنوان: Beta interferons from the extant camelids: Unique among eutherian mammals.
المؤلفون: Premraj A; Camel Biotechnology Center, Presidential Camels & Camel Racing Affairs Centre, Department of the President's Affairs, PO Box 17292, Al Ain, United Arab Emirates., Aleyas AG; Camel Biotechnology Center, Presidential Camels & Camel Racing Affairs Centre, Department of the President's Affairs, PO Box 17292, Al Ain, United Arab Emirates., Nautiyal B; Camel Biotechnology Center, Presidential Camels & Camel Racing Affairs Centre, Department of the President's Affairs, PO Box 17292, Al Ain, United Arab Emirates., Rasool TJ; Camel Biotechnology Center, Presidential Camels & Camel Racing Affairs Centre, Department of the President's Affairs, PO Box 17292, Al Ain, United Arab Emirates. Electronic address: tjrasool@gmail.com.
المصدر: Developmental and comparative immunology [Dev Comp Immunol] 2022 Aug; Vol. 133, pp. 104443. Date of Electronic Publication: 2022 May 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7708205 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0089 (Electronic) Linking ISSN: 0145305X NLM ISO Abbreviation: Dev Comp Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown Ny : Elsevier Science
Original Publication: Elmsford, N. Y., Pergamon Press., 1977-2004.
مواضيع طبية MeSH: COVID-19* , Middle East Respiratory Syndrome Coronavirus*/genetics, Animals ; Antiviral Agents ; Camelus ; Eutheria ; Humans ; Interferon-beta/genetics ; Pandemics ; Zoonoses
مستخلص: The COVID-19 pandemic is a wake-up call on the zoonotic viral spillover events and the need to be prepared for future outbreaks. Zoonotic RNA viruses like the Middle East respiratory syndrome coronavirus (MERS-CoV) are potential pathogens that could trigger the next pandemic. Dromedary camels are the only known animal source of MERS-CoV zoonotic infections, but little is known about the molecular antiviral response in this species. IFN-β and other type-I interferons provide the first line of defense against invading pathogens in the host immune response. We identified the IFNB gene of the dromedary camel and all extant members of the family Camelidae. Camelid IFN-β is unique with an even number of cysteines in the mature protein compared to other eutherian mammals with an odd number of cysteines. The viral mimetic poly(I:C) strongly induced IFN-β expression in camel kidney cells. Induction of IFN-β expression upon infection with camelpox virus was late and subdued when compared to poly(I:C) treatment. Prokaryotically expressed recombinant dromedary IFN-β induced expression of IFN-responsive genes in camel kidney cells. Further, recombinant IFN-β conferred antiviral resistance to camel kidney cells against the cytopathic effects of the camelpox virus, an endemic zoonotic pathogen. IFN-β from this unique group of mammals will offer insights into antiviral immune mechanisms and aid in the development of specific antivirals against pathogens that have the potential to be the next zoonotic pandemic.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
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فهرسة مساهمة: Keywords: Antiviral; Coronavirus; Dromedary camel; Interferon; Poxvirus; Zoonosis
المشرفين على المادة: 0 (Antiviral Agents)
77238-31-4 (Interferon-beta)
تواريخ الأحداث: Date Created: 20220514 Date Completed: 20220603 Latest Revision: 20230124
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9095258
DOI: 10.1016/j.dci.2022.104443
PMID: 35568245
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0089
DOI:10.1016/j.dci.2022.104443