دورية أكاديمية
أعرض في EDS

Ameliorative effect of nanocurcumin and Saccharomyces cell wall alone and in combination against aflatoxicosis in broilers.

التفاصيل البيبلوغرافية
العنوان: Ameliorative effect of nanocurcumin and Saccharomyces cell wall alone and in combination against aflatoxicosis in broilers.
المؤلفون: Ashry A; Biochemistry Dept., Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt. AyaAshry@mau.edu.eg., Taha NM; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, Egypt., Lebda MA; Department of Biochemistry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, 21526, Egypt., Abdo W; Pathology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafr El-Sheikh, 33516, Egypt., El-Diasty EM; Mycology and Mycotoxins Department, Animal Health Research Institute (ARC), Dokki, Egypt., Fadl SE; Biochemistry Dept., Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt., Morsi Elkamshishi M; Department of Animal Hygiene and Zoonoses, Faculty of Veterinary Medicine, Matrouh University, Matrouh, Egypt.
المصدر: BMC veterinary research [BMC Vet Res] 2022 May 14; Vol. 18 (1), pp. 178. Date of Electronic Publication: 2022 May 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2005-
مواضيع طبية MeSH: Aflatoxins*/toxicity , Foodborne Diseases*/veterinary , Saccharomyces*/metabolism, Aflatoxin B1/metabolism ; Aflatoxin B1/toxicity ; Animal Feed/analysis ; Animals ; Cell Wall/metabolism ; Chickens ; Diet/veterinary ; Dietary Supplements
مستخلص: Background: The adverse effect of aflatoxin in broilers is well known. However, dietary supplementation of Saccharomyces cell wall and/or Nanocurcumin may decrease the negative effect of aflatoxin B1 because of the bio-adsorbing feature of the functional ingredients in Yeast Cell Wall and the detoxification effect of curcumin nanoparticles. The goal of this study was to see how Saccharomyces cell wall/Nanocurcumin alone or in combination with the aflatoxin-contaminated diet ameliorated the toxic effects of aflatoxin B1 on broiler development, blood and serum parameters, carcass traits, histology, immune histochemistry, liver gene expression, and aflatoxin residue in the liver and muscle tissue of broilers for 35 days. Moreover, the withdrawal time of aflatoxin was measured after feeding the aflatoxicated group an aflatoxin-free diet. Broiler chicks one day old were distributed into five groups according to Saccharomyces cell wall and/or nanocurcumin with aflatoxin supplementation. The G1 group was given a formulated diet without any supplements. The G2 group was supplemented with aflatoxin (0.25 mg/kg diet) in the formulated diet. The G3 group was supplemented with aflatoxin (0.25 mg/kg diet) and Saccharomyces cell wall (1 kg/ton diet) in the formulated diet. The G4 group was supplemented with aflatoxin (0.25 mg/kg diet) and nanocurcumin (400 mg/kg) in the formulated diet. The G5 group was supplemented with aflatoxin (0.25 mg/kg diet) and Saccharomyces cell wall (1 kg/ton diet) in combination with nanocurcumin (200 mg/kg) in the formulated diet.
Results: According to the results of this study, aflatoxin supplementation had a detrimental impact on the growth performance, blood and serum parameters, carcass traits, and aflatoxin residue in the liver and muscle tissue of broilers. In addition, aflatoxin supplementation led to a liver injury that was indicated by serum biochemistry and pathological lesions in the liver tissue. Moreover, the shortening of villi length in aflatoxicated birds resulted in a decrease in both the crypt depth ratio and the villi length ratio. The expression of CYP1A1 and Nrf2 genes in the liver tissue increased and decreased, respectively, in the aflatoxicated group. In addition, the aflatoxin residue was significantly (P ≤ 0.05) decreased in the liver tissue of the aflatoxicated group after 2 weeks from the end of the experiment.
Conclusion: Saccharomyces cell wall alone or with nanocurcumin attenuated these negative effects and anomalies and improved all of the above-mentioned metrics.
(© 2022. The Author(s).)
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فهرسة مساهمة: Keywords: Aflatoxin; Biochemistry; Liver gene; Nanocurcumin; Pathology; Saccharomyces cell wall
المشرفين على المادة: 0 (Aflatoxins)
9N2N2Y55MH (Aflatoxin B1)
تواريخ الأحداث: Date Created: 20220515 Date Completed: 20220517 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9107200
DOI: 10.1186/s12917-022-03256-x
PMID: 35568841
قاعدة البيانات: MEDLINE
الوصف
تدمد:1746-6148
DOI:10.1186/s12917-022-03256-x