دورية أكاديمية
A prospective trial of CT-guided percutaneous microwave ablation for lung tumors.
العنوان: | A prospective trial of CT-guided percutaneous microwave ablation for lung tumors. |
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المؤلفون: | Reisenauer JS; Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA., Eiken PW; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Callstrom MR; Department of Radiology, Mayo Clinic, Rochester, MN, USA., Johnson GB; Department of Radiology, Mayo Clinic, Rochester, MN, USA.; Department of Immunology, Mayo Clinic, Rochester, MN, USA., Pierson K; Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA., Lechtenberg B; Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA., Blackmon SH; Division of Thoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA. |
المصدر: | Journal of thoracic disease [J Thorac Dis] 2022 Apr; Vol. 14 (4), pp. 939-951. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: AME Publishing Company Country of Publication: China NLM ID: 101533916 Publication Model: Print Cited Medium: Print ISSN: 2072-1439 (Print) Linking ISSN: 20721439 NLM ISO Abbreviation: J Thorac Dis Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: Hong Kong : AME Publishing Company Original Publication: Hong Kong : Pioneer Bioscience Pub. Co. |
مستخلص: | Background: Percutaneous ablation is an alternative treatment for lung cancer in non-operable patients. This is a prospective clinical trial for percutaneous microwave ablation (pMWA) of biopsy-proven lung cancer to demonstrate safety and efficacy. Methods: A prospective trial from 6-1-2016 to 1-1-2019 enrolled patients with biopsy-proven primary or metastatic lung cancer <3 cm in size and 1 cm away from the pleura for pMWA with the Emprint Ablation System with Thermosphere Technology for Phase I analysis, (Clinicaltrials.gov; #NCT0267302). Patients were followed for 1 year with PET/CT and PET/MR to determine patterns of recurrence and efficacy of ablation. Results: After 12 patients consented for biopsy, 6 patients underwent treatment of 7 lesions, 3/6 women, median age of 67 (IQR, 65-70) years, body mass index (BMI): 27.8 (IQR, 21.4-32.1) kg/m 2 , lesion distance to pleura 24.4 (IQR, 13-38) mm, lesion size of 10.7 (IQR, 6-14) mm, and ablation duration time 5.9 (IQR, 3-10) minutes. pMWA were completed at 75 W. Twelve adverse events were reported (1 Grade 3, 3 Grade 2, and 8 Grade 1 events) with Grade 4 or 5 events. Mean % change after ablation in forced expiratory volume in one second (FEV1) was -2% and diffusion capacity for carbon monoxide (DLCO) was -1%. After 2-3 months, the lesions would decrease in size, rim thickness, fluorodeoxyglucose (FDG) activity, and T2 signal. FDG activity after 6 months was below blood pool in all cases. The ablation zones stabilized by 6-12 months. One patient expired during the study from pneumonia unrelated to ablation without local recurrence. Of the seven ablations during the 1 year follow-up, there was local tumor recurrence at 271 days following ablation at the apex of the ablation zone, subsequently successfully treated with percutaneous cryoablation (Cryo). Conclusions: pMWA appears to be a safe and effective mechanism for treatment of primary and secondary tumors of the lung, with possible preservation of pulmonary function. Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-21-1636/coif) and report that financial support in the amount of $200,000 was provided by Covidien for conducting this study. The authors have no other conflicts of interest to declare. (2022 Journal of Thoracic Disease. All rights reserved.) |
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فهرسة مساهمة: | Keywords: Lung cancer; ablation; lung ablation; metastasectomy |
تواريخ الأحداث: | Date Created: 20220516 Latest Revision: 20220519 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC9096293 |
DOI: | 10.21037/jtd-21-1636 |
PMID: | 35572874 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-1439 |
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DOI: | 10.21037/jtd-21-1636 |