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Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications.

التفاصيل البيبلوغرافية
العنوان: Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications.
المؤلفون: Recktenwald SM; Experimental Physics, Saarland University, Saarbruecken, Germany., Lopes MGM; Experimental Physics, Saarland University, Saarbruecken, Germany.; Cysmic GmbH, Saarbruecken, Germany., Peter S; Experimental Physics, Saarland University, Saarbruecken, Germany.; Theoretical Medicine and Biosciences, Saarland University, Saarbruecken, Germany., Hof S; Experimental Physics, Saarland University, Saarbruecken, Germany.; Theoretical Medicine and Biosciences, Saarland University, Saarbruecken, Germany., Simionato G; Experimental Physics, Saarland University, Saarbruecken, Germany.; Institute for Clinical and Experimental Surgery, Saarland University, Campus University Hospital, Homburg, Germany., Peikert K; Translational Neurodegeneration Section 'Albrecht-Kossel', Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany., Hermann A; Translational Neurodegeneration Section 'Albrecht-Kossel', Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany.; DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen, Research Site Rostock/Greifswald, Rostock, Germany.; Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany., Danek A; Neurologische Klinik und Poliklinik, Ludwig-Maximilians-University, Munich, Germany., van Bentum K; MVZ Saarpfalz, Homburg, Germany., Eichler H; Institute for Clinical Hemostaseology and Transfusion Medicine, Saarland University and Saarland University Hospital, Homburg, Germany., Wagner C; Experimental Physics, Saarland University, Saarbruecken, Germany.; Department of Physics and Materials Science, University of Luxembourg, Luxembourg City, Luxembourg., Quint S; Experimental Physics, Saarland University, Saarbruecken, Germany.; Cysmic GmbH, Saarbruecken, Germany., Kaestner L; Experimental Physics, Saarland University, Saarbruecken, Germany.; Theoretical Medicine and Biosciences, Saarland University, Saarbruecken, Germany.
المصدر: Frontiers in physiology [Front Physiol] 2022 Apr 27; Vol. 13, pp. 884690. Date of Electronic Publication: 2022 Apr 27 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: In many medical disciplines, red blood cells are discovered to be biomarkers since they "experience" various conditions in basically all organs of the body. Classical examples are diabetes and hypercholesterolemia. However, recently the red blood cell distribution width (RDW), is often referred to, as an unspecific parameter/marker (e.g., for cardiac events or in oncological studies). The measurement of RDW requires venous blood samples to perform the complete blood cell count (CBC). Here, we introduce Erysense, a lab-on-a-chip-based point-of-care device, to evaluate red blood cell flow properties. The capillary chip technology in combination with algorithms based on artificial neural networks allows the detection of very subtle changes in the red blood cell morphology. This flow-based method closely resembles in vivo conditions and blood sample volumes in the sub-microliter range are sufficient. We provide clinical examples for potential applications of Erysense as a diagnostic tool [here: neuroacanthocytosis syndromes (NAS)] and as cellular quality control for red blood cells [here: hemodiafiltration (HDF) and erythrocyte concentrate (EC) storage]. Due to the wide range of the applicable flow velocities (0.1-10 mm/s) different mechanical properties of the red blood cells can be addressed with Erysense providing the opportunity for differential diagnosis/judgments. Due to these versatile properties, we anticipate the value of Erysense for further diagnostic, prognostic, and theragnostic applications including but not limited to diabetes, iron deficiency, COVID-19, rheumatism, various red blood cell disorders and anemia, as well as inflammation-based diseases including sepsis.
Competing Interests: SQ is the CEO of and ML is employed by the start-up Cysmic GmbH. SMR, GS, and LK are shareholders of Cysmic GmbH. Erysense is a product of the Cysmic GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Recktenwald, Lopes, Peter, Hof, Simionato, Peikert, Hermann, Danek, van Bentum, Eichler, Wagner, Quint and Kaestner.)
References: Lab Chip. 2020 Jan 21;20(2):226-235. (PMID: 31796943)
IEEE J Biomed Health Inform. 2022 Mar;26(3):1318-1328. (PMID: 34388103)
Orphanet J Rare Dis. 2011 Oct 25;6:68. (PMID: 22027213)
PLoS Comput Biol. 2018 Jun 15;14(6):e1006278. (PMID: 29906283)
Int J Mol Sci. 2017 Sep 08;18(9):. (PMID: 28885563)
Biomolecules. 2021 May 12;11(5):. (PMID: 34066168)
Soft Matter. 2018 Mar 14;14(11):2032-2043. (PMID: 29473072)
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17063-8. (PMID: 17940021)
Lab Chip. 2021 Dec 21;22(1):26-39. (PMID: 34874395)
J Thorac Cardiovasc Surg. 2020 Dec;160(6):1505-1514.e3. (PMID: 31813538)
PLoS One. 2021 Nov 12;16(11):e0259267. (PMID: 34767588)
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21381-21390. (PMID: 32839303)
Blood Transfus. 2019 Jan;17(1):27-52. (PMID: 30653459)
Biomicrofluidics. 2020 Apr 21;14(2):024115. (PMID: 32341726)
Transfusion. 2015 Jan;55(1):205-19. (PMID: 25130459)
Crit Care. 2013 Apr 08;17(2):R66. (PMID: 23566599)
Blood. 2021 Apr 29;137(17):2285-2298. (PMID: 33657208)
Front Physiol. 2018 Jun 01;9:656. (PMID: 29910743)
Can J Physiol Pharmacol. 2018 Mar;96(3):249-257. (PMID: 28854342)
Sci Rep. 2021 Jan 12;11(1):604. (PMID: 33436749)
Am J Physiol. 1995 Nov;269(5 Pt 2):H1713-22. (PMID: 7503269)
Intensive Care Med. 2003 Jul;29(7):1052-61. (PMID: 12802488)
Transfus Med Hemother. 2022 Jan 25;49(1):4-12. (PMID: 35221863)
Vox Sang. 2015 Oct;109(3):221-30. (PMID: 25900518)
Front Med (Lausanne). 2021 Dec 14;8:741407. (PMID: 34970557)
Transfusion. 2008 Jul;48(7):1478-85. (PMID: 18482180)
Front Physiol. 2020 May 26;11:387. (PMID: 32528298)
Eur J Med Genet. 2018 Nov;61(11):699-705. (PMID: 29253590)
Front Physiol. 2017 Dec 05;8:979. (PMID: 29259557)
Commun Biol. 2021 Mar 2;4(1):271. (PMID: 33654170)
J Biomech. 2015 Nov 26;48(15):4065-4072. (PMID: 26477408)
Biophys J. 2021 Jul 20;120(14):2838-2847. (PMID: 34087216)
Sci Rep. 2021 Jun 30;11(1):13553. (PMID: 34193899)
Lab Chip. 2018 Sep 26;18(19):2975-2984. (PMID: 30168832)
Am J Nephrol. 2021;52(2):98-107. (PMID: 33752206)
Biophys J. 2019 Jul 9;117(1):14-24. (PMID: 31235179)
Cells. 2021 Apr 02;10(4):. (PMID: 33918219)
Transfus Med Rev. 2011 Jan;25(1):24-35. (PMID: 21134624)
Lab Chip. 2015 Jan 7;15(1):159-67. (PMID: 25325848)
Biophys J. 2022 Jan 4;121(1):23-36. (PMID: 34896369)
Sci Rep. 2014 Mar 11;4:4348. (PMID: 24614613)
Med Eng Phys. 2016 Jan;38(1):17-23. (PMID: 26651215)
Transfusion. 2011 Apr;51(4):844-51. (PMID: 21496045)
Front Physiol. 2018 Jul 24;9:914. (PMID: 30087617)
Transfusion. 2006 Nov;46(11):2014-27. (PMID: 17076859)
Microcirculation. 2020 Oct;27(7):e12649. (PMID: 32663357)
Arch Surg. 2002 Jun;137(6):711-6; discussion 716-7. (PMID: 12049543)
Int J Mol Sci. 2021 May 17;22(10):. (PMID: 34067699)
PLoS Comput Biol. 2021 May 13;17(5):e1008934. (PMID: 33983926)
PLoS One. 2017 Feb 3;12(2):e0171371. (PMID: 28158274)
Front Physiol. 2019 Jul 31;10:945. (PMID: 31417415)
Cells. 2021 Sep 17;10(9):. (PMID: 34572104)
Microcirculation. 2016 Oct;23(7):479-486. (PMID: 27406436)
Transl Res. 2016 Jul;173:74-91.e8. (PMID: 27063958)
Blood Transfus. 2017 May;15(3):222-231. (PMID: 28518049)
Biomicrofluidics. 2010 Mar 15;4(2):. (PMID: 20697575)
J Neurol. 2005 Jan;252(1):84-90. (PMID: 15654559)
J Rheumatol. 1997 Nov;24(11):2263-5. (PMID: 9375897)
فهرسة مساهمة: Keywords: artificial capillary; erythrocyte; hemodiafiltration; microfluidics; neuroacanthocytosis syndrome; phase diagram; red cell storage; shape classification
تواريخ الأحداث: Date Created: 20220516 Latest Revision: 20231101
رمز التحديث: 20231101
مُعرف محوري في PubMed: PMC9091344
DOI: 10.3389/fphys.2022.884690
PMID: 35574449
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2022.884690