دورية أكاديمية
Ratanasampil is more effective than flunarizine in relieving migraine.
| العنوان: | Ratanasampil is more effective than flunarizine in relieving migraine. |
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| المؤلفون: | Zhu A; Institution of Geriatric, Qinghai Provincial People's Hospital, Xining, China., Zhong X; Institution of Geriatric, Qinghai Provincial People's Hospital, Xining, China., Zhu Y; Hospital Infection Management Office, Hospital of Xinjiang Production and Construction Corps, Urumqi, Xinjiang, China., Li P; Institution of Geriatric, Qinghai Provincial People's Hospital, Xining, China.; Department of Clinical Medicine, Medical School of Qinghai University, Xining, China., Zhang J; Institution of Geriatric, Qinghai Provincial People's Hospital, Xining, China., Hou Y; Institution of Geriatric, Qinghai Provincial People's Hospital, Xining, China., Song L; Institution of Geriatric, Qinghai Provincial People's Hospital, Xining, China.; Department of Radiotherapy, the 8th Medical Center of the Chinese PLA General Hospital, Beijing, China. |
| المصدر: | The International journal of neuroscience [Int J Neurosci] 2023 Dec; Vol. 133 (12), pp. 1326-1337. Date of Electronic Publication: 2022 May 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5279 (Electronic) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, Gordon and Breach. |
| مواضيع طبية MeSH: | Flunarizine*/therapeutic use , Migraine Disorders*/drug therapy , Migraine Disorders*/epidemiology, Humans ; Brain-Derived Neurotrophic Factor ; Serotonin ; Calcitonin Gene-Related Peptide/metabolism ; Calcitonin Gene-Related Peptide/therapeutic use ; Nerve Growth Factor ; Headache ; Biomarkers |
| مستخلص: | Aims: Migraine is a common neurological disorder with high incidence in population. This study aimed to investigate the therapeutic efficacy of Tibetan medicine Ratanasampil (RNSP) and to identify the serum biomarkers for diagnosis and response assessment. Materials and methods : We prospectively recruited 108 migraine patients living at high altitude (2,260 m), including 40 patients for RNSP group, 40 patients for flunarizine (FLZ) group, and 28 patients for placebo group. Serum levels of 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF), calcitonin gene related peptide (CGRP), nerve growth factor (NGF) and β-endorphin (β-EP) before and after therapy were measured. Results: In comparison with placebo, both FLZ and RNSP significantly reduced the migraine days, HIT-6 score and verbal rating scale, headache intensity, duration, accompanying symptoms and headache score in four and eight weeks treatment. RNSP showed no significant difference to FLZ in the above parameters after four weeks treatment, but showed significantly better relief after eight weeks treatment. The overall effective rate of RNSP (92.5%) was also significantly higher than FLZ (74.4%, p < 0.05), mainly due to significantly higher ratio of patients with full recovery. The serum levels of biomarkers, including 5-HT, BDNF, NGF and β-EP, significantly elevated after eight weeks of treatment with RNSP, whereas the level of CGRP significantly decreased. The serum level of 5-HT exhibited significantly bigger percentage changes than other markers. Conclusion: In conclusion, RNSP was more effective than FLZ in relieving migraine after eight weeks continuous treatment. Serum 5-HT, BDNF, CGRP, NGF and β-EP were effective markers reflecting the response to RNSP and FLZ therapy. |
| فهرسة مساهمة: | Keywords: 5-HT; CGRP; FLZ; Migraine; RNSP; Rannasangpei; flunarizine; headache |
| المشرفين على المادة: | R7PLA2DM0J (Flunarizine) 0 (Brain-Derived Neurotrophic Factor) 333DO1RDJY (Serotonin) JHB2QIZ69Z (Calcitonin Gene-Related Peptide) 9061-61-4 (Nerve Growth Factor) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20220518 Date Completed: 20231116 Latest Revision: 20231116 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/00207454.2022.2079503 |
| PMID: | 35583486 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1563-5279 |
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| DOI: | 10.1080/00207454.2022.2079503 |