دورية أكاديمية
أعرض في EDS

Prosaccade and Antisaccade Behavior in Fragile X-Associated Tremor/Ataxia Syndrome Progression.

التفاصيل البيبلوغرافية
العنوان: Prosaccade and Antisaccade Behavior in Fragile X-Associated Tremor/Ataxia Syndrome Progression.
المؤلفون: McLennan YA; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Pediatrics University of California Davis Medical Center Sacramento California USA., Mosconi MW; Life Span Institute, Kansas Center for Autism Research and Training, and Clinical Child Psychology Program University of Kansas Lawrence Kansas USA., McKenzie FJ; University of California Davis School of Medicine Sacramento California USA., Famula J; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Psychiatry and Behavioral Sciences University of California Davis Medical Center Sacramento California USA., Krawchuk B; University of California Davis School of Medicine Sacramento California USA., Kim K; Department of Psychology University of California Davis California USA., Clark CJ; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Pediatrics University of California Davis Medical Center Sacramento California USA., Hessl D; The MIND Institute University of California Davis Medical Center Sacramento California USA.; University of California Davis School of Medicine Sacramento California USA., Rivera SM; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Psychology University of California Davis California USA., Simon TJ; The MIND Institute University of California Davis Medical Center Sacramento California USA.; University of California Davis School of Medicine Sacramento California USA., Tassone F; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Biochemistry and Molecular Medicine University of California Davis School of Medicine Sacramento California USA., Hagerman RJ; The MIND Institute University of California Davis Medical Center Sacramento California USA.; Department of Pediatrics University of California Davis Medical Center Sacramento California USA.
المصدر: Movement disorders clinical practice [Mov Disord Clin Pract] 2022 Apr 28; Vol. 9 (4), pp. 473-478. Date of Electronic Publication: 2022 Apr 28 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101630279 Publication Model: eCollection Cited Medium: Internet ISSN: 2330-1619 (Electronic) Linking ISSN: 23301619 NLM ISO Abbreviation: Mov Disord Clin Pract Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, NJ : Wiley, [2014]-
مستخلص: Background: Quantitative measurement of eye movements can reveal subtle progression in neurodegenerative diseases.
Objective: To determine if quantitative measurements of eye movements may reveal subtle progression of fragile X-associated tremor and ataxia (FXTAS).
Methods: Prosaccade (PS) and antisaccade (AS) behavior was analyzed in 25 controls, 57 non-FXTAS carriers, and 46 carriers with FXTAS.
Results: Symptomatic individuals with FXTAS had longer AS latencies, increased rates of AS errors, and increased AS dysmetria relative to non-FXTAS carriers and controls. These deficits, along with PS latency and velocity, were greater in advanced FXTAS stages.
Conclusion: AS deficits differentiated FXTAS from non-FXTAS premutation carriers implicating top-down control and frontostriatal deterioration. However, the absence of group differences between non-FXTAS carriers and controls in AS and PS markers suggests saccade performance may not be a sensitive enough measure for detecting conversion to FXTAS, but instead more helpful as translational biomarkers of FXTAS progression.
(© 2022 International Parkinson and Movement Disorder Society.)
References: J Mol Diagn. 2008 Jan;10(1):43-9. (PMID: 18165273)
Biol Psychiatry. 2008 Apr 15;63(8):776-83. (PMID: 18191110)
Nat Rev Neurol. 2016 Jul;12(7):403-12. (PMID: 27340021)
Neuroimage Clin. 2020;27:102332. (PMID: 32711390)
Brain. 2015 Jul;138(Pt 7):1976-91. (PMID: 25895507)
J Am Acad Child Adolesc Psychiatry. 2009 Jul;48(7):749-756. (PMID: 19465877)
Cerebellum. 2016 Oct;15(5):636-40. (PMID: 27230899)
Prog Neurobiol. 2015 Sep;132:59-80. (PMID: 26159708)
Neurology. 2012 Jun 5;78(23):1824-31. (PMID: 22573640)
J Psychiatr Res. 2011 Jan;45(1):36-43. (PMID: 20537351)
J Neurophysiol. 1998 Oct;80(4):1911-31. (PMID: 9772249)
Neuropsychol Rev. 2018 Mar;28(1):16-31. (PMID: 29079970)
Front Neurol. 2010 Nov 22;1:138. (PMID: 21212841)
Neuropsychology. 2014 Jul;28(4):571-584. (PMID: 24773414)
J Clin Psychiatry. 2006 Jan;67(1):87-94. (PMID: 16426093)
Exp Brain Res. 1985;58(3):455-72. (PMID: 4007089)
Genes Brain Behav. 2012 Jul;11(5):577-85. (PMID: 22463693)
Am J Hum Genet. 2003 Apr;72(4):869-78. (PMID: 12638084)
J Psychiatr Res. 2013 Dec;47(12):1909-16. (PMID: 24045061)
PLoS One. 2014 Aug 14;9(8):e105355. (PMID: 25122508)
Neuroimage. 2014 Jul 15;95:61-8. (PMID: 24675647)
Clin Chem. 2010 Mar;56(3):399-408. (PMID: 20056738)
Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718):. (PMID: 28242726)
معلومات مُعتمدة: P50 HD103526 United States HD NICHD NIH HHS; R01 HD036071 United States HD NICHD NIH HHS; R01 MH078041 United States MH NIMH NIH HHS; R01 NS110100 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: FXTAS; antisaccade; eye movements; inhibitory deficits.; prosaccade
تواريخ الأحداث: Date Created: 20220519 Latest Revision: 20240526
رمز التحديث: 20240526
مُعرف محوري في PubMed: PMC9092736
DOI: 10.1002/mdc3.13449
PMID: 35586536
قاعدة البيانات: MEDLINE
الوصف
تدمد:2330-1619
DOI:10.1002/mdc3.13449