دورية أكاديمية
Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center.
| العنوان: | Prevalence of Intracranial Aneurysms in Hereditary Hemorrhagic Telangiectasia: Report from a Single Reference Center. |
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| المؤلفون: | Perez Akly MS; From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina sliman.perez@hospitalitaliano.org.ar.; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina., Vazquez C; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; Department of Internal Medicine (C.V., M.M.S.), Hospital Italiano, Buenos Aires, Argentina., Besada CH; From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina., Rodriguez MJ; From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Conde MF; From the Department of Radiology (M.S.P.A., C.H.B., M.J.R., C.M.F.), Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Cajal AR; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina.; Translational Medicine and Biomedical Engineering Institute (A.R.C.), Buenos Aires, Argentina.; University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina., Peuchot VA; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; Internal Medicine Research Area (V.A.P.), Hospital Italiano, Buenos Aires, Argentina., Dardik D; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; From the Department of Radiology (D.D.), Clínica Instituto de Diagnóstico Sociedad Anónima (INDISA), Santiago, Chile., Baccanelli MM; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; Department of Neurosurgery (M.M.B.), Hospital Italiano, Buenos Aires, Argentina.; Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina.; University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina., Serra MM; A.R.G. Argentine Rendu Study Group (M.S.P.A., C.V., C.H.B., A.R.C., VA.P., D.D., M.M.B., M.M.S.), Buenos Aires, Argentina.; Department of Internal Medicine (C.V., M.M.S.), Hospital Italiano, Buenos Aires, Argentina.; Hereditary Hemorrhagic Telangiectasia Unit (M.S.P.A., C.H.B., A.R.C., M.M.B., M.M.S.) Hospital Italiano, Buenos Aires, Argentina.; University Institute (A.R.C., M.M.B., M.M.S.), Hospital Italiano, Buenos Aires, Argentina. |
| المصدر: | AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2022 Jun; Vol. 43 (6), pp. 844-849. Date of Electronic Publication: 2022 May 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Neuroradiology Country of Publication: United States NLM ID: 8003708 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-959X (Electronic) Linking ISSN: 01956108 NLM ISO Abbreviation: AJNR Am J Neuroradiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oak Brook, IL : American Society of Neuroradiology Original Publication: Baltimore, Williams & Wilkins. |
| مواضيع طبية MeSH: | Central Nervous System Vascular Malformations*/complications , Embolization, Therapeutic* , Intracranial Aneurysm*/complications , Intracranial Aneurysm*/diagnostic imaging , Intracranial Aneurysm*/epidemiology , Telangiectasia, Hereditary Hemorrhagic*/complications , Telangiectasia, Hereditary Hemorrhagic*/diagnostic imaging , Telangiectasia, Hereditary Hemorrhagic*/epidemiology, Adult ; Humans ; Prevalence ; Retrospective Studies |
| مستخلص: | Background and Purpose: Neurologic manifestations in hereditary hemorrhagic telangiectasia include an increased incidence of brain abscesses and ischemic strokes due to paradoxic embolization in addition to a wide spectrum of symptoms and complications due to typical brain vascular malformations. Intracranial aneurysms are not part of this brain vascular malformation spectrum. The aim of this study was to determine their prevalence in patients with hereditary hemorrhagic telangiectasia. Materials and Methods: This was a single-center, retrospective study. Adult patients from the institutional Hereditary Hemorrhagic Telangiectasia registry with a definitive diagnosis of hereditary hemorrhagic telangiectasia and an available report or angiographic imaging study were included and reviewed to determine the intracranial aneurysm prevalence. In addition, the morphologic characteristics of intracranial aneurysms and possible associated risk factors were collected. Results: Two hundred twenty-eight patients were analyzed. Thirty-seven aneurysms in 33 patients (14.5%; 95% CI, 9.9%-19%) were found. The median diameter of intracranial aneurysms was 3.2 mm (interquartile range, 2.6-4.4 mm). No association between intracranial aneurysm and sex, age, or genetic background was noted. There were no subarachnoid hemorrhagic events due to intracranial aneurysm rupture. Conclusions: Due to the high prevalence of intracranial aneurysms in adult patients with hereditary hemorrhagic telangiectasia, further studies regarding bleeding risks and monitoring should be addressed. (© 2022 by American Journal of Neuroradiology.) |
| References: | J Neurosurg. 2014 Jan;120(1):87-92. (PMID: 24236651) Front Genet. 2015 Jan 26;6:1. (PMID: 25674101) Eur J Hum Genet. 2009 Jul;17(7):860-71. (PMID: 19337313) J Neurosurg. 2017 Aug;127(2):302-310. (PMID: 27767404) Neurol Med Chir (Tokyo). 2012;52(7):502-5. (PMID: 22850500) Intern Emerg Med. 2012 Aug;7(4):385-6. (PMID: 22782335) J Med Life. 2015 Jul-Sep;8(3):336-41. (PMID: 26351537) Ann Intern Med. 2020 Dec 15;173(12):989-1001. (PMID: 32894695) Nat Med. 2010 Apr;16(4):420-8. (PMID: 20364125) Neurosurgery. 2018 Jan 1;82(1):35-47. (PMID: 28973426) Nervenarzt. 1995 Feb;66(2):124-8. (PMID: 7715751) Lancet Neurol. 2014 Jan;13(1):59-66. (PMID: 24290159) Neuroradiology. 2005 Oct;47(10):711-20. (PMID: 16136265) AJNR Am J Neuroradiol. 1984 Sep-Oct;5(5):569-73. (PMID: 6435422) Stroke. 2001 Apr;32(4):877-82. (PMID: 11283386) Blood Rev. 2010 Nov;24(6):203-19. (PMID: 20870325) J Med Genet. 2011 Feb;48(2):73-87. (PMID: 19553198) J Vasc Interv Radiol. 2021 Dec;32(12):1661-1669. (PMID: 34478850) Lancet Neurol. 2011 Jul;10(7):626-36. (PMID: 21641282) Am J Surg Pathol. 2009 Feb;33(2):194-201. (PMID: 18852674) J Neurosurg. 1990 Dec;73(6):859-63. (PMID: 2230969) Dis Mon. 2011 Oct;57(10):647-55. (PMID: 22036120) AJNR Am J Neuroradiol. 1998 Mar;19(3):477-84. (PMID: 9541302) Int J Cardiol. 2017 Oct 15;245:114-118. (PMID: 28874282) Laryngoscope Investig Otolaryngol. 2021 Apr 08;6(3):370-375. (PMID: 34195356) Arch Fr Pediatr. 1990 Dec;47(10):741-2. (PMID: 2082850) Interv Neuroradiol. 2016 Dec;22(6):624-637. (PMID: 27511817) Surg Neurol. 1973 Mar;1(2):91-3. (PMID: 4772800) AJNR Am J Neuroradiol. 2016 Aug;37(8):1422-6. (PMID: 26992822) Front Genet. 2015 Mar 23;6:114. (PMID: 25852751) No Shinkei Geka. 1981 Jan;9(1):67-72. (PMID: 7231629) Int J Mol Sci. 2019 Jun 25;20(12):. (PMID: 31242676) Int J Cardiol. 2017 Oct 15;245:145-146. (PMID: 28874286) Stroke. 1983 May-Jun;14(3):419-21. (PMID: 6658911) J Med Genet. 2006 Feb;43(2):97-110. (PMID: 15879500) Acta Neurochir (Wien). 2016 Nov;158(11):2095-2104. (PMID: 27644700) Stroke. 2013 Dec;44(12):3613-22. (PMID: 24130141) Thorax. 1999 Aug;54(8):714-29. (PMID: 10413726) J Clin Med. 2020 Nov 05;9(11):. (PMID: 33167572) Neurosurgery. 2012 Mar;70(3):693-9; discussion 699-701. (PMID: 21904261) J Neurosurg. 2008 Jun;108(6):1132-8. (PMID: 18518716) AJNR Am J Neuroradiol. 2016 Nov;37(11):1966-1971. (PMID: 27339951) Ann Neurol. 1978 Aug;4(2):130-44. (PMID: 707984) Neurology. 2019 Jan 1;92(1):34-42. (PMID: 30584075) Orphanet J Rare Dis. 2017 May 18;12(1):92. (PMID: 28521822) AJNR Am J Neuroradiol. 2016 Aug;37(8):1479-86. (PMID: 27012295) Eur J Radiol. 2013 Oct;82(10):1598-605. (PMID: 23399038) J Neurosurg. 2000 May;92(5):779-84. (PMID: 10794291) |
| تواريخ الأحداث: | Date Created: 20220519 Date Completed: 20220609 Latest Revision: 20230602 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC9172960 |
| DOI: | 10.3174/ajnr.A7505 |
| PMID: | 35589139 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1936-959X |
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| DOI: | 10.3174/ajnr.A7505 |