دورية أكاديمية
أعرض في EDS

Site-Specific Regulation of Sulfatase and Aromatase Pathways for Estrogen Production in Endometriosis.

التفاصيل البيبلوغرافية
العنوان: Site-Specific Regulation of Sulfatase and Aromatase Pathways for Estrogen Production in Endometriosis.
المؤلفون: Da Costa KA; Hospital Israelita Albert Einstein, São Paulo, Brazil., Malvezzi H; Hospital Israelita Albert Einstein, São Paulo, Brazil., Dobo C; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Department of Clinical Pathology, Hospital Israelita Albert Einstein, São Paulo, Brazil., Neme RM; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Centro de Endometriose São Paulo, Av. República Do Líbano, São Paulo, Brazil., Filippi RZ; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Department of Clinical Pathology, Hospital Israelita Albert Einstein, São Paulo, Brazil., Aloia TPA; Hospital Israelita Albert Einstein, São Paulo, Brazil., Prado ER; Hospital Israelita Albert Einstein, São Paulo, Brazil., Meola J; Department of Gynaecology & Obstetrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil., Piccinato CA; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Department of Gynaecology & Obstetrics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
المصدر: Frontiers in molecular biosciences [Front Mol Biosci] 2022 May 03; Vol. 9, pp. 854991. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653173 Publication Model: eCollection Cited Medium: Print ISSN: 2296-889X (Print) Linking ISSN: 2296889X NLM ISO Abbreviation: Front Mol Biosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Endometriosis is a highly prevalent gynecological disease characterized by lesions in different sites. Regulation of specific estrogen pathways may favor the formation of distinct microenvironments and the progression of endometriosis. However, no study has simultaneously evaluated the gene and protein regulation of the main estrogen-synthesizing enzymes in endometriosis. Thus, our goals were to study the relationship between gene and protein expression of aromatase ( CYP19A1 or ARO), steroid sulfatase (STS), and hydroxysteroid 17-beta dehydrogenase (HSD17B1) in superficial (SUP), ovarian (OMA), and deep infiltrating (DIE) endometriotic lesion sites as well as in the eutopic endometrium of patients with (EE) and without (control) endometriosis in the same and large cohort of patients. The site-specific expression of these enzymes within different cells (glandular and stromal components) was also explored. The study included 108 patients surgically diagnosed with endometriosis who provided biopsies of EE and endometriotic lesions and 16 disease-free patients who collected normal endometrium tissue. Our results showed that CYP19A1 was detected in all endometriosis tissues and was in higher levels than in control. Unique patterns of the STS and HSD17B1 levels showed that they were most closely regulated in all tissues, with manifestation at greater levels in DIE compared to the other endometriotic lesion sites, OMA and SUP. Gene and protein expression of ARO, STS, and HSD17B1 occurred at different rates in endometriotic sites or EE. The distinctive levels of these estrogen-synthesizing enzymes in each endometriotic site support the hypothesis of a tissue microenvironment that can both influence and be influenced by the expression of different estrogenic pathways, locally affecting the availability of estrogen needed for maintenance and progression of endometriotic lesions.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Da Costa, Malvezzi, Dobo, Neme, Filippi, Aloia, Prado, Meola and Piccinato.)
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فهرسة مساهمة: Keywords: CYP19A1; HSD17B1; STS; aromatase; endometrium; estradiol; glandular cells; stromal cells
تواريخ الأحداث: Date Created: 20220520 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9110888
DOI: 10.3389/fmolb.2022.854991
PMID: 35591944
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-889X
DOI:10.3389/fmolb.2022.854991