دورية أكاديمية
A new approach against Helicobacter pylori using plants and its constituents: A review study.
| العنوان: | A new approach against Helicobacter pylori using plants and its constituents: A review study. |
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| المؤلفون: | Sathianarayanan S; Faculty of Pharmacy, Karpagam Academy of Higher Education, Salem-Kochi Highway, Eachanari, Coimbatore, India. Electronic address: ssnvij@yahoo.co.in., Ammanath AV; Centre for Nano Sciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus, Kochi, 682041, Kerala, India; Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tubingen (IMIT) University of Tubingen, Tubingen, Germany., Biswas R; Centre for Nano Sciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus, Kochi, 682041, Kerala, India. Electronic address: rajabiswas@aims.amrita.edu., B A; Amrita School of Pharmacy, AIMS Ponekkara, Kochi, India., Sukumaran S; Nirmala College of Pharmacy, Muvattupzha, Kerala, India., Venkidasamy B; University Center for Research & Development, Chandigarh University, Chandigarh, India. Electronic address: baskarbt07@gmail.com. |
| المصدر: | Microbial pathogenesis [Microb Pathog] 2022 Jul; Vol. 168, pp. 105594. Date of Electronic Publication: 2022 May 21. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London ; Orlando : Academic Press, c1986- |
| مواضيع طبية MeSH: | Glycyrrhiza* , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Helicobacter pylori* , Plants, Medicinal*/chemistry, Anti-Bacterial Agents/chemistry ; Humans ; Plant Extracts/chemistry |
| مستخلص: | Helicobacter pylori is a Gram-negative, spiral-shaped bacillus that colonizes 50% of the world population and is considered a class 1 carcinogen by the World Health Organization. This pathogen is the most common cause of infection-related cancers. Apart from cancer, it also causes several gastric and extra gastric diseases. Eradication of H. pylori using antibiotics is a global challenge because of its drug resistance. Alternative treatment options are gaining more attention to tackle drug-resistant H. pylori infections. Several medicinal plants and their isolated compounds have been reported for their antimicrobial activity against H. pylori. The mechanism of action of many of these plant extracts and plant-derived compounds is different from that of conventional antibiotics. Therefore they are shown to be effective against drug-resistant strains of H. pylori. They act by inhibiting bacterial enzymes, adhesions with gastric mucosa, suppression of nuclear factor-κB and by inhibition of oxidative stress. Extracts from Pistacia lentiscus, Brassica oleracea, Glycyrrhiza glabra, Camellia sinensis, Cinnamomum cassia, Allium sativum and Nigella sativa plants and isolated phyto-compounds such as curcumin, resveratrol, quercetin, allicin and ellagic acid demonstrated antimicrobial activity against H. pylori under in vivo conditions. The plant extracts of Zingiber officinale, Glycyrrhiza glabra; and phytochemical allicin and berberine when combined with standard treatment, result in a dramatic increase in H. pylori eradication. In this review, we highlighted the therapeutic efficacy of different plant extracts and isolated phyto compounds against H. pylori infection and described their role in tackling H. pylori resistance to antibiotics. (Copyright © 2022 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Drug resistance; H pylori; Plants/phyto compounds; Proinflammatory factor; Virulence factors |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20220523 Date Completed: 20220617 Latest Revision: 20220617 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.micpath.2022.105594 |
| PMID: | 35605740 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-1208 |
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| DOI: | 10.1016/j.micpath.2022.105594 |