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Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs.

التفاصيل البيبلوغرافية
العنوان: Polymicrobial infections can select against Pseudomonas aeruginosa mutators because of quorum-sensing trade-offs.
المؤلفون: Luján AM; ESI and CEC, Biosciences, University of Exeter, Penryn, UK. adem.lujan@gmail.com.; Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina. adem.lujan@gmail.com.; Centro de Investigaciones en Química Biológica de Córdoba, CONICET, Córdoba, Argentina. adem.lujan@gmail.com.; Instituto de Investigaciones en Recursos Naturales y Sustentabilidad Jose Sanchez Labrador S.J., IRNASUS-CONICET, Córdoba, Argentina. adem.lujan@gmail.com., Paterson S; Institute of Integrative Biology, University of Liverpool, Liverpool, UK., Hesse E; ESI and CEC, Biosciences, University of Exeter, Penryn, UK., Sommer LM; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark., Marvig RL; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.; Center for Genomic Medicine, Rigshopitalet, Copenhagen, Denmark., Sharma MD; ESI and CEC, Biosciences, University of Exeter, Penryn, UK., Alseth EO; ESI and CEC, Biosciences, University of Exeter, Penryn, UK., Ciofu O; Costerton Biofilm Center, Department for Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Smania AM; Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina.; Centro de Investigaciones en Química Biológica de Córdoba, CONICET, Córdoba, Argentina., Molin S; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark., Johansen HK; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.; Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Buckling A; ESI and CEC, Biosciences, University of Exeter, Penryn, UK.
المصدر: Nature ecology & evolution [Nat Ecol Evol] 2022 Jul; Vol. 6 (7), pp. 979-988. Date of Electronic Publication: 2022 May 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101698577 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-334X (Electronic) Linking ISSN: 2397334X NLM ISO Abbreviation: Nat Ecol Evol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Springer Nature
مواضيع طبية MeSH: Coinfection*/complications , Cystic Fibrosis*/complications , Cystic Fibrosis*/microbiology , Pseudomonas Infections*/complications , Pseudomonas Infections*/microbiology, Humans ; Pseudomonas aeruginosa/genetics ; Quorum Sensing
مستخلص: Bacteria with increased mutation rates (mutators) are common in chronic infections and are associated with poorer clinical outcomes, especially in the case of Pseudomonas aeruginosa infecting cystic fibrosis (CF) patients. There is, however, considerable between-patient variation in both P. aeruginosa mutator frequency and the composition of co-infecting pathogen communities. We investigated whether community context might affect selection of mutators. Using an in vitro CF model community, we show that P. aeruginosa mutators were favoured in the absence of other species but not in their presence. This was because there were trade-offs between adaptation to the biotic and abiotic environments (for example, loss of quorum sensing and associated toxin production was beneficial in the latter but not the former in our in vitro model community) limiting the evolvability advantage of an elevated mutation rate. Consistent with a role of co-infecting pathogens selecting against P. aeruginosa mutators in vivo, we show that the mutation frequency of P. aeruginosa population was negatively correlated with the frequency and diversity of co-infecting bacteria in CF infections. Our results suggest that co-infecting taxa can select against P. aeruginosa mutators, which may have potentially beneficial clinical consequences.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
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معلومات مُعتمدة: MR/V022482/1 United Kingdom MRC_ Medical Research Council
سلسلة جزيئية: figshare 10.6084/m9.figshare.13739452
تواريخ الأحداث: Date Created: 20220526 Date Completed: 20220711 Latest Revision: 20221020
رمز التحديث: 20221213
DOI: 10.1038/s41559-022-01768-1
PMID: 35618819
قاعدة البيانات: MEDLINE
الوصف
تدمد:2397-334X
DOI:10.1038/s41559-022-01768-1