دورية أكاديمية
أعرض في EDS

Approaches to Configuration Determinations of Flexible Marine Natural Products: Advances and Prospects.

التفاصيل البيبلوغرافية
العنوان: Approaches to Configuration Determinations of Flexible Marine Natural Products: Advances and Prospects.
المؤلفون: Huo ZQ; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China., Zhu F; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China., Zhang XW; State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China., Zhang X; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Liang HB; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China.; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Yao JC; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China., Liu Z; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China., Zhang GM; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China.; College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China., Yao QQ; Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China., Qin GF; State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine, Lunan Pharmaceutical Group Co., Ltd., Linyi 273400, China.
المصدر: Marine drugs [Mar Drugs] 2022 May 19; Vol. 20 (5). Date of Electronic Publication: 2022 May 19.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Biological Products*/chemistry, Circular Dichroism ; Crystallography, X-Ray ; Magnetic Resonance Spectroscopy ; Molecular Structure
مستخلص: Flexible marine natural products (MNPs), such as eribulin and bryostatin, play an important role in the development of modern marine drugs. However, due to the multiple chiral centers and geometrical uncertainty of flexible systems, configuration determinations of flexible MNPs face great challenges, which, in turn, have led to obstacles in druggability research. To resolve this issue, the comprehensive use of multiple methods is necessary. Additionally, configuration assignment methods, such as X-ray single-crystal diffraction (crystalline derivatives, crystallization chaperones, and crystalline sponges), NMR-based methods (JBCA and Mosher's method), circular dichroism-based methods (ECCD and ICD), quantum computational chemistry-based methods (NMR calculations, ECD calculations, and VCD calculations), and chemical transformation-based methods should be summarized. This paper reviews the basic principles, characteristics, and applicability of the methods mentioned above as well as application examples to broaden the research and applications of these methods and to provide a reference for the configuration determinations of flexible MNPs.
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معلومات مُعتمدة: 32000039 National Natural Science Foundation of China; 2021CXGC010508 Shandong Provincial Key Research and Development Program (Major Technological Innovation Project); 2019ZDZX001 Independent Innovation Major Project of Linyi City, Shandong Province
فهرسة مساهمة: Keywords: NMR-based methods; X-ray single-crystal diffraction; chemical transformation-based methods; circular dichroism-based methods; configuration determinations; flexible marine natural products; quantum computational chemistry-based methods
المشرفين على المادة: 0 (Biological Products)
تواريخ الأحداث: Date Created: 20220527 Date Completed: 20220531 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9143581
DOI: 10.3390/md20050333
PMID: 35621984
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md20050333