دورية أكاديمية
أعرض في EDS

Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed.

التفاصيل البيبلوغرافية
العنوان: Capturing Genetic Diversity and Selection Signatures of the Endangered Kosovar Balusha Sheep Breed.
المؤلفون: Adeniyi OO; Institute of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany., Simon R; Institute of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany., Bytyqi H; Faculty of Agriculture and Veterinary, University of Pristina, 10000 Pristina, Kosovo., Kugler W; SAVE Foundation, 9000 St. Gallen, Switzerland., Mehmeti H; Faculty of Agriculture and Veterinary, University of Pristina, 10000 Pristina, Kosovo., Berisha K; Faculty of Agriculture and Veterinary, University of Pristina, 10000 Pristina, Kosovo., Simčič M; Department of Animal Science, Biotechnical Faculty, University of Ljubljana, SI-1000 Ljubljana, Slovenia., Magdy M; Institute of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany., Lühken G; Institute of Animal Breeding and Genetics, Justus Liebig University, 35390 Giessen, Germany.
المصدر: Genes [Genes (Basel)] 2022 May 12; Vol. 13 (5). Date of Electronic Publication: 2022 May 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Breeding* , Inbreeding*, Animals ; Genotype ; Homozygote ; Humans ; Polymorphism, Single Nucleotide/genetics ; Sheep/genetics
مستخلص: There is a growing concern about the loss of animal genetic resources. The aim of this study was to analyze the genetic diversity and potential peculiarity of the endangered Kosovar sheep breed Balusha. For this purpose, a dataset consisting of medium-density SNP chip genotypes (39,879 SNPs) from 45 Balusha sheep was generated and compared with SNP chip genotypes from 29 individuals of a second Kosovar breed, Bardhoka. Publicly available SNP genotypes from 39 individuals of the relatively closely located sheep breeds Istrian Pramenka and Ruda were additionally included in the analyses. Analysis of heterozygosity, allelic richness and effective population size was used to assess the genetic diversity. Inbreeding was evaluated using two different methods ( F IS , F ROH ). The standardized F ST ( d i ) and cross-population extended haplotype homozygosity (XPEHH) methods were used to detect signatures of selection. We observed the lowest heterozygosity ( H O = 0.351) and effective population size (Ne 5 = 25, Ne 50 = 228) for the Balusha breed. The mean allelic richness levels (1.780-1.876) across all analyzed breeds were similar and also comparable with those in worldwide breeds. F ROH estimates (0.023-0.077) were highest for the Balusha population, although evidence of decreased inbreeding was observed in F IS results for the Balusha breed. Two Gene Ontology (GO) TERMs were strongly enriched for Balusha, and involved genes belonging to the melanogenesis and T cell receptor signaling pathways, respectively. This could result from selection for the special coat color pattern of Balusha (black head) and resistance to certain infectious diseases. The analyzed diversity parameters highlight the urgency to preserve the local Kosovar Balusha sheep as it is clearly distinguished from other sheep of Southeastern Europe, has the lowest diversity level and may harbor valuable genetic variants, e.g., for resistance to infectious diseases.
References: BMC Genomics. 2020 Jan 29;21(1):94. (PMID: 31996125)
Genet Sel Evol. 2020 May 14;52(1):25. (PMID: 32408891)
Comp Immunol Microbiol Infect Dis. 2011 May;34(3):197-208. (PMID: 21216466)
Endocrinology. 2004 Dec;145(12):5459-64. (PMID: 15331575)
J Anim Breed Genet. 2012 Aug;129(4):257-70. (PMID: 22775258)
Front Genet. 2017 Dec 22;8:218. (PMID: 29312441)
PLoS One. 2009;4(3):e4668. (PMID: 19270757)
Curr Protoc Hum Genet. 2011 Oct;Chapter 18:Unit18.6. (PMID: 21975940)
Theor Popul Biol. 1973 Mar;4(1):129-32. (PMID: 4726005)
Anim Genet. 2019 Oct;50(5):512-525. (PMID: 31365135)
Genetics. 2011 Sep;189(1):237-49. (PMID: 21705750)
Nat Rev Immunol. 2011 Nov 25;11(12):852-63. (PMID: 22116087)
Mol Cell Biochem. 2021 Mar;476(3):1401-1409. (PMID: 33389492)
Anim Genet. 2016 Dec;47(6):727-739. (PMID: 27436146)
Dev Cell. 2009 Jul;17(1):9-26. (PMID: 19619488)
Ann Hum Genet. 1983 Jul;47(3):253-9. (PMID: 6614868)
Arch Anim Breed. 2019 Jul 10;62(2):393-402. (PMID: 31807650)
Biochem J. 1996 Feb 15;314 ( Pt 1):305-12. (PMID: 8660299)
PLoS One. 2017 May 2;12(5):e0176780. (PMID: 28463982)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Bioinformatics. 2008 Nov 1;24(21):2498-504. (PMID: 18779233)
Am J Hum Genet. 2008 Sep;83(3):359-72. (PMID: 18760389)
Am J Respir Crit Care Med. 2008 Jul 15;178(2):203-7. (PMID: 18420963)
Anim Genet. 2019 Jun;50(3):298-302. (PMID: 30883840)
Gigascience. 2015 Feb 25;4:7. (PMID: 25722852)
Front Immunol. 2016 Aug 10;7:304. (PMID: 27559335)
Annu Rev Immunol. 2009;27:591-619. (PMID: 19132916)
Genet Sel Evol. 2015 Nov 24;47:90. (PMID: 26602211)
Nature. 2007 Oct 18;449(7164):913-8. (PMID: 17943131)
Animal. 2017 Jul;11(7):1107-1116. (PMID: 28077191)
Anim Genet. 2007 Feb;38(1):37-44. (PMID: 17257186)
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1160-5. (PMID: 20080661)
PLoS Biol. 2006 Mar;4(3):e72. (PMID: 16494531)
Anim Genet. 2020 Mar;51(2):258-265. (PMID: 31881555)
J Anim Sci. 1999 Jan;77(1):61-9. (PMID: 10064028)
J Endocrinol. 2008 Feb;196(2):193-214. (PMID: 18252944)
J Cutan Med Surg. 2008 Mar-Apr;12(2):64-70. (PMID: 18346402)
J Anim Breed Genet. 2021 Sep;138(5):574-588. (PMID: 33453096)
Am J Hum Genet. 2006 Apr;78(4):629-44. (PMID: 16532393)
J Anim Breed Genet. 2008 Dec;125(6):417-26. (PMID: 19134078)
Genet Sel Evol. 2018 May 24;50(1):29. (PMID: 29793424)
Mol Ecol. 2008 Jan;17(1):275-84. (PMID: 17927711)
Front Genet. 2019 Dec 12;10:1311. (PMID: 31921318)
Mol Ecol Resour. 2017 Jan;17(1):27-32. (PMID: 26850166)
PLoS Biol. 2012 Feb;10(2):e1001258. (PMID: 22346734)
Anim Genet. 2018 Feb;49(1):71-81. (PMID: 29333609)
Pigment Cell Melanoma Res. 2010 Apr;23(2):160-70. (PMID: 20128875)
J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S33-40. (PMID: 20061006)
Nucleic Acids Res. 2009 Jan;37(1):1-13. (PMID: 19033363)
Mol Ecol. 2011 Aug;20(15):3128-43. (PMID: 21689193)
Trends Pharmacol Sci. 1992 Mar;13(3):103-8. (PMID: 1315462)
Int J Tuberc Lung Dis. 2013 Sep;17(9):1224-8. (PMID: 23827504)
Sci Rep. 2021 Feb 2;11(1):2834. (PMID: 33531649)
Science. 2009 Apr 24;324(5926):532-6. (PMID: 19390051)
Anim Genet. 2010 May;41 Suppl 1:6-31. (PMID: 20500753)
Genome Res. 2009 Sep;19(9):1655-64. (PMID: 19648217)
Evolution. 1984 Nov;38(6):1358-1370. (PMID: 28563791)
Int J Mol Sci. 2016 Jul 15;17(7):. (PMID: 27428965)
Animals (Basel). 2019 Sep 15;9(9):. (PMID: 31540148)
Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173)
Immunotargets Ther. 2015 May 28;4:111-22. (PMID: 27471717)
Immunity. 2018 Feb 20;48(2):202-213. (PMID: 29466753)
Theriogenology. 2000 Jan 1;53(1):149-62. (PMID: 10735070)
Bioinformatics. 2010 Nov 15;26(22):2867-73. (PMID: 20926424)
Development. 2009 Oct;136(19):3205-14. (PMID: 19736321)
Eur J Hum Genet. 2011 Jun;19(6):676-81. (PMID: 21368909)
Front Genet. 2015 Mar 20;6:109. (PMID: 25852748)
فهرسة مساهمة: Keywords: Balkan; GO TERMS; Pramenka; ROH; conservation/preservation; ovis aries; population structure
تواريخ الأحداث: Date Created: 20220528 Date Completed: 20220531 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9140571
DOI: 10.3390/genes13050866
PMID: 35627251
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes13050866