دورية أكاديمية
أعرض في EDS

Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors.

التفاصيل البيبلوغرافية
العنوان: Curcumin Protects Diabetic Mice against Isoproterenol-Induced Myocardial Infarction by Modulating CB2 Cannabinoid Receptors.
المؤلفون: Pawar HD; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, India., Mahajan UB; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, India., Nakhate KT; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, India., Agrawal YO; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, India., Patil CR; Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, India., Meeran MFN; Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Sharma C; Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Ojha S; Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.; Zayed Bin Sultan Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates., Goyal SN; Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, India.
المصدر: Life (Basel, Switzerland) [Life (Basel)] 2022 Apr 22; Vol. 12 (5). Date of Electronic Publication: 2022 Apr 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101580444 Publication Model: Electronic Cited Medium: Print ISSN: 2075-1729 (Print) Linking ISSN: 20751729 NLM ISO Abbreviation: Life (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Molecular docking revealed curcumin as a potent CB2 cannabinoid receptor (CB2R) agonist. Since CB2R is involved in cardioprotective functions, we explored its role in ameliorative actions of curcumin against myocardial damage triggered by isoproterenol in diabetic animals. Mice were kept on a high-fat diet (HFD) throughout the experiment (30 days). Following 7 days of HFD feeding, streptozotocin was administered (150 mg/kg, intraperitoneal) to induce diabetes. From day 11 to 30, diabetic mice received either curcumin (100 or 200 mg/kg/day, oral), CB2R antagonist AM630 (1 mg/kg/day, intraperitoneal) or both, with concurrent isoproterenol (150 mg/kg, subcutaneous) administration on day 28 and 29. Diabetic mice with myocardial infarction showed an altered hemodynamic pattern and lipid profile, reduced injury markers, antioxidants with increased lipid peroxidation in the myocardium, and elevated glucose and liver enzymes in the blood. Moreover, an increased pro-inflammatory markers, histological severity, myonecrosis, and edema were observed. Curcumin compensated for hemodynamic fluctuations, restored biochemical markers, preserved antioxidant capacity, decreased cytokines levels, and restored cardiac functionality. However, the AM630 pre-treatment attenuated the effects of curcumin. The data suggest the involvement of CB2R in the actions of curcumin such as in the prevention of myocardial stress and in the improvement of the normal status of the myocardial membrane associated with diabetes.
References: Circ Res. 2005 May 13;96(9):939-49. (PMID: 15890981)
Chem Biol Interact. 2016 Jan 25;244:49-63. (PMID: 26656244)
Nature. 2000 Apr 13;404(6779):787-90. (PMID: 10783895)
J Diabetes Metab Disord. 2021 Feb 03;20(1):119-130. (PMID: 34222062)
Cell Physiol Biochem. 2013;31(4-5):693-702. (PMID: 23711495)
Molecules. 2019 Aug 01;24(15):. (PMID: 31374848)
Exp Ther Med. 2018 Dec;16(6):4900-4908. (PMID: 30542446)
Antioxidants (Basel). 2018 Jul 18;7(7):. (PMID: 30021985)
Diabetes Ther. 2016 Jun;7(2):175-85. (PMID: 27010644)
F1000Res. 2018 Sep 3;7:. (PMID: 30228871)
Mol Pharmacol. 2014 Oct;86(4):430-7. (PMID: 25106425)
Pharmacol Res. 2005 Oct;52(4):313-20. (PMID: 15979893)
Mol Cell Biochem. 2019 Jun;456(1-2):105-113. (PMID: 30652241)
Am J Manag Care. 2018 Aug;24(13 Suppl):S268-S272. (PMID: 30160393)
Appl Physiol Nutr Metab. 2020 Jan;45(1):24-34. (PMID: 31084576)
Biomed Pharmacother. 2018 May;101:379-390. (PMID: 29501041)
Biosci Rep. 2019 Apr 26;39(4):. (PMID: 30923227)
J Diabetes Metab Disord. 2021 Feb 05;20(1):341-348. (PMID: 34178842)
Oxid Med Cell Longev. 2017;2017:2186383. (PMID: 28814985)
Indian J Pharmacol. 2012 Jan;44(1):73-7. (PMID: 22345874)
J Diabetes Res. 2018 Sep 23;2018:8054073. (PMID: 30345315)
Foods. 2017 Oct 22;6(10):. (PMID: 29065496)
Int J Mol Sci. 2020 Apr 15;21(8):. (PMID: 32326655)
Atherosclerosis. 2014 Jan;232(1):40-51. (PMID: 24401215)
Hum Exp Toxicol. 2014 Aug;33(8):800-13. (PMID: 24648241)
Neurochem Res. 2012 May;37(5):1112-20. (PMID: 22311129)
J Leukoc Biol. 2004 Mar;75(3):453-9. (PMID: 14657208)
Adv Exp Med Biol. 2021;1308:37-44. (PMID: 33861435)
Compr Physiol. 2015 Sep 20;5(4):1841-75. (PMID: 26426469)
AAPS J. 2010 Jun;12(2):233-7. (PMID: 20204561)
Brain Res. 2016 Sep 1;1646:1-11. (PMID: 27208493)
Nat Rev Cardiol. 2018 Mar;15(3):151-166. (PMID: 28905873)
Eur J Pharmacol. 2019 Nov 5;862:172628. (PMID: 31461639)
Evid Based Complement Alternat Med. 2015;2015:238482. (PMID: 26664449)
Arch Physiol Biochem. 2019 Jul;125(3):210-219. (PMID: 29519157)
Int J Mol Sci. 2017 Apr 04;18(4):. (PMID: 28375162)
Eur J Pharmacol. 2021 Dec 15;913:174645. (PMID: 34800467)
Exp Ther Med. 2019 Mar;17(3):2185-2193. (PMID: 30867704)
Int J Mol Sci. 2015 Nov 17;16(11):27457-69. (PMID: 26593900)
معلومات مُعتمدة: EMR/2016/005106 Science and Engineering Research Board; University Program for Advanced Research (UPAR) United Arab Emirates University
فهرسة مساهمة: Keywords: CB2 receptor; curcumin; diabetes; myocardial infarction; oxidative stress
تواريخ الأحداث: Date Created: 20220528 Latest Revision: 20220716
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9143027
DOI: 10.3390/life12050624
PMID: 35629293
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-1729
DOI:10.3390/life12050624