دورية أكاديمية
Clinical Screening for Posterior Cortical Atrophy.
| العنوان: | Clinical Screening for Posterior Cortical Atrophy. |
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| المؤلفون: | Mendez MF; Departments of Neurology.; Psychiatry and Behavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.; Neurology Service, Neurobehavior Unit, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California., Khattab YI; Departments of Neurology., Yerstein O; Department of Neurology, Lahey Hospital and Medical Center, Burlington, Massachusetts. |
| المصدر: | Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology [Cogn Behav Neurol] 2022 Jun 01; Vol. 35 (2), pp. 104-109. Date of Electronic Publication: 2022 Jun 01. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101167278 Publication Model: Electronic Cited Medium: Internet ISSN: 1543-3641 (Electronic) Linking ISSN: 15433633 NLM ISO Abbreviation: Cogn Behav Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins c2003- |
| مواضيع طبية MeSH: | Alzheimer Disease*/diagnostic imaging , Alzheimer Disease*/pathology , Apraxia, Ideomotor*/pathology , Gerstmann Syndrome*/pathology, Atrophy/pathology ; Cerebral Cortex/diagnostic imaging ; Humans ; Neuropsychological Tests |
| مستخلص: | Background: Posterior cortical atrophy (PCA) is a progressive neurologic syndrome that presents with complex visual deficits. Although PCA is most commonly a form of Alzheimer disease (AD), its early diagnosis is usually delayed due to a lack of understanding for how best to clinically screen for the syndrome. Objective: To identify neurobehavioral screening tasks for PCA-beyond simple visual constructions-that can be administered in clinic or at bedside. Method: We compared the performance of 12 individuals who met neuroimaging-supported consensus criteria for PCA with that of 12 matched individuals with typical AD (tAD) and 24 healthy controls (HC) on clinic/bedside tasks measuring (a) complex figure copying, (b) Balint syndrome, (c) visual object agnosia, (d) color identification, (e) figure-ground discrimination, (f) global-local processing, (g) dressing apraxia, (h) ideomotor apraxia, and (i) Gerstmann syndrome. Results: All of the individuals with PCA were impaired on the figure-ground discrimination task compared with half of the tAD group and no HC. Approximately half of the PCA group had Balint syndrome, dressing apraxia, and ideomotor apraxia compared with none in the tAD group. Difficulty copying a complex figure, global-local processing impairment, and Gerstmann syndrome did not distinguish between the two dementia groups. Conclusion: The figure-ground discrimination task can be used successfully as an overall screening measure for PCA, followed by specific tasks for Balint syndrome and dressing and limb apraxia. Findings reinforce PCA as a predominant occipitoparietal disorder with dorsal visual stream involvement and parietal signs with spatiomotor impairments. Competing Interests: The authors declare no conflicts of interest. |
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| معلومات مُعتمدة: | RF1 AG050967 United States AG NIA NIH HHS |
| تواريخ الأحداث: | Date Created: 20220531 Date Completed: 20220602 Latest Revision: 20220607 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/WNN.0000000000000297 |
| PMID: | 35639011 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1543-3641 |
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| DOI: | 10.1097/WNN.0000000000000297 |