دورية أكاديمية
أعرض في EDS

Impact of Syndromes on Sleep-Disordered Breathing in Children After Cleft Palate Repair.

التفاصيل البيبلوغرافية
العنوان: Impact of Syndromes on Sleep-Disordered Breathing in Children After Cleft Palate Repair.
المؤلفون: Poupore NS; Medical University of South Carolina, Charleston, SC, USA., Jungbauer WN; Medical University of South Carolina, Charleston, SC, USA., Smaily H; Medical University of South Carolina, Charleston, SC, USA., Carroll WW; Medical University of South Carolina, Charleston, SC, USA., Pecha PP; Medical University of South Carolina, Charleston, SC, USA.
المصدر: The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association [Cleft Palate Craniofac J] 2023 Nov; Vol. 60 (11), pp. 1419-1425. Date of Electronic Publication: 2022 May 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications in Association with American Cleft Palate-Craniofacial Association Country of Publication: United States NLM ID: 9102566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-1569 (Electronic) Linking ISSN: 10556656 NLM ISO Abbreviation: Cleft Palate Craniofac J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : [Thousand Oaks, CA] : SAGE Publications in Association with American Cleft Palate-Craniofacial Association
Original Publication: Pittsburgh, PA : The Association, [1991-
مواضيع طبية MeSH: Cleft Palate*/surgery , Cleft Palate*/complications , Sleep Apnea Syndromes*/diagnosis , Sleep Apnea, Obstructive*/etiology , Pierre Robin Syndrome*/surgery , Pierre Robin Syndrome*/complications, Child ; Humans ; Infant ; Retrospective Studies
مستخلص: Objective: Prior research suggests that children with cleft palate (CP) are at increased risk of obstructive sleep-disordered breathing (SDB). However, few studies differentiate the effects of CP repair on SDB based on syndrome status. The goal of this study was to evaluate differences in SDB after palatoplasty among children with nonsyndromic CP, syndromic CP, and isolated Robin sequence (RS).
Design: Retrospective chart review.
Setting: Tertiary academic children's hospital.
Patients/participants: A total of 145 children who underwent primary CP repair from 2014 to 2021.
Main Outcome Measure: Post-palatoplasty SDB is defined as parent-reported symptoms and/or evidence of obstructive sleep apnea (OSA).
Results: Median age at palatoplasty was 11.1 [IQR 10.2-13.6] months. Most patients (61.4%) had nonsyndromic CP, 26.9% had a syndrome, and 11.7% had RS. Children with syndromic CP and RS had more post-palatoplasty SDB symptoms (56.4% vs 58.8% vs 30.3%, P  = .006) and higher rates of OSA (25.6% vs 29.4% vs 5.6%, P  = .001) compared to children with nonsyndromic CP after palatoplasty. Children with syndromic CP and RS had nearly 3 to 4 higher odds of post-palatoplasty SDB than children with nonsyndromic CP (adjusted odds ratio [aOR] 2.88, 95% CI 1.29-6.47, P  = .010; aOR 3.73, 95% CI 1.19-11.70, P  = .024).
Conclusion: This study showed that children with CP experience higher rates of SDB after palatoplasty than the general pediatric population. Within the cohort, children with syndromic CP and isolated RS were more likely to have obstructive sleep disorders than nonsyndromic children after palatoplasty. Clinicians should counsel caregivers accordingly and closely monitor these groups for SDB after palate repair.
Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
معلومات مُعتمدة: UL1 TR001450 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Pierre Robin sequence; nonsyndromic clefting; palatoplasty; sleep disorders
تواريخ الأحداث: Date Created: 20220601 Date Completed: 20231004 Latest Revision: 20231102
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10083050
DOI: 10.1177/10556656221105203
PMID: 35642260
قاعدة البيانات: MEDLINE
الوصف
تدمد:1545-1569
DOI:10.1177/10556656221105203