دورية أكاديمية
Patient-Reported Sexual Function in Long-Term Survivors of Anal Cancer Treated With Definitive Intensity Modulated Radiation Therapy and Concurrent Chemotherapy.
| العنوان: | Patient-Reported Sexual Function in Long-Term Survivors of Anal Cancer Treated With Definitive Intensity Modulated Radiation Therapy and Concurrent Chemotherapy. |
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| المؤلفون: | Corrigan KL; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Rooney MK; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., De B; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Ludmir ED; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas; Departments of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas., Das P; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Smith GL; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Taniguchi C; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Minsky BD; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Koay EJ; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Koong A; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Morris VK; Departments of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas., Messick CA; Departments of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas., Nogueras-Gonzalez G; Departments of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas., Holliday EB; Departments of Gastrointestinal Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ebholliday@mdanderson.org. |
| المصدر: | Practical radiation oncology [Pract Radiat Oncol] 2022 Sep-Oct; Vol. 12 (5), pp. e397-e405. Date of Electronic Publication: 2022 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101558279 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-8519 (Electronic) Linking ISSN: 18798500 NLM ISO Abbreviation: Pract Radiat Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York : Elsevier |
| مواضيع طبية MeSH: | Anus Neoplasms*/radiotherapy , Carcinoma, Squamous Cell* , Erectile Dysfunction* , Sexual Dysfunction, Physiological*/epidemiology , Sexual Dysfunction, Physiological*/etiology, Aged ; Female ; Humans ; Male ; Middle Aged ; Patient Reported Outcome Measures ; Survivors |
| مستخلص: | Purpose: Pelvic chemoradiation can have a profound effect on sexual function. Few data exist describing long-term sexual function patient-reported outcomes (PROs) for patients treated with intensity modulated radiation and concurrent chemotherapy (CRT) for squamous cell carcinoma of the anus (SCCA). Methods and Materials: We identified 248 patients with SCCA treated with CRT from 2010 to 2018 who were alive and without recurrence. We sent a PRO survey to 148 patients who agreed to participate. The survey was comprised of the PROMIS sexual function and satisfaction questionnaire, the international index of erectile function 5-item questionnaire for men, and the female sexual function index questionnaire for women. Clinical and dosimetric data were collected for each patient. We used multiple regression models to identify factors associated with sexual function PROs. Results: One-hundred twelve patients (45.2% of all eligible patients, 75.7% of administered surveys) completed the survey; 90 (80.4%) were women, 107 (95.5%) were white. The median (interquartile range [IQR]) age was 61.5 (53.8-66.0) years. The median (IQR) interval since CRT was 51 (37-85) months. Twelve men (54.5%) and 52 women (57.1%) were sexually active. The median (IQR) age of sexually active patients was 58.2 (50.1-64) years compared with 64.8 (59.1-68.8) years for sexually inactive patients (P < .001). The median (IQR) female sexual function index score for sexually active women was 20.2 (13.6-25.1). The median (IQR) international index of erectile function 5-item questionnaire score was 14 (6.5-19). Conclusions: Patients treated with modern CRT for SCCA experience significant long-term sexual dysfunction as reported using validated PROs. Interventions to reduce sexual toxicities and improve patient support are needed. (Copyright © 2022 American Society for Radiation Oncology. Published by Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20220601 Date Completed: 20220907 Latest Revision: 20220907 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.prro.2022.05.006 |
| PMID: | 35643295 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-8519 |
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| DOI: | 10.1016/j.prro.2022.05.006 |