دورية أكاديمية
Botulinum toxin type A for lower limb lengthening and deformity correction: A systematic review and meta-analysis.
| العنوان: | Botulinum toxin type A for lower limb lengthening and deformity correction: A systematic review and meta-analysis. |
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| المؤلفون: | Ghaddaf AA; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Electronic address: abdullahg.official@gmail.com., Alsharef JF; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Electronic address: Jawaheralsharef036@gmail.com., Alomari MS; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Electronic address: mohamad201025@gmail.com., Al Qurashi AA; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Electronic address: abdullah5ksau@gmail.com., Abdulhamid AS; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. Electronic address: newahmed19@hotmail.com., Alshehri MS; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Surgery/Orthopedic Section, King Abdulaziz Medical City, Jeddah, Saudi Arabia. Electronic address: drmshehri@gmail.com., Alosaimi M; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia; Department of Surgery/Orthopedic Section, King Abdulaziz Medical City, Jeddah, Saudi Arabia. Electronic address: majedalosaimi@gmail.com. |
| المصدر: | Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association [J Orthop Sci] 2023 Jul; Vol. 28 (4), pp. 806-813. Date of Electronic Publication: 2022 May 26. |
| نوع المنشور: | Meta-Analysis; Systematic Review; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Japan NLM ID: 9604934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-2023 (Electronic) Linking ISSN: 09492658 NLM ISO Abbreviation: J Orthop Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Tokyo : Elsevier Original Publication: Tokyo : Springer-Verlag Tokyo, c1996- |
| مواضيع طبية MeSH: | Botulinum Toxins, Type A*/therapeutic use , Bone Lengthening*, Humans ; Analgesics, Opioid ; Lower Extremity/surgery ; Pain, Postoperative/drug therapy |
| مستخلص: | Background: Botulinum toxin type A (BTX-A) is the most popular therapeutic agent for muscle relaxation and pain control. Lately, BTX-A injection received great interest as a part of multimodal pain management for lower limb lengthening and deformity correction. This systematic review aimed to determine the role of BTX-A injection in pain management for during lower limb lengthening and/or deformity correction. Methods: We searched Medline, Embase, and CENTRAL. We included randomized controlled trials (RCTs) that compared the BTX-A injection to placebo for individuals undergoing lower limb lengthening and/or deformity correction. We sought to evaluate the following outcomes: pain on visual analogue scale (VAS), range of motion parameters, average opioid consumption, and adverse events. The standardized mean difference (SMD) was used to represent continuous outcomes while risk ratio (RR) was used to represent dichotomous outcomes. Results: A total of 4 RCTs that enrolled 257 participants (337 limbs) deemed eligible. Adjuvant BTX-A injection showed a significant reduction in post-operative pain compared to placebo (SMD = -0.28, 95% CI -0.53 to -0.04). No difference was found between BTX-A injection and placebo in terms of range of motion parameters, average opioid consumption, or adverse events after surgical limb lengthening and/or deformity correction (RR = 0.77, 95% CI -0.58 to 1.03). Conclusions: Adjuvant BTX-A injection conferred a discernible reduction in post-operative pain during surgical limb lengthening and/or deformity without increasing the risk of adverse events. Prospero Registration Number: CRD42021271580. Competing Interests: Declaration of competing interest Each author certifies that there are no funding or commercial associations that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. (Copyright © 2022 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Botulinum toxin type A; Deformity correction; Distraction osteogenesis; Limb lengthening; Pain management |
| المشرفين على المادة: | EC 3.4.24.69 (Botulinum Toxins, Type A) 0 (Analgesics, Opioid) |
| تواريخ الأحداث: | Date Created: 20220601 Date Completed: 20230710 Latest Revision: 20230718 |
| رمز التحديث: | 20230718 |
| DOI: | 10.1016/j.jos.2022.04.011 |
| PMID: | 35643907 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1436-2023 |
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| DOI: | 10.1016/j.jos.2022.04.011 |