دورية أكاديمية
Incidence and factors associated with acute kidney injury among children with type 1 diabetes hospitalized with diabetic ketoacidosis: A prospective study.
| العنوان: | Incidence and factors associated with acute kidney injury among children with type 1 diabetes hospitalized with diabetic ketoacidosis: A prospective study. |
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| المؤلفون: | Hegab AM; Pediatrics Department, Faculty of Medicine, Sohag University, Sohag, Egypt., Khalil FF; Pediatrics Department, Faculty of Medicine, Sohag University, Sohag, Egypt., Abosedera MM; Pediatrics Department, Faculty of Medicine, Sohag University, Sohag, Egypt. |
| المصدر: | Pediatric diabetes [Pediatr Diabetes] 2022 Sep; Vol. 23 (6), pp. 783-791. Date of Electronic Publication: 2022 Jun 10. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Munksgaard Country of Publication: Denmark NLM ID: 100939345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1399-5448 (Electronic) Linking ISSN: 1399543X NLM ISO Abbreviation: Pediatr Diabetes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Copenhagen : Munksgaard, c2000- |
| مواضيع طبية MeSH: | Acute Kidney Injury*/epidemiology , Acute Kidney Injury*/etiology , Acute Kidney Injury*/therapy , Diabetes Mellitus, Type 1*/complications , Diabetes Mellitus, Type 1*/diagnosis , Diabetes Mellitus, Type 1*/epidemiology , Diabetic Ketoacidosis*/epidemiology , Diabetic Ketoacidosis*/etiology , Diabetic Ketoacidosis*/therapy, Child ; Chlorides ; Creatinine ; Humans ; Incidence ; Prospective Studies ; Retrospective Studies |
| مستخلص: | Background and Objectives: Acute kidney injury (AKI) is frequent among critically ill children. This study aimed to assess the incidence and factors associated with AKI among children with type 1 diabetes mellitus (T1DM) hospitalized with diabetic ketoacidosis (DKA). Methods: This prospective observational study was conducted at Sohag University Hospital, Egypt over 1 year. Children aged 6 months to 12 years, diagnosed with T1DM and hospitalized with the criteria of DKA were included. The study participants received intravenous fluid therapy and intravenous insulin infusion for DKA management. Serum creatinine levels were measured at admission, 24 and 48 h after admission. AKI was defined and staged using the Kidney Disease Improving Global Outcomes serum creatinine criteria. Results: The study included 265 DKA episodes in 240 participants. AKI was found in 110 (41.5%) DKA episodes. Moderated to severe AKI developed in 41 (15.5%) episodes. Multivariate regression analysis revealed that age (adjusted odds ratio = 0.78, 95% confidence interval (CI): 0.69-0.89, p < 0.001), Glasgow-Coma scale (GCS) < 14 at admission (adjusted odds ratio = 4.66, 95% CI: 1.66-13.14, p = 0.004) and serum chloride level at 12 h (adjusted odds ratio = 1.10, 95% CI: 1.02-1.18, p = 0.01) were the most significant factors associated with moderate to severe AKI development. Conclusions: AKI is common among T1DM children hospitalized with DKA. Younger age, low GCS at hospital admission and increased serum chloride level during DKA management were associated with increased risk for moderate to severe AKI development. (© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
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| فهرسة مساهمة: | Keywords: acute kidney injury; children; diabetic ketoacidosis; type 1 diabetes |
| المشرفين على المادة: | 0 (Chlorides) AYI8EX34EU (Creatinine) |
| تواريخ الأحداث: | Date Created: 20220601 Date Completed: 20220809 Latest Revision: 20220902 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/pedi.13370 |
| PMID: | 35644034 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1399-5448 |
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| DOI: | 10.1111/pedi.13370 |