دورية أكاديمية
أعرض في EDS

Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.

التفاصيل البيبلوغرافية
العنوان: Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.
المؤلفون: Huang H; Department of Blood Transfusion, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, Guangdong, China., Bai X; Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.; Department of Anesthesiology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China., Zhang K; Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Guo J; Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Wu S; Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Ouyang H; Department of Anesthesiology, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
المصدر: Pain research & management [Pain Res Manag] 2022 May 18; Vol. 2022, pp. 4819910. Date of Electronic Publication: 2022 May 18 (Print Publication: 2022).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 9612504 Publication Model: eCollection Cited Medium: Internet ISSN: 1918-1523 (Electronic) Linking ISSN: 12036765 NLM ISO Abbreviation: Pain Res Manag Subsets: MEDLINE
أسماء مطبوعة: Publication: <2015- > : New York, NY : Hindawi Publishing Corporation
Original Publication: Oakville, Ont. : Pulsus Group, 1996-
مواضيع طبية MeSH: Neostigmine*/pharmacology , Neostigmine*/therapeutic use , Pentazocine*/therapeutic use, Analgesics/therapeutic use ; Animals ; Atropine Derivatives/therapeutic use ; Clonidine/pharmacology ; Clonidine/therapeutic use ; Formaldehyde/therapeutic use ; Humans ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Naloxone/therapeutic use ; Narcotic Antagonists/pharmacology ; Narcotic Antagonists/therapeutic use ; Pain/drug therapy ; Pain/etiology ; Rats ; Rats, Sprague-Dawley
مستخلص: Background: Pentazocine produces a wide variety of actions in the treatment of perioperative analgesia. Neostigmine is a cholinesterase inhibitor used to antagonize the residual effects of muscle relaxants and also produces an analgesic effect.
Objectives: To investigate the analgesic effects of intrathecally injected pentazocine and neostigmine and their interaction.
Methods: Sprague-Dawley rats were used to test the analgesic effect of pentazocine and neostigmine using the paw formalin pain model and the incision mechanical allodynia model. Pentazocine (3, 10, 30, and 100  μ g), neostigmine (0.3, 1, 3, and 10  μ g) or a pentazocine-neostigmine mixture were separately injected to evaluate their antinociceptive effects alone on the treatment groups. The corresponding control group received an intrathecal injection containing the same volume of saline. The formalin pain test, or the plantar incision pain behavior test were performed 30 minutes later. Isobolographic analysis was used to evaluate the interaction between pentazocine and neostigmine. Intrathecally administered selective mu-opioid receptor antagonist CTAP, selective kappa-opioid receptor antagonist nor-Binaltorphimine (nor-BNI), nonselective opioid receptor antagonist naloxone, and muscarinic acetylcholine receptor antagonist atropine were also used to test the possible interaction mechanism. These antagonists were used 30 minutes before the pentazocine and neostigmine mixtures which were intrathecally injected.
Results: Intrathecally administered pentazocine (3, 10, 30, and 100  μ g) and neostigmine (0.3, 1, 3, and 10  μ g) alone had a marked dose-related impact on suppressing the biphasic responses in the formalin test. Pentazocine (3, 10, 30, and 100  μ g) and neostigmine (0.3, 1, 3, and 10  μ g) alone attenuated the mechanical allodynia in a plantar incision model in a dose-dependent manner. Isobolographic analysis revealed that the mixture of intrathecal pentazocine and neostigmine synergistically decreased both phase I and II activity in the formalin test and mechanical allodynia in the plantar incision model. Pretreatment of intrathecally administered nor-BNI, naloxone, atropine, but not CTAP, antagonized the analgesic effect of the pentazocine-neostigmine mixture.
Conclusions: All of these results suggest that the combined application of pentazocine and neostigmine is an effective way to relieve pain from formalin and acute incision mechanical allodynia. The synergistic effect between pentazocine and neostigmine is mostly attributed to the kappa-opioid receptor and the cholinergic receptor in the spinal cord.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2022 Huiying Huang et al.)
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المشرفين على المادة: 0 (Analgesics)
0 (Atropine Derivatives)
0 (Narcotic Antagonists)
1HG84L3525 (Formaldehyde)
36B82AMQ7N (Naloxone)
3982TWQ96G (Neostigmine)
MN3L5RMN02 (Clonidine)
RP4A60D26L (Pentazocine)
تواريخ الأحداث: Date Created: 20220601 Date Completed: 20220603 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9132711
DOI: 10.1155/2022/4819910
PMID: 35646201
قاعدة البيانات: MEDLINE
الوصف
تدمد:1918-1523
DOI:10.1155/2022/4819910