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Silent Corticotroph and Somatotroph Double Pituitary Adenoma: A Case Report and Review of Literature.

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العنوان: Silent Corticotroph and Somatotroph Double Pituitary Adenoma: A Case Report and Review of Literature.
المؤلفون: Pecorari IL; Department of Neurological Surgery, Albert Einstein College of Medicine, Bronx, New York, United States.; Department of Neurological Surgery, Montefiore Medical Center, Bronx, New York, United States., Mahali LP; Department of Endocrinology, Albert Einstein College of Medicine, Bronx, New York, United States.; Department of Endocrinology, Montefiore Medical Center, Bronx, New York, United States., Funari A; Department of Neurological Surgery, Albert Einstein College of Medicine, Bronx, New York, United States.; Department of Neurological Surgery, Montefiore Medical Center, Bronx, New York, United States., Fecher R; Department of Anatomic and Clinical Pathology, Albert Einstein College of Medicine, Bronx, New York, United States.; Department of Anatomic and Clinical Pathology, Montefiore Medical Center, Bronx, New York, United States., Suda N; Department of Endocrinology, Albert Einstein College of Medicine, Bronx, New York, United States.; Department of Endocrinology, Montefiore Medical Center, Bronx, New York, United States., Agarwal V; Department of Neurological Surgery, Albert Einstein College of Medicine, Bronx, New York, United States.; Department of Neurological Surgery, Montefiore Medical Center, Bronx, New York, United States.
المصدر: Journal of neurological surgery reports [J Neurol Surg Rep] 2022 May 27; Vol. 83 (2), pp. e33-e38. Date of Electronic Publication: 2022 May 27 (Print Publication: 2022).
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Thieme Country of Publication: Germany NLM ID: 101601540 Publication Model: eCollection Cited Medium: Print ISSN: 2193-6358 (Print) Linking ISSN: 21936358 NLM ISO Abbreviation: J Neurol Surg Rep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Stuttgart : Thieme
مستخلص: Clinically silent double pituitary adenomas consisting of corticotroph and somatotroph cells are an exceedingly rare clinical finding. In this report, we present the case of a 28-year-old man with a 1-year history of recurrent headaches. Imaging revealed a 2.1 (anterior-posterior) × 2.2 (transverse) × 1.3 (craniocaudal) cm pituitary adenoma invading into the left cavernous sinus and encasing the left internal carotid artery. Endoscopic transnasal resection was performed without complications. Immunohistochemical staining revealed a double adenoma consisting of distinct sparsely granulated somatotroph and densely granulated corticotroph cells that were positive for growth hormone and adrenocorticotropic hormone, respectively. K i -67 index labeling revealed a level of 6% within the corticotroph adenoma. No increase in serum growth hormone or adrenocorticotropic hormone was found, indicating a clinically silent double adenoma. While transsphenoidal surgery remains a first-line approach for silent adenomas presenting with mass effects, increased rates of proliferative markers, such as the K i -67 index, provide useful insight into the clinical course of such tumors. Determining the K i -67 index of silent pituitary adenomas could be valuable in predicting recurrence after initial surgical resection and identifying tumors that are at an increased risk of needing additional therapeutic interventions or more frequent surveillance imaging.
Competing Interests: Conflict of Interest None declared.
(The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
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فهرسة مساهمة: Keywords: K i -67; corticotroph; double pituitary adenoma; somatotroph
تواريخ الأحداث: Date Created: 20220601 Latest Revision: 20220716
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9142216
DOI: 10.1055/s-0042-1749389
PMID: 35646510
قاعدة البيانات: MEDLINE
الوصف
تدمد:2193-6358
DOI:10.1055/s-0042-1749389