دورية أكاديمية
أعرض في EDS

Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.

التفاصيل البيبلوغرافية
العنوان: Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate.
المؤلفون: Carrettiero DC; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA.; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, SP, Brazil., Almeida MC; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA.; Center for Natural and Human Sciences, Federal University of ABC, São Bernardo do Campo, SP, Brazil., Longhini AP; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Rauch JN; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Han D; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Zhang X; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA., Najafi S; Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, USA., Gestwicki JE; Institute for Neurodegenerative Disease, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA., Kosik KS; Neuroscience Research Institute, Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA, USA. kosik@lifesci.ucsb.edu.
المصدر: Nature communications [Nat Commun] 2022 Jun 02; Vol. 13 (1), pp. 3074. Date of Electronic Publication: 2022 Jun 02.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Proteasome Endopeptidase Complex*/metabolism , Ubiquitin*/metabolism, Autophagy ; Humans ; Molecular Chaperones/metabolism ; Proteolysis
مستخلص: The formation of membraneless organelles can be a proteotoxic stress control mechanism that locally condenses a set of components capable of mediating protein degradation decisions. The breadth of mechanisms by which cells respond to stressors and form specific functional types of membraneless organelles, is incompletely understood. We found that Bcl2-associated athanogene 2 (BAG2) marks a distinct phase-separated membraneless organelle, triggered by several forms of stress, particularly hyper-osmotic stress. Distinct from well-known condensates such as stress granules and processing bodies, BAG2-containing granules lack RNA, lack ubiquitin and promote client degradation in a ubiquitin-independent manner via the 20S proteasome. These organelles protect the viability of cells from stress and can traffic to the client protein, in the case of Tau protein, on the microtubule. Components of these ubiquitin-independent degradation organelles include the chaperone HSP-70 and the 20S proteasome activated by members of the PA28 (PMSE) family. BAG2 condensates did not co-localize with LAMP-1 or p62/SQSTM1. When the proteasome is inhibited, BAG2 condensates and the autophagy markers traffic to an aggresome-like structure.
(© 2022. The Author(s).)
References: FEBS Lett. 2010 Apr 2;584(7):1393-8. (PMID: 20040365)
Nat Methods. 2019 Dec;16(12):1226-1232. (PMID: 31570887)
Nat Commun. 2021 Feb 17;12(1):1085. (PMID: 33597515)
EMBO J. 2003 Apr 1;22(7):1488-96. (PMID: 12660156)
Cell. 2020 Apr 16;181(2):306-324.e28. (PMID: 32302570)
J Biol Chem. 2012 Jan 20;287(4):2446-58. (PMID: 22147700)
J Biol Chem. 2004 Oct 1;279(40):41815-21. (PMID: 15271996)
BMC Biol. 2012 Mar 15;10:22. (PMID: 22420755)
Nature. 2020 May;581(7807):209-214. (PMID: 32405004)
Nat Commun. 2021 Mar 1;12(1):1353. (PMID: 33649309)
Nature. 2012 Mar 07;483(7389):336-40. (PMID: 22398450)
Mol Biol Cell. 2005 Dec;16(12):5891-900. (PMID: 16207813)
Nat Struct Mol Biol. 2008 Dec;15(12):1309-17. (PMID: 19029896)
Nat Cell Biol. 2021 Mar;23(3):257-267. (PMID: 33723425)
PLoS One. 2013 Aug 05;8(8):e70687. (PMID: 23940626)
Exp Neurol. 2016 Jan;275 Pt 1:69-77. (PMID: 26496817)
Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):106-11. (PMID: 25535373)
Transl Res. 2018 Aug;198:48-57. (PMID: 30244692)
J Cell Biol. 2020 Nov 2;219(11):. (PMID: 32997736)
Front Cell Dev Biol. 2018 Oct 02;6:128. (PMID: 30333975)
Biochem J. 2003 Jul 1;373(Pt 1):71-9. (PMID: 12650640)
J Biol Chem. 2014 Jan 17;289(3):1402-14. (PMID: 24318877)
Biochem J. 2000 Jan 1;345 Pt 1:1-15. (PMID: 10600633)
Nat Chem. 2017 Nov;9(11):1118-1125. (PMID: 29064502)
J Biol Chem. 2001 Nov 16;276(46):42938-44. (PMID: 11557750)
Cell Mol Biol Lett. 2016 Dec 13;21:29. (PMID: 28536631)
Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118795. (PMID: 32668274)
Biophys J. 2008 Feb 15;94(4):1437-48. (PMID: 17933881)
Genetics. 2014 Mar;196(3):605-13. (PMID: 24361941)
Biochem Biophys Res Commun. 2001 Dec 21;289(5):1099-105. (PMID: 11741305)
J Mol Biol. 2021 May 14;433(10):166948. (PMID: 33744316)
Biophys J. 2021 Jun 1;120(11):2181-2191. (PMID: 33798566)
Arch Biochem Biophys. 2010 Aug 15;500(2):181-8. (PMID: 20478262)
J Mol Neurosci. 2015 Sep;57(1):83-9. (PMID: 25985852)
ACS Chem Biol. 2012 Oct 19;7(10):1677-86. (PMID: 22769591)
Science. 2017 Sep 22;357(6357):. (PMID: 28935776)
J Biol Chem. 2007 Aug 17;282(33):24131-45. (PMID: 17580304)
Elife. 2016 Sep 23;5:. (PMID: 27661255)
Cell. 2018 Jul 26;174(3):688-699.e16. (PMID: 29961577)
J Cell Biol. 2005 Nov 21;171(4):603-14. (PMID: 16286508)
Sci Rep. 2018 Apr 23;8(1):6382. (PMID: 29686391)
Sci Adv. 2020 Jul 22;6(30):eaba3916. (PMID: 32832664)
Neuroscience. 2016 Jun 2;324:20-8. (PMID: 26944602)
PLoS One. 2018 Jan 2;13(1):e0183585. (PMID: 29293509)
Nat Methods. 2007 Nov;4(11):963-73. (PMID: 17971781)
J Neurosci. 2009 Feb 18;29(7):2151-61. (PMID: 19228967)
Nat Methods. 2012 Oct;9(10):1005-12. (PMID: 22961245)
Cell. 2019 Jan 10;176(1-2):407. (PMID: 30633909)
Cell Mol Life Sci. 2008 May;65(9):1390-402. (PMID: 18264803)
Nat Commun. 2018 Mar 15;9(1):1097. (PMID: 29545515)
Autophagy. 2014 Sep;10(9):1603-21. (PMID: 25046115)
Trends Biochem Sci. 2008 Mar;33(3):141-50. (PMID: 18291657)
Genes Dev. 2008 Jun 1;22(11):1427-38. (PMID: 18519635)
Mol Cell. 2020 Sep 17;79(6):978-990.e5. (PMID: 32857953)
Nature. 2020 Feb;578(7794):296-300. (PMID: 32025036)
Cell Stress Chaperones. 2000 Apr;5(2):73-5. (PMID: 11147967)
Biomolecules. 2021 Feb 05;11(2):. (PMID: 33562807)
Cell. 2020 Dec 10;183(6):1699-1713.e13. (PMID: 33188775)
J Neurosci. 1996 Dec 15;16(24):7812-20. (PMID: 8987809)
J Cell Biol. 1998 Dec 28;143(7):1883-98. (PMID: 9864362)
J Biol Chem. 2005 Nov 18;280(46):38673-81. (PMID: 16169850)
Aging Cell. 2018 Feb;17(1):. (PMID: 29024336)
Development. 2019 Jan 25;146(12):. (PMID: 30642837)
معلومات مُعتمدة: R01 AG056058 United States AG NIA NIH HHS; R01 NS059690 United States NS NINDS NIH HHS; U54 NS100717 United States NS NINDS NIH HHS
المشرفين على المادة: 0 (BAG2 protein, human)
0 (Molecular Chaperones)
0 (Ubiquitin)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
تواريخ الأحداث: Date Created: 20220602 Date Completed: 20220606 Latest Revision: 20240514
رمز التحديث: 20240514
مُعرف محوري في PubMed: PMC9163039
DOI: 10.1038/s41467-022-30751-4
PMID: 35654899
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-022-30751-4