دورية أكاديمية
Relationship of vitamin D levels with clinical presentation and recurrence of BPPV in a Southeastern United States institution.
| العنوان: | Relationship of vitamin D levels with clinical presentation and recurrence of BPPV in a Southeastern United States institution. |
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| المؤلفون: | Cobb LH; Department of Otolaryngology; Medical University of South Carolina, Charleston, SC, USA., Bailey VO; Department of Otolaryngology; Medical University of South Carolina, Charleston, SC, USA., Liu YF; Department of Otolaryngology, Head and Neck Surgery, Loma Linda University Health, Loma Linda, CA, USA., Teixido MT; Department of Otolaryngology, University of Pennsylvania, Philadelphia, PA, USA., Rizk HG; Department of Otolaryngology; Medical University of South Carolina, Charleston, SC, USA. Electronic address: rizkh@musc.edu. |
| المصدر: | Auris, nasus, larynx [Auris Nasus Larynx] 2023 Feb; Vol. 50 (1), pp. 70-80. Date of Electronic Publication: 2022 Jun 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7708170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1476 (Electronic) Linking ISSN: 03858146 NLM ISO Abbreviation: Auris Nasus Larynx Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science Original Publication: Tokyo, Society for Promotion of International Otorhinolaryngology. |
| مواضيع طبية MeSH: | Vitamin D* , Vitamin D Deficiency*/epidemiology, Humans ; Female ; Middle Aged ; Aged ; Nutrition Surveys ; Retrospective Studies ; Prospective Studies ; Cross-Sectional Studies ; Benign Paroxysmal Positional Vertigo/etiology |
| مستخلص: | Objective: To examine the relationship of 25hydroxyvitamin D serum levels with BPPV incidence and recurrence rates. Methods: A retrospective cross-sectional, case-controlled study with follow-up phone survey was performed on patients diagnosed with BPPV between 05/2017-05/2020, who had available 25hydroxyvitamin D serology. Patients were seen at a multidisciplinary, vestibular-focused, neurotology clinic at a tertiary referral center. Controls consisted of subjects from the National Health and Nutrition Examination Survey (NHANES), and a locoregional age, sex, and race-matched group of patients from our institution. Results: Our BPPV cohort consisted of 173 patients (mean age 66.2 ± 11.8 years), who were predominately female (75.7%) and Caucasian (76.3%). Almost all age subgroups (BPPV, NHANES, and locoregional groups) ≤60 years old had insufficient levels of vitamin D. However, the overall BPPV cohort had a significantly higher vitamin D level than the NHANES control (31.4 ± 16.5 v. 26.0 ± 11.2 ng/mL, d=0.474 [0.323, 0.626]). There was no significant difference when compared to the overall locoregional control (31.4 ± 20.5 ng/mL). Migraines were significantly correlated to increased BPPV recurrence rates on univariate (beta=0.927, p=0.037, 95% CI: [0.057, 1.798]) and multiple regression analyses (beta=0.231, 95% CI: [0.024, 2.029], p=0.045). Furthermore, patients with BPPV recurrences had significantly lower levels of vitamin D at initial presentation when compared to patients with no recurrences (29.0 ± 12.0 v. 37.6 ± 18.3 ng/mL, d=0.571[0.139,1.001]). Conclusion: Many BPPV patients in our cohort had insufficient vitamin D levels, and patients with BPPV recurrences had insufficient and significantly lower vitamin D levels than those without. As a readily available and affordable supplement, vitamin D may be used as an adjunct treatment but prospective studies should be done to confirm if it can prevent or reduce recurrence. Competing Interests: Conflict of Interest There are no conflicts of interest. (Copyright © 2022. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: BPPV; Benign paroxysmal positional vertigo; Vitamin D; Vitamin D deficiency |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) |
| تواريخ الأحداث: | Date Created: 20220606 Date Completed: 20230127 Latest Revision: 20230202 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.anl.2022.05.011 |
| PMID: | 35659787 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1879-1476 |
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| DOI: | 10.1016/j.anl.2022.05.011 |