RBP-J deficiency promoted the proliferation and differentiation of CD133-positive cells in both in vitro and in vivo studies.

التفاصيل البيبلوغرافية
العنوان:	RBP-J deficiency promoted the proliferation and differentiation of CD133-positive cells in both in vitro and in vivo studies.
المؤلفون:	Ye X; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Li M; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Bian W; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Wu A; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Zhang T; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Li J; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Zhou P; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Cui H; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Ding YQ; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Liao M; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Department of Histology and Embryology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China., Sun C; Department of Anatomy, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.; Institute of Neuroscience, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, China.
المصدر:	The European journal of neuroscience [Eur J Neurosci] 2022 Jul; Vol. 56 (2), pp. 3839-3860. Date of Electronic Publication: 2022 Jun 14.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE
أسماء مطبوعة:	Publication: : Oxford : Wiley-Blackwell Original Publication: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press, c1989-
مواضيع طبية MeSH:	Immunoglobulin J Recombination Signal Sequence-Binding Protein/genetics , Immunoglobulin J Recombination Signal Sequence-Binding Protein/metabolism , Neural Stem Cells*/metabolism, Animals ; Cell Differentiation/physiology ; Cell Proliferation ; Mice ; Neurogenesis/physiology
مستخلص:	Although Notch signalling pathway could control the proliferation and differentiation of neural stem cells (NSCs), it is largely unknown about the effect of Notch signalling pathway on the neurogenesis of CD133-positive cells. By using the primary cultured ependymal cells and the transgenic mouse, we found that CD133 immunoreactivity was exclusively localized in the ependymal layer of ventricles; moreover, most CD133-positive cells were co-labelled with Nestin. In addition, recombination signal binding protein J (RBP-J), a key nuclear effector of Notch signalling pathway, was highly active in CD133-positive cells. CD133-positive cells can differentiate into the immature and mature neurons; in particular, the number of CD133-positive cells differentiating into the immature and mature neurons was significantly increased following the deficiency or interference of RBP-J in vivo or in vitro. By using real-time qPCR and Western blot, we found that RBP-J and Hes1 were downregulated, whereas Notch1 was upregulated in the expression levels of mRNAs and proteins following the deficiency or interference of RBP-J. These results demonstrated RBP-J deficiency promoted the proliferation and differentiation of CD133-positive cells. Therefore, we speculated that RBP-J could maintain CD133-positive cells in the characteristics of NSCs possibly by regulating Notch1/RBP-J/Hes1 pathway. It will provide a novel molecular insight into the function of RBP-J as well as facilitate a future investigation of CD133-positive cells with respect to their potential application in neurodegenerative disorder. (© 2022 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
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فهرسة مساهمة:	Keywords: CD133-positive cell; RBP-J; cell proliferation and differentiation; neural stem cell; notch signalling pathway
المشرفين على المادة:	0 (Immunoglobulin J Recombination Signal Sequence-Binding Protein) 0 (Rbpj protein, mouse)
تواريخ الأحداث:	Date Created: 20220606 Date Completed: 20220715 Latest Revision: 20221004
رمز التحديث:	20221213
DOI:	10.1111/ejn.15727
PMID:	35661443
قاعدة البيانات:	MEDLINE

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تدمد:	1460-9568
DOI:	10.1111/ejn.15727