دورية أكاديمية
أعرض في EDS

Differences in gene expression despite identical histomorphology in sinonasal intestinal-type adenocarcinoma and metastases from colorectal adenocarcinoma.

التفاصيل البيبلوغرافية
العنوان: Differences in gene expression despite identical histomorphology in sinonasal intestinal-type adenocarcinoma and metastases from colorectal adenocarcinoma.
المؤلفون: Sjöstedt S; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark., Vieira FG; Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark., Karnov K; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark., Agander TK; Department of Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Willemoe GL; Department of Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark., Rohrberg KS; Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark., Nielsen FC; Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark., von Buchwald C; Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark.
المصدر: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica [APMIS] 2022 Sep; Vol. 130 (9), pp. 551-559. Date of Electronic Publication: 2022 Jun 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 8803400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0463 (Electronic) Linking ISSN: 09034641 NLM ISO Abbreviation: APMIS Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Munksgaard
Original Publication: Copenhagen : Munksgaard, c1988-
مواضيع طبية MeSH: Adenocarcinoma*/pathology , Colorectal Neoplasms*/pathology, Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Gene Expression ; Humans
مستخلص: Sinonasal intestinal-type adenocarcinoma (sITAC) is histomorphologically indistinguishable from colorectal adenocarcinoma (CRC) leading to diagnostic challenges. Metastases from CRCs to the sinonasal tract have been reported. The aim of the study was to identify a biomarker making it possible to distinguish between sITAC and metastases of colorectal origin. Formalin-fixated paraffin-embedded (FFPE) tissue from 20 consecutive patients with sITAC treated at Rigshospitalet, Denmark from 2005 to 2017, 20 patients with CRC, and second patients with both sinonasal and colorectal carcinomas were included, and RNA-sequencing was performed on all samples. Moreover, a series of 26 samples from metastasizing CRC were included (in-house data). 3139 differentially expressed genes were identified, of these several were deemed as possible biomarkers, including CSDE1, for which immunohistochemical staining was performed. sITAC and CRC differ in genomic expression. CSDE1, previously found upregulated in CRC, was significantly differentially expressed. Using immunohistochemical staining, no sITACs displayed strong and diffuse staining for CSDE1, which represents a potential marker to use in distinguishing sITAC from a metastasis of colorectal origin. This knowledge could improve the diagnostic process and hopefully the outcome in patients with this rare tumor.
(© 2022 APMIS. Published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: Sinonasal; cancer; carcinoma; genomics; intestinal-type adenocarcinoma
المشرفين على المادة: 0 (Biomarkers, Tumor)
تواريخ الأحداث: Date Created: 20220606 Date Completed: 20220805 Latest Revision: 20220805
رمز التحديث: 20240628
DOI: 10.1111/apm.13252
PMID: 35662259
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0463
DOI:10.1111/apm.13252