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أعرض في EDS

What is the influence of grape products on liver enzymes? A systematic review and meta-analysis of randomized controlled trials.

التفاصيل البيبلوغرافية
العنوان: What is the influence of grape products on liver enzymes? A systematic review and meta-analysis of randomized controlled trials.
المؤلفون: Ghaffar S; Basic Health Unit, Hersa Sheikh, Chiniot, University Medical and Dental College, Faisalabad, Pakistan., Naqvi MA; Dental Section, Punjab Medical College, Faisalabad, Pakistan., Fayyaz A; Fatima Jinnah Medical University, Lahore, Pakistan., Abid MK; Department of Anesthesia, College of Health & Medical Technology, Al-Ayen University, Thi-Qar, Iraq., Khayitov KN; Tashkent Pediatric Medical Institute, Bogishamol Street 223, Tashkent, Uzbekistan., Jalil AT; Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla 51001, Iraq., Alsaikhan F; Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Kingdom of Saudi Arabia., Hammid AT; Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq., Al-Gazally ME; College of Medicine, University of Al-Ameed, Karbala, Iraq., Mohammadparast V; School of Health Sciences, Massey University, Wellington, New Zealand., Jannat B; Halal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran., Nouri M; Department of Community Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: mehran_nouri71@yahoo.com.
المصدر: Complementary therapies in medicine [Complement Ther Med] 2022 Oct; Vol. 69, pp. 102845. Date of Electronic Publication: 2022 Jun 06.
نوع المنشور: Journal Article; Meta-Analysis; Review; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Scotland NLM ID: 9308777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6963 (Electronic) Linking ISSN: 09652299 NLM ISO Abbreviation: Complement Ther Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Edinburgh : Elsevier
Original Publication: Edinburgh ; New York : Churchill Livingstone, c1993-
مواضيع طبية MeSH: Vitis*, Adult ; Alanine Transaminase ; Aspartate Aminotransferases ; Dietary Supplements ; Humans ; Liver ; Randomized Controlled Trials as Topic
مستخلص: Objective: This systematic review and meta-analysis were aimed to determine the effects of grape products on liver enzymes in adults.
Methods: Databases including PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus were searched up to February 2021. Randomized clinical trials (RCTs) investigating the effect of grape products on serum concentrations of liver enzymes were included. Data were pooled using the random-effects model and weighted mean difference (WMD) was considered as the summary effect size.
Results: Eight RCTs enrolling 291 participants met the inclusion criteria for this meta-analysis. The overall effect illustrated no significant change in serum levels of alanine aminotransferase (ALT) (WMD: - 2.04; 95 % CI: - 5.50 to 1.42; P = 0.24; I 2 = 72.5 %), and aspartate aminotransferase (AST) (WMD: - 1.40; 95 % CI: - 3.80 to 0.99; P = 0.25; I 2 = 76.0 %) in intervention group compared with the control group. Subgroup analyses revealed that the effect of grape products on ALT (WMD: - 4.97; 95 % CI: - 8.73 to - 1.21; P = 0.01) and AST (WMD: - 2.89; 95 % CI: - 5.69 to - 0.08; P = 0.04) levels was significant when the intervention period was equal or more than 12 weeks.
Conclusion: Overall, grape products had no significant effect on liver enzymes in adults. However, due to the low number of included studies, these findings must be interpreted with great caution. Larger, well-designed RCTs are still needed to further evaluate the capacity of the grape products as a complementary treatment to improve liver enzymes.
(Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Alanine aminotransferase; Aspartate aminotransferase; Grape; Liver function; Meta-analysis
المشرفين على المادة: EC 2.6.1.1 (Aspartate Aminotransferases)
EC 2.6.1.2 (Alanine Transaminase)
تواريخ الأحداث: Date Created: 20220607 Date Completed: 20220719 Latest Revision: 20220719
رمز التحديث: 20240628
DOI: 10.1016/j.ctim.2022.102845
PMID: 35671889
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6963
DOI:10.1016/j.ctim.2022.102845