دورية أكاديمية
Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats.
العنوان: | Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats. |
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المؤلفون: | Ratnaningtyas NI; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Hernayanti H; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Ekowati N; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Husen F; Department of Medical Laboratory of Technology, Bina Cipta Husada College of Health Science, Central Java, Indonesia. |
المصدر: | Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 1126-1136. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: [London] : Taylor & Francis Original Publication: Lisse, the Netherlands : Swets & Zeitlinger, c1998- |
مواضيع طبية MeSH: | Antioxidants*/chemistry , Coprinus*/chemistry , Diabetes Mellitus, Experimental*/chemically induced , Diabetes Mellitus, Experimental*/drug therapy , Hypoglycemic Agents*/chemistry, Animals ; Blood Glucose ; Ethanol ; Glucagon-Like Peptide 1 ; Glycated Hemoglobin/analysis ; Insulin ; Rats ; Rats, Wistar ; Streptozocin |
مستخلص: | Context: Edible mushrooms have a long history of use in traditional Chinese or Japanese medicine. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) contains antioxidant and antidiabetic agents. Objective: To identify the benefits of ethanol extracts of the C. comatus fruit body in streptozotocin-induced hyperglycaemic rats by evaluating their blood glucose, glycosylated haemoglobin (HbA1c), insulin, glucagon-like peptide-1 (GLP-1), dipeptidyl peptidase-4 (DPP-4), and glutathione (GSH) levels, with and without extract administration. Materials and Methods: Wistar rats were either left untreated or were administered 45 mg/kg body weight (BW) streptozotocin; 45 mg/kg BW metformin; or 250, 500, or 750 mg/kg BW extract for 14 days. The blood glucose, GLP-1, DPP-4, GSH, insulin, and HbA1c levels were determined. Data were analysed using analysis of variance and Duncan's multiple range tests. Results: Preliminary data showed that administration of C. comatus ethanol extract dose of 250, 500, and 750 mg orally has no toxicity effects after 24 h administration. The ethanolic extract of fruiting body of C. comatus considerably reduced the rat's fasting blood glucose levels 26.69%, and DPP-4 6.97% at dose of 750 mg. The extract reduced HbA1c 4-4.30%, increased GLP-1 71.09%, GSH 11.19% at dose of 500 mg, and increased insulin levels 13.83%. Extracts contain bioactive compounds such as flavonoid, alkaloid, terpenoids, vitamins C and E, rutin, and saponin. Conclusions: The C. comatus extract can be used as herbal medicine that reduces diabetic symptoms. Further investigation on C. comatus extracts should be conducted with gas chromatography-mass spectrometry to characterise the bioactive compounds. |
References: | CPT Pharmacometrics Syst Pharmacol. 2016 Jan;5(1):11-9. (PMID: 26844011) Diabetes Care. 2019 Apr;42(4):520-528. (PMID: 30765429) Life Sci. 2005 May 13;76(26):3069-80. (PMID: 15850599) Diabetes Care. 2017 Jan;40(Suppl 1):S64-S74. (PMID: 27979895) Gen Physiol Biophys. 1999 Oct;18 Spec No:54-62. (PMID: 10703720) Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1407-14. (PMID: 20448207) Phytother Res. 2010 Oct;24(10):1532-7. (PMID: 20878706) Behav Brain Res. 2001 Aug 1;122(2):201-7. (PMID: 11334650) Physiol Behav. 2014 Jun 22;133:8-13. (PMID: 24813700) Front Pharmacol. 2018 Jul 27;9:782. (PMID: 30100874) Front Pharmacol. 2017 Feb 23;8:74. (PMID: 28280467) Nutr Hosp. 2012 Jul-Aug;27(4):1261-6. (PMID: 23165571) J Food Sci Technol. 2017 Feb;54(2):430-438. (PMID: 28242942) J Ethnopharmacol. 2015 May 26;166:313-22. (PMID: 25749145) Biol Reprod. 2000 Feb;62(2):248-52. (PMID: 10642559) J Nutr Biochem. 2006 Aug;17(8):531-40. (PMID: 16443355) Endocr Rev. 2008 May;29(3):334-50. (PMID: 18048762) Physiol Res. 2001;50(6):537-46. (PMID: 11829314) Arch Biochem Biophys. 1993 Feb 1;300(2):535-43. (PMID: 8434935) Molecules. 2010 Mar 09;15(3):1473-86. (PMID: 20335995) Diabetes Care. 2007 Jun;30(6):1335-43. (PMID: 17337495) Biol Pharm Bull. 2001 Aug;24(8):876-82. (PMID: 11510477) Expert Rev Mol Med. 2014 Mar 26;16:e7. (PMID: 24666581) Physiol Res. 2005;54(1):49-56. (PMID: 15717841) Am J Med. 2005 Apr;118(4):422-5. (PMID: 15808142) Free Radic Biol Med. 2014 Jan;66:3-12. (PMID: 23557727) Appl Nurs Res. 2017 Feb;33:142-148. (PMID: 28096008) Asian Pac J Trop Biomed. 2012 Apr;2(4):281-6. (PMID: 23569914) Eur J Pharm Sci. 2012 Sep 29;47(2):512-9. (PMID: 22820565) J Sci Food Agric. 2021 Mar 15;101(4):1598-1608. (PMID: 32875596) Int J Med Mushrooms. 2021;23(10):9-21. (PMID: 34595888) |
فهرسة مساهمة: | Keywords: Bioactive compounds; DPP-4; GLP-1; diabetes mellitus; reactive oxygen species |
المشرفين على المادة: | 0 (Antioxidants) 0 (Blood Glucose) 0 (Glycated Hemoglobin A) 0 (Hypoglycemic Agents) 0 (Insulin) 3K9958V90M (Ethanol) 5W494URQ81 (Streptozocin) 89750-14-1 (Glucagon-Like Peptide 1) |
SCR Organism: | Coprinus comatus |
تواريخ الأحداث: | Date Created: 20220608 Date Completed: 20220610 Latest Revision: 20230111 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC9186368 |
DOI: | 10.1080/13880209.2022.2074054 |
PMID: | 35675226 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1744-5116 |
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DOI: | 10.1080/13880209.2022.2074054 |