دورية أكاديمية
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Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats.

التفاصيل البيبلوغرافية
العنوان: Ethanol extract of the mushroom Coprinus comatus exhibits antidiabetic and antioxidant activities in streptozotocin-induced diabetic rats.
المؤلفون: Ratnaningtyas NI; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Hernayanti H; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Ekowati N; Department of Biology, Faculty of Biology, Jenderal Soedirman University, Central Java, Indonesia., Husen F; Department of Medical Laboratory of Technology, Bina Cipta Husada College of Health Science, Central Java, Indonesia.
المصدر: Pharmaceutical biology [Pharm Biol] 2022 Dec; Vol. 60 (1), pp. 1126-1136.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 9812552 Publication Model: Print Cited Medium: Internet ISSN: 1744-5116 (Electronic) Linking ISSN: 13880209 NLM ISO Abbreviation: Pharm Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: [London] : Taylor & Francis
Original Publication: Lisse, the Netherlands : Swets & Zeitlinger, c1998-
مواضيع طبية MeSH: Antioxidants*/chemistry , Coprinus*/chemistry , Diabetes Mellitus, Experimental*/chemically induced , Diabetes Mellitus, Experimental*/drug therapy , Hypoglycemic Agents*/chemistry, Animals ; Blood Glucose ; Ethanol ; Glucagon-Like Peptide 1 ; Glycated Hemoglobin/analysis ; Insulin ; Rats ; Rats, Wistar ; Streptozocin
مستخلص: Context: Edible mushrooms have a long history of use in traditional Chinese or Japanese medicine. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) contains antioxidant and antidiabetic agents.
Objective: To identify the benefits of ethanol extracts of the C. comatus fruit body in streptozotocin-induced hyperglycaemic rats by evaluating their blood glucose, glycosylated haemoglobin (HbA1c), insulin, glucagon-like peptide-1 (GLP-1), dipeptidyl peptidase-4 (DPP-4), and glutathione (GSH) levels, with and without extract administration.
Materials and Methods: Wistar rats were either left untreated or were administered 45 mg/kg body weight (BW) streptozotocin; 45 mg/kg BW metformin; or 250, 500, or 750 mg/kg BW extract for 14 days. The blood glucose, GLP-1, DPP-4, GSH, insulin, and HbA1c levels were determined. Data were analysed using analysis of variance and Duncan's multiple range tests.
Results: Preliminary data showed that administration of C. comatus ethanol extract dose of 250, 500, and 750 mg orally has no toxicity effects after 24 h administration. The ethanolic extract of fruiting body of C. comatus considerably reduced the rat's fasting blood glucose levels 26.69%, and DPP-4 6.97% at dose of 750 mg. The extract reduced HbA1c 4-4.30%, increased GLP-1 71.09%, GSH 11.19% at dose of 500 mg, and increased insulin levels 13.83%. Extracts contain bioactive compounds such as flavonoid, alkaloid, terpenoids, vitamins C and E, rutin, and saponin.
Conclusions: The C. comatus extract can be used as herbal medicine that reduces diabetic symptoms. Further investigation on C. comatus extracts should be conducted with gas chromatography-mass spectrometry to characterise the bioactive compounds.
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فهرسة مساهمة: Keywords: Bioactive compounds; DPP-4; GLP-1; diabetes mellitus; reactive oxygen species
المشرفين على المادة: 0 (Antioxidants)
0 (Blood Glucose)
0 (Glycated Hemoglobin A)
0 (Hypoglycemic Agents)
0 (Insulin)
3K9958V90M (Ethanol)
5W494URQ81 (Streptozocin)
89750-14-1 (Glucagon-Like Peptide 1)
SCR Organism: Coprinus comatus
تواريخ الأحداث: Date Created: 20220608 Date Completed: 20220610 Latest Revision: 20230111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9186368
DOI: 10.1080/13880209.2022.2074054
PMID: 35675226
قاعدة البيانات: MEDLINE
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