دورية أكاديمية
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Phytochemicals as new therapeutic candidates simultaneously stimulate proliferation and counteract senescence of stem cells.

التفاصيل البيبلوغرافية
العنوان: Phytochemicals as new therapeutic candidates simultaneously stimulate proliferation and counteract senescence of stem cells.
المؤلفون: Yuan TJ; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China., Xu XH; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China., Zhou N; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China., Yan G; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China., Gu TW; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China., Peng LH; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau. Electronic address: lhpeng@zju.edu.cn.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Jul; Vol. 151, pp. 113170. Date of Electronic Publication: 2022 May 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: Cellular Senescence* , Mesenchymal Stem Cells*/metabolism, Cell Proliferation ; Cells, Cultured ; Phytochemicals/metabolism ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Stem Cells
مستخلص: Mesenchymal stem cells (MSCs) are promising candidates for regenerative therapy. However, the research and clinical application of MSCs are greatly hindered by the limited cells proliferation and replicative senescence. Therapeutic agents that can both enhance the proliferative ability and decrease the replicative senescence of MSCs are greatly needed, however, not been reported yet. Herein, for the first time, we identified 11 natural compounds from medicinal plants with both excellent proliferative and anti-senescence abilities in MSCs. The qPCR analysis indicated underlying mechanisms associated with fibroblast growth factor, transforming growth factor, Wnt/β-catenin and leukemia-induced factor in proliferation; the reactive oxygen species production, mitochondrial dysfunction autophagy and proteostasis are involved in cells senescence-related mechanism. Phytochemicals are demonstrated as novel therapeutic candidates with promising effects in both stimulating proliferation and retarding replicative senescence of stem cells with high safety.
(Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
فهرسة مساهمة: Keywords: Molecular mechanism; Phytochemicals; Proliferation; Senescence; Stem cells
المشرفين على المادة: 0 (Phytochemicals)
تواريخ الأحداث: Date Created: 20220609 Date Completed: 20220610 Latest Revision: 20220610
رمز التحديث: 20221213
DOI: 10.1016/j.biopha.2022.113170
PMID: 35676782
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2022.113170