دورية أكاديمية
أعرض في EDS

Brain regions associated with olfactory dysfunction in first episode psychosis patients.

التفاصيل البيبلوغرافية
العنوان: Brain regions associated with olfactory dysfunction in first episode psychosis patients.
المؤلفون: Etyemez S; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Narita Z; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mihaljevic M; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Coughlin JM; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nestadt G; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Nucifora FCJ; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sedlak TW; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Cascella NG; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Batt FD; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Hua J; Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA., Faria A; Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ishizuka K; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kamath V; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yang K; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Sawa A; Departments of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Departments of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
المصدر: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry [World J Biol Psychiatry] 2023 Feb; Vol. 24 (2), pp. 178-186. Date of Electronic Publication: 2022 Jun 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101120023 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1814-1412 (Electronic) Linking ISSN: 15622975 NLM ISO Abbreviation: World J Biol Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: Glasgow : WFSBP, 2000-
مواضيع طبية MeSH: Schizophrenia* , Psychotic Disorders*/complications , Olfaction Disorders*/complications, Humans ; Magnetic Resonance Imaging ; Brain/pathology
مستخلص: Objectives: Olfactory dysfunction is reproducibly reported in psychotic disorders, particularly in association with negative symptoms. The superior frontal gyrus (SFG) has been frequently studied in patients with psychotic disorders, in particular with their associations with negative symptoms. The relationship between olfactory functions and brain structure has been studied in healthy controls (HCs). Nevertheless, the studies with patients with psychotic disorders are limited. Here we report the olfactory-brain relationship in a first episode psychosis (FEP) cohort through both hypothesis-driven (centred on the SFG) and data-driven approaches.
Methods: Using data from 88 HCs and 76 FEP patients, we evaluated the correlation between olfactory functions and structural/resting-state functional magnetic resonance imaging (MRI) data.
Results: We found a significant correlation between the left SFG volume and odour discrimination in FEP patients, but not in HCs. We also observed a significant correlation between rs-fMRI connectivity involving the left SFG and odour discrimination in FEP patients, but not in HCs. The data-driven approach didn't observe any significant correlations, possibly due to insufficient statistical power.
Conclusion: The left SFG may be a promising brain region in the context of olfactory dysfunction and negative symptoms in FEP.
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معلومات مُعتمدة: P50 MH094268 United States MH NIMH NIH HHS; R01 MH092443 United States MH NIMH NIH HHS; R01 MH105660 United States MH NIMH NIH HHS; R01 MH107730 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Olfactory dysfunction; first episode psychosis; magnet resonance imaging; schizophrenia; superior frontal gyrus
تواريخ الأحداث: Date Created: 20220609 Date Completed: 20230224 Latest Revision: 20240202
رمز التحديث: 20240202
مُعرف محوري في PubMed: PMC10503825
DOI: 10.1080/15622975.2022.2082526
PMID: 35678361
قاعدة البيانات: MEDLINE
الوصف
تدمد:1814-1412
DOI:10.1080/15622975.2022.2082526