دورية أكاديمية
Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration.
| العنوان: | Acinetobacter quorum sensing contributes to inflammation-induced inhibition of orthopaedic implant osseointegration. |
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| المؤلفون: | Choe H, Hausman BS, Hujer KM, Akkus O, Rather PN, Lee Z, Bonomo RA, Greenfield EM; Department of Orthopaedic Surgery, Indiana University School of Medicine, Medical Sciences Building, Room 371, 635 Barnhill Drive, Indianapolis, IN, 46202, USA.egreenf@iu.edu. |
| المصدر: | European cells & materials [Eur Cell Mater] 2022 Jun 09; Vol. 43, pp. 267-276. Date of Electronic Publication: 2022 Jun 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Forum Multimedia Publishing LLC Country of Publication: Switzerland NLM ID: 100973416 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-2262 (Electronic) Linking ISSN: 14732262 NLM ISO Abbreviation: Eur Cell Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Charlottesville, VA : Forum Multimedia Publishing LLC Original Publication: [Glasgow] Scotland : European Cells & Materials, [2001]- |
| مواضيع طبية MeSH: | Acinetobacter*/physiology , Acinetobacter Infections*/microbiology , Orthopedics*, Animals ; Bacterial Proteins/pharmacology ; Humans ; Inflammation ; Mice ; Osseointegration ; Quorum Sensing |
| مستخلص: | Implant infection impairs osseointegration of orthopaedic implants by inducing inflammation. Acinetobacter spp. are increasingly prevalent multi-drug resistant bacteria that can cause osteomyelitis. Acinetobacter spp. can also cause inflammation and thereby inhibit osseointegration in mice. The purpose of the present study was to investigate the role of quorum sensing in this context. Therefore, wild-type bacteria were compared with an isogenic abaI mutant defective in quorum sensing in a murine osseointegration model. The abaI quorum- sensing mutant affected significantly less osseointegration and interleukin (IL) 1β levels, without detectably altering other pro-inflammatory cytokines. Wild-type bacteria had fewer effects on IL1 receptor (IL1R)-/- mice. These results indicated that quorum sensing in Acinetobacter spp. contributed to IL1β induction and the resultant inhibition of osseointegration in mice. Moreover, targeting the Gram-negative acyl-homoserine lactone quorum sensing may be particularly effective for patients with Acinetobacter spp. infections. |
| المشرفين على المادة: | 0 (Bacterial Proteins) |
| تواريخ الأحداث: | Date Created: 20220609 Date Completed: 20220613 Latest Revision: 20221004 |
| رمز التحديث: | 20231215 |
| DOI: | 10.22203/eCM.v043a18 |
| PMID: | 35678763 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-2262 |
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| DOI: | 10.22203/eCM.v043a18 |