دورية أكاديمية
أعرض في EDS

Lysosome lipid signalling from the periphery to neurons regulates longevity.

التفاصيل البيبلوغرافية
العنوان: Lysosome lipid signalling from the periphery to neurons regulates longevity.
المؤلفون: Savini M; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA., Folick A; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.; Medical Scientist Training Program, Baylor College of Medicine, Houston, TX, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Lee YT; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Integrative Program of Molecular and Biochemical Sciences, Baylor College of Medicine, Houston, TX, USA., Jin F; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA., Cuevas A; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Tillman MC; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Duffy JD; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA., Zhao Q; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Neve IA; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Hu PW; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Yu Y; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China., Zhang Q; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Ye Y; Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, USA., Mair WB; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wang J; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, TX, USA., Han L; Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX, USA.; Center of Epigenetics and Disease Prevention, Institute of Bioscience and Technology, Texas A&M University, Houston, TX, USA., Ortlund EA; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Wang MC; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA. wmeng@bcm.edu.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. wmeng@bcm.edu.; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX, USA. wmeng@bcm.edu.
المصدر: Nature cell biology [Nat Cell Biol] 2022 Jun; Vol. 24 (6), pp. 906-916. Date of Electronic Publication: 2022 Jun 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Macmillan Magazines Ltd., [1999-
مواضيع طبية MeSH: Caenorhabditis elegans Proteins*/genetics , Caenorhabditis elegans Proteins*/metabolism , Neuropeptides*/metabolism, 8,11,14-Eicosatrienoic Acid/metabolism ; Animals ; Caenorhabditis elegans/metabolism ; Longevity/genetics ; Lysosomes/metabolism ; Neurons/metabolism
مستخلص: Lysosomes are key cellular organelles that metabolize extra- and intracellular substrates. Alterations in lysosomal metabolism are implicated in ageing-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to regulate ageing remains unclear. Here we report a fat-to-neuron lipid signalling pathway induced by lysosomal metabolism and its longevity-promoting role in Caenorhabditis elegans. We discovered that induced lysosomal lipolysis in peripheral fat storage tissue upregulates the neuropeptide signalling pathway in the nervous system to promote longevity. This cell-non-autonomous regulation is mediated by a specific polyunsaturated fatty acid, dihomo-γ-linolenic acid, and LBP-3 lipid chaperone protein transported from the fat storage tissue to neurons. LBP-3 binds to dihomo-γ-linolenic acid, and acts through NHR-49 nuclear receptor and NLP-11 neuropeptide in neurons to extend lifespan. These results reveal lysosomes as a signalling hub to coordinate metabolism and ageing, and lysosomal signalling mediated inter-tissue communication in promoting longevity.
(© 2022. The Author(s).)
التعليقات: Comment in: Nat Cell Biol. 2022 Jun;24(6):808-810. (PMID: 35681007)
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معلومات مُعتمدة: R01 HG011633 United States HG NHGRI NIH HHS; P01 AG066606 United States AG NIA NIH HHS; P40 OD010440 United States OD NIH HHS; RF1 AG062257 United States AG NIA NIH HHS; R01 AG044346 United States AG NIA NIH HHS; R01 AG045183 United States AG NIA NIH HHS; T32 GM008602 United States GM NIGMS NIH HHS; R01 CA262623 United States CA NCI NIH HHS; United States HHMI Howard Hughes Medical Institute; RF1 AG074540 United States AG NIA NIH HHS; T32 ES027801 United States ES NIEHS NIH HHS; DP1 DK113644 United States DK NIDDK NIH HHS; R01 AT009050 United States AT NCCIH NIH HHS; R03 AG070417 United States AG NIA NIH HHS
المشرفين على المادة: 0 (Caenorhabditis elegans Proteins)
0 (Neuropeptides)
FC398RK06S (8,11,14-Eicosatrienoic Acid)
تواريخ الأحداث: Date Created: 20220610 Date Completed: 20220620 Latest Revision: 20230419
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9203275
DOI: 10.1038/s41556-022-00926-8
PMID: 35681008
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-4679
DOI:10.1038/s41556-022-00926-8