دورية أكاديمية
Quantification of Low Amounts of Zoledronic Acid by HPLC-ESI-MS Analysis: Method Development and Validation.
| العنوان: | Quantification of Low Amounts of Zoledronic Acid by HPLC-ESI-MS Analysis: Method Development and Validation. |
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| المؤلفون: | Petrovici AR; Centre of Advanced Research in Bionanoconjugates and Biopolymers, 'Petru Poni' Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania., Silion M; Physics of Polymers and Polymeric Materials Department, 'Petru Poni' Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania., Simionescu N; Centre of Advanced Research in Bionanoconjugates and Biopolymers, 'Petru Poni' Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania., Kallala R; Corthotec Limited, 130 Wood Street, London EC2V 6DL, UK., Pinteala M; Centre of Advanced Research in Bionanoconjugates and Biopolymers, 'Petru Poni' Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania., Maier SS; Centre of Advanced Research in Bionanoconjugates and Biopolymers, 'Petru Poni' Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania.; Polymers Research Center, 'Gheorghe Asachi' Technical University of Iasi, 73 Dimitrie Mangeron Blvd., 700050 Iasi, Romania. |
| المصدر: | International journal of molecular sciences [Int J Mol Sci] 2022 May 25; Vol. 23 (11). Date of Electronic Publication: 2022 May 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
| مواضيع طبية MeSH: | Calcium* , Spectrometry, Mass, Electrospray Ionization*/methods, Chromatography, High Pressure Liquid/methods ; Zoledronic Acid |
| مستخلص: | Zoledronic acid (ZA) is used in the treatment of various bone pathologies, but it forms complexes with calcium ions present in body fluids, decreasing ZA bioavailability. Thereby, the study first describes the identification of ZA-calcium complexes that form in calcium-rich environments, in order to establish the bioavailable ZA concentration. Then, a new method for quantification of low ZA amounts in milieus that mimics in vivo conditions by using simulated body fluid and calcium sulfate hemihydrate was described. Almost all analytical methods of ZA quantification described in the literature require compound derivatization. At very low concentrations, derivatization is prone to analyte loss, therefore compromising the analytical results. In our study, we avoided ZA derivatization by using a high-performance liquid chromatography and electrospray ionization mass spectrometry (HPLC-ESI-MS) system, conducting the investigation based on the fragmentation mass extracted ion chromatograms specific to the ZA protonated form. The method was validated by selectivity, precision, accuracy, linearity, signal to noise ratio, and limit of detection and limit of quantification calculation. Experimentally, this method can detect ranges of 0.1-0.5 ng/mL and precisely quantify ZA concentrations as low as 0.1 ng/mL. This method could provide the basis for quantifying low amounts of ZA in the blood during long-term administration. |
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| معلومات مُعتمدة: | PN-III-P4-ID-PCCF-2016-0050 Ministerul Cercetării și Inovării; Project "Infra SupraChem Lab - Center for Advanced Research in Supramolecular Chemistry" (Contract 339/390015/25.02.2021, cod MySMIS: 108983) European Social Fund for Regional Development, Competitiveness Operational Programme Axis 1, Action: 1.1.3 |
| فهرسة مساهمة: | Keywords: HPLC-ESI-MS analysis; ZA-calcium complexes; calcium sulfate hemihydrate; extracted ion chromatogram (EIC); method development and validation; solid inorganic matrix; zoledronic acid (ZA) |
| المشرفين على المادة: | 6XC1PAD3KF (Zoledronic Acid) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20220610 Date Completed: 20220613 Latest Revision: 20220716 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9180824 |
| DOI: | 10.3390/ijms23115944 |
| PMID: | 35682618 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1422-0067 |
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| DOI: | 10.3390/ijms23115944 |