دورية أكاديمية
Divergent white matter changes in patients with nasopharyngeal carcinoma post-radiotherapy with different outcomes: a potential biomarker for prediction of radiation necrosis.
| العنوان: | Divergent white matter changes in patients with nasopharyngeal carcinoma post-radiotherapy with different outcomes: a potential biomarker for prediction of radiation necrosis. |
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| المؤلفون: | Lin X; Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518052, China., Li Z; Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, China., Chen S; Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518052, China., Yang Y; Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, China., He H; Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, China., Lv X; Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, 510060, China. lvxf@sysucc.org.cn., Qiu Y; Department of Radiology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518052, China. qiuyw1201@gmail.com. |
| المصدر: | European radiology [Eur Radiol] 2022 Oct; Vol. 32 (10), pp. 7036-7047. Date of Electronic Publication: 2022 Jun 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 9114774 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1084 (Electronic) Linking ISSN: 09387994 NLM ISO Abbreviation: Eur Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1991- |
| مواضيع طبية MeSH: | Nasopharyngeal Neoplasms*/pathology , Nasopharyngeal Neoplasms*/radiotherapy , Radiation Injuries*/etiology , White Matter*/diagnostic imaging , White Matter*/pathology, Atrophy/pathology ; Biomarkers ; Humans ; Nasopharyngeal Carcinoma/pathology ; Nasopharyngeal Carcinoma/radiotherapy ; Necrosis/pathology |
| مستخلص: | Objectives: To investigate the effects of standard radiotherapy on temporal white matter (WM) and its relationship with radiation necrosis (RN) in patients with nasopharyngeal carcinoma (NPC), and to determine the predictive value of WM volume alterations at the early stage for RN occurrence at the late-delay stage. Methods: Seventy-four treatment-naive NPC patients treated with standard radiotherapy were longitudinally followed up for 36 months. Structural MRIs were collected at multiple time points during the first year post-radiotherapy. Longitudinal structural images were processed using FreeSurfer. Linear mixed models were used to delineate divergent trajectories of temporal WM changes between patients who developed RN and who did not. Four machine learning methods were used to construct predictive models for RN with temporal WM volume alterations at early-stage. Results: The superior temporal gyrus (STG) had divergent atrophy trajectories in NPC patients with different outcomes (RN vs. NRN) post-radiotherapy. Patients with RN showed more rapid atrophy than those with NRN. A predictive model constructed with temporal WM volume alterations at early-stage post-radiotherapy had good performance for RN; the areas under the curve (AUC) were 0.879 and 0.806 at 1-3 months and 6 months post-radiotherapy, respectively. Moreover, the predictive model constructed with absolute temporal volume at 1-3 months post-radiotherapy also presented good performance; the AUC was 0.842, which was verified by another independent dataset (AUC = 0.773). Conclusions: NPC patients with RN had more sharp atrophy in the STG than those with NRN. Temporal WM volume at early-stage post-radiotherapy may serve as an in vivo biomarker to identify and predict RN occurrence. Key Points: • The STG had divergent atrophy trajectories in NPC patients with different outcomes (RN vs. NRN) post-radiotherapy. • Although both groups exhibited time-dependent atrophy in the STG, the patients with RN showed a more rapid volume decrease than those with NRN. • Temporal WM volume alteration (or absolute volume) at the early stage could predict RN occurrence at the late-delay stage after radiotherapy. (© 2022. The Author(s), under exclusive licence to European Society of Radiology.) |
| التعليقات: | Erratum in: Eur Radiol. 2022 Aug 19;:. (PMID: 35984516) |
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| معلومات مُعتمدة: | 81401399 Natural Science Foundation of China (CN); 81560283 Natural Science Foundation of China (CN); 81201084 Natural Science Foundation of China (CN); 2019A1515011143 Natural Science Foundation of Guangdong (CN); 2020A1515011332 Natural Science Foundation of Guangdong (CN); 2022A1515012503 Natural Science Foundation of Guangdong (CN) |
| فهرسة مساهمة: | Keywords: Machine learning; Nasopharyngeal carcinoma; Radiation-induced temporal lobe necrosis; Radiotherapy; White matter |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20220610 Date Completed: 20220916 Latest Revision: 20221215 |
| رمز التحديث: | 20221215 |
| DOI: | 10.1007/s00330-022-08907-z |
| PMID: | 35687134 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1007/s00330-022-08907-z |