دورية أكاديمية
أعرض في EDS

Do different lipid components accelerate the pathogenesis and severity of Diabetic Retinopathy?

التفاصيل البيبلوغرافية
العنوان: Do different lipid components accelerate the pathogenesis and severity of Diabetic Retinopathy?
المؤلفون: Mondal LK; Department of Ophthalmology, Regional Institute of Ophthalmology, Medical College Campus, Kolkata, 700 073, West Bengal, India. Lakshmi.mondal62@gmail.com., Pramanik S; Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, 700020, West Bengal, India., Chowdhury S; Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, 700020, West Bengal, India., Bose C; Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, 700020, West Bengal, India., Bera D; Department of Endocrinology & Metabolism, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, 700020, West Bengal, India., Saha A; Department of Rheumatology, Institute of Post Graduate Medical Education & Research and SSKM Hospital, Kolkata, 700020, West Bengal, India., Bhattacharjee K; Department of Ophthalmology, Regional Institute of Ophthalmology, Medical College Campus, Kolkata, 700 073, West Bengal, India.
المصدر: International journal of retina and vitreous [Int J Retina Vitreous] 2022 Jun 11; Vol. 8 (1), pp. 39. Date of Electronic Publication: 2022 Jun 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101677897 Publication Model: Electronic Cited Medium: Print ISSN: 2056-9920 (Print) Linking ISSN: 20569920 NLM ISO Abbreviation: Int J Retina Vitreous Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2015]-
مستخلص: Background: To assess the association of lipid and lipid-derived toxic molecules in pathogenesis and severity of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM).
Methods: The present cross-sectional study included 14 healthy individuals (HC) without T2DM, 22 T2DM subjects without DR (DNR), 24 T2DM subjects with mild non-proliferative DR (MNPDR), and 24 T2DM subjects with high-risk proliferative DR (HRPDR). All subjects underwent plasma and vitreous analysis for estimation of total lipid (TL), free fatty acid (FFA), lipid peroxides (LPOs) like malondialdehyde (MDA), 4-Hydroxy-noneal (HNE), the advanced lipoxidation end product (ALE) like Hexanoyl-lysine (HLY) and vascular endothelial growth factor (VEGF) following standard spectrophotometric and enzyme-linked immunosorbent assay (ELISA) methods respectively.
Results: The concentration of TL, FFA, markers of lipid peroxidation and lipoxidation as well as VEGF in plasma and vitreous were found to be significantly elevated stepwise inT2DM subjects (HRPDR > MNPDR > DNR) compared to healthy controls (HC).Further, plasma conventional lipid components like total cholesterol (TCH), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG), FFA and TL showed their significant positive correlations with vitreous level of different LPOs, ALE and VEGF in the DR group.
Conclusion: Total lipid and lipid-derived detrimental biomolecules ultimately result in increased secretion of VEGF and thus not only add as associated mediators in the pathogenesis of DR, these also accelerate the severity of microangiopathy in T2DM.
(© 2022. The Author(s).)
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فهرسة مساهمة: Keywords: Advanced lipoxidation end products; Diabetic retinopathy; Lipid peroxides; Type 2 diabetes mellitus; Vascular endothelial growth factor
تواريخ الأحداث: Date Created: 20220611 Latest Revision: 20220716
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9188217
DOI: 10.1186/s40942-022-00390-4
PMID: 35690853
قاعدة البيانات: MEDLINE
الوصف
تدمد:2056-9920
DOI:10.1186/s40942-022-00390-4