دورية أكاديمية
أعرض في EDS

Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease.

التفاصيل البيبلوغرافية
العنوان: Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease.
المؤلفون: Shin SY; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Kim Y; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Kim WS; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Moon JM; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Lee KM; Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea., Jung SA; Department of Internal Medicine, Graduate Program in System Health Science and Engineering, Ewha Womans University College of Medicine, Seoul, Korea., Park H; Department of Preventive Medicine, Graduate Program in System Health Science and Engineering, Ewha Womans University College of Medicine, Seoul, Korea., Huh EY; South Texas Center of Emerging Infectious Diseases (STCEID) and Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX, USA., Kim BC; Division of Gastroenterology, Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea., Lee SC; South Texas Center of Emerging Infectious Diseases (STCEID) and Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX, USA., Choi CH; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
مؤلفون مشاركون: IBD Research Group of the Korean Association for the Study of Intestinal Diseases; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
المصدر: Intestinal research [Intest Res] 2023 Jan; Vol. 21 (1), pp. 148-160. Date of Electronic Publication: 2022 Jun 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taehan Chang Yŏn'gu Hakhoe Country of Publication: Korea (South) NLM ID: 101572802 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1598-9100 (Print) Linking ISSN: 15989100 NLM ISO Abbreviation: Intest Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Sŏul : Taehan Chang Yŏn'gu Hakhoe
مستخلص: Background/aims: The fecal microbiota of Korean patients with inflammatory bowel disease (IBD) was investigated with respect to disease phenotypes and taxonomic biomarkers for diagnosis and prognosis of IBD.
Methods: Fecal samples from 70 ulcerative colitis (UC) patients, 39 Crohn's disease (CD) patients, and 100 healthy control individuals (HC) were collected. The fecal samples were amplified via polymerase chain reaction and sequenced using Illumina MiSeq. The relationships between fecal bacteria and clinical phenotypes were analyzed using the EzBioCloud database and 16S microbiome pipeline.
Results: The alpha-diversity of fecal bacteria was significantly lower in UC and CD (P<0.05) compared to that in HC. Bacterial community compositions in UC and CD were significantly different from that of HC according to Bray-Curtis dissimilarities, and there was also a difference between community composition in UC and CD (P=0.01). In UC, alpha-diversity was further decreased when the disease was more severe and the extent of disease was greater, and community composition significantly differed depending on the extent of the disease. We identified 9 biomarkers of severity and 6 biomarkers of the extent of UC. We also identified 5 biomarkers of active disease and 3 biomarkers of ileocolonic involvement in CD. Lachnospiraceae and Ruminococcus gnavus were biomarkers for better prognosis in CD.
Conclusions: The fecal microbiota profiles of IBD patients were different from those of HC, and several bacterial taxa may be used as biomarkers to determine disease phenotypes and prognosis. These data may also help discover new therapeutic targets for IBD.
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معلومات مُعتمدة: 2020R1F1A1075489 National Research Foundation of Korea; Korean Association for the Study of Intestinal Diseases; CTSA/IIMS UT Health Pilot Grant; Max and Minnie Tomerlin Voelcker Fund
فهرسة مساهمة: Keywords: Biomarkers; Inflammatory bowel disease; Microbiota; Phenotype; Prognosis
تواريخ الأحداث: Date Created: 20220613 Latest Revision: 20230217
رمز التحديث: 20230217
مُعرف محوري في PubMed: PMC9911276
DOI: 10.5217/ir.2021.00168
PMID: 35692191
قاعدة البيانات: MEDLINE
الوصف
تدمد:1598-9100
DOI:10.5217/ir.2021.00168