دورية أكاديمية
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease.
العنوان: | Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease. |
---|---|
المؤلفون: | Shin SY; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Kim Y; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Kim WS; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Moon JM; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea., Lee KM; Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea., Jung SA; Department of Internal Medicine, Graduate Program in System Health Science and Engineering, Ewha Womans University College of Medicine, Seoul, Korea., Park H; Department of Preventive Medicine, Graduate Program in System Health Science and Engineering, Ewha Womans University College of Medicine, Seoul, Korea., Huh EY; South Texas Center of Emerging Infectious Diseases (STCEID) and Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX, USA., Kim BC; Division of Gastroenterology, Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea., Lee SC; South Texas Center of Emerging Infectious Diseases (STCEID) and Department of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX, USA., Choi CH; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. |
مؤلفون مشاركون: | IBD Research Group of the Korean Association for the Study of Intestinal Diseases; Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. |
المصدر: | Intestinal research [Intest Res] 2023 Jan; Vol. 21 (1), pp. 148-160. Date of Electronic Publication: 2022 Jun 14. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Taehan Chang Yŏn'gu Hakhoe Country of Publication: Korea (South) NLM ID: 101572802 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1598-9100 (Print) Linking ISSN: 15989100 NLM ISO Abbreviation: Intest Res Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Sŏul : Taehan Chang Yŏn'gu Hakhoe |
مستخلص: | Background/aims: The fecal microbiota of Korean patients with inflammatory bowel disease (IBD) was investigated with respect to disease phenotypes and taxonomic biomarkers for diagnosis and prognosis of IBD. Methods: Fecal samples from 70 ulcerative colitis (UC) patients, 39 Crohn's disease (CD) patients, and 100 healthy control individuals (HC) were collected. The fecal samples were amplified via polymerase chain reaction and sequenced using Illumina MiSeq. The relationships between fecal bacteria and clinical phenotypes were analyzed using the EzBioCloud database and 16S microbiome pipeline. Results: The alpha-diversity of fecal bacteria was significantly lower in UC and CD (P<0.05) compared to that in HC. Bacterial community compositions in UC and CD were significantly different from that of HC according to Bray-Curtis dissimilarities, and there was also a difference between community composition in UC and CD (P=0.01). In UC, alpha-diversity was further decreased when the disease was more severe and the extent of disease was greater, and community composition significantly differed depending on the extent of the disease. We identified 9 biomarkers of severity and 6 biomarkers of the extent of UC. We also identified 5 biomarkers of active disease and 3 biomarkers of ileocolonic involvement in CD. Lachnospiraceae and Ruminococcus gnavus were biomarkers for better prognosis in CD. Conclusions: The fecal microbiota profiles of IBD patients were different from those of HC, and several bacterial taxa may be used as biomarkers to determine disease phenotypes and prognosis. These data may also help discover new therapeutic targets for IBD. |
References: | Clin Gastroenterol Hepatol. 2007 Mar;5(3):339-44. (PMID: 17368233) Lancet. 2017 Apr 29;389(10080):1756-1770. (PMID: 27914657) Gut Pathog. 2020 Jan 04;12:1. (PMID: 31911822) Sci Rep. 2019 Sep 17;9(1):13473. (PMID: 31530835) J Neurogastroenterol Motil. 2021 Jan 30;27(1):134-146. (PMID: 33380558) N Engl J Med. 2011 Nov 3;365(18):1713-25. (PMID: 22047562) Clin Gastroenterol Hepatol. 2009 Sep;7(9):981-7. (PMID: 19523534) Intest Res. 2019 Jul;17(3):285-310. (PMID: 31146509) Inflamm Bowel Dis. 2011 Jan;17(1):179-84. (PMID: 20839241) Eur J Radiol. 2006 Apr;58(1):140-6. (PMID: 16337356) J Clin Microbiol. 2014 Feb;52(2):398-406. (PMID: 24478468) Gastroenterology. 2017 Aug;153(2):430-438.e2. (PMID: 28479377) Gastroenterology. 2015 Oct;149(5):1275-1285.e2. (PMID: 26166315) Intest Res. 2020 Apr;18(2):151-167. (PMID: 32326669) Gut. 2003 Feb;52(2):237-42. (PMID: 12524406) Front Immunol. 2017 Nov 28;8:1674. (PMID: 29234327) Gastroenterology. 1976 Mar;70(3):439-44. (PMID: 1248701) Intest Res. 2020 Jul;18(3):337-340. (PMID: 32306706) Nature. 2013 Dec 19;504(7480):451-5. (PMID: 24226773) Cell Host Microbe. 2007 Aug 16;2(2):119-29. (PMID: 18005726) Nat Microbiol. 2019 Feb;4(2):293-305. (PMID: 30531976) BMC Gastroenterol. 2013 Apr 08;13:61. (PMID: 23566070) Dig Dis Sci. 2008 Sep;53(9):2495-506. (PMID: 18157694) Aliment Pharmacol Ther. 2001 Aug;15(8):1219-25. (PMID: 11472326) Gut. 2006 Feb;55(2):205-11. (PMID: 16188921) Scand J Gastroenterol. 2016 Dec;51(12):1407-1415. (PMID: 27687331) Sci Rep. 2019 Jan 24;9(1):601. (PMID: 30679604) Gastroenterology. 2009 Jan;136(1):65-80. (PMID: 19026645) Front Microbiol. 2018 Sep 25;9:2247. (PMID: 30319571) PLoS One. 2012;7(6):e39242. (PMID: 22768065) Gastroenterology. 2010 Dec;139(6):1844-1854.e1. (PMID: 20816835) Intest Res. 2022 Jul;20(3):370-380. (PMID: 33975420) Gut. 2011 May;60(5):631-7. (PMID: 21209126) Scand J Gastroenterol. 2015 Jan;50(1):34-42. (PMID: 25523554) World J Gastroenterol. 2005 Sep 7;11(33):5185-92. (PMID: 16127750) Nat Med. 2019 Feb;25(2):323-336. (PMID: 30664783) Gastroenterology. 2004 Aug;127(2):412-21. (PMID: 15300573) Microbiology (Reading). 2005 Jul;151(Pt 7):2323-2330. (PMID: 16000722) Front Physiol. 2018 Jun 25;9:775. (PMID: 29988585) Expert Rev Gastroenterol Hepatol. 2010 Oct;4(5):589-600. (PMID: 20932144) Am J Gastroenterol. 2009 Nov;104(11):2768-73. (PMID: 19672253) J Clin Microbiol. 2006 Nov;44(11):3980-8. (PMID: 16988018) N Engl J Med. 1987 Dec 24;317(26):1625-9. (PMID: 3317057) Nature. 2013 Dec 19;504(7480):446-50. (PMID: 24226770) Am J Gastroenterol. 2001 Mar;96(3):730-4. (PMID: 11280542) Am J Gastroenterol. 2015 Jun;110(6):921-30. (PMID: 25986361) Gastroenterology. 2020 Mar;158(4):930-946.e1. (PMID: 31812509) Cell Host Microbe. 2014 Mar 12;15(3):382-392. (PMID: 24629344) Inflamm Bowel Dis. 2005 May;11(5):481-7. (PMID: 15867588) J Crohns Colitis. 2009 Feb;3(1):4-7. (PMID: 21172241) Intest Res. 2021 Oct;19(4):360-364. (PMID: 33249800) Clin Exp Gastroenterol. 2019 Jan 31;12:37-49. (PMID: 30774408) Anaerobe. 2004 Jun;10(3):179-84. (PMID: 16701516) Medicine (Baltimore). 2018 Feb;97(5):e9772. (PMID: 29384868) Intest Res. 2020 Oct;18(4):347-354. (PMID: 33131231) Nat Immunol. 2019 Apr;20(4):471-481. (PMID: 30778241) |
معلومات مُعتمدة: | 2020R1F1A1075489 National Research Foundation of Korea; Korean Association for the Study of Intestinal Diseases; CTSA/IIMS UT Health Pilot Grant; Max and Minnie Tomerlin Voelcker Fund |
فهرسة مساهمة: | Keywords: Biomarkers; Inflammatory bowel disease; Microbiota; Phenotype; Prognosis |
تواريخ الأحداث: | Date Created: 20220613 Latest Revision: 20230217 |
رمز التحديث: | 20230217 |
مُعرف محوري في PubMed: | PMC9911276 |
DOI: | 10.5217/ir.2021.00168 |
PMID: | 35692191 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1598-9100 |
---|---|
DOI: | 10.5217/ir.2021.00168 |